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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1994 4
1995 10
1996 12
1997 30
1998 26
1999 37
2000 42
2001 48
2002 50
2003 59
2004 44
2005 45
2006 67
2007 51
2008 49
2009 40
2010 40
2011 45
2012 50
2013 42
2014 30
2015 54
2016 39
2017 44
2018 36
2019 34
2020 36
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982 results
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Page 1
Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson's disease.
Williams GP, Schonhoff AM, Jurkuvenaite A, Thome AD, Standaert DG, Harms AS. Williams GP, et al. J Neuroinflammation. 2018 Aug 30;15(1):244. doi: 10.1186/s12974-018-1286-2. J Neuroinflammation. 2018. PMID: 30165873 Free PMC article.
In vivo, an adeno-associated virus (AAV) was used to overexpress α-syn in WT and CIITA -/- mice as a model for PD. Concurrently with AAV-mediated overexpression of α-syn, WT mice received CIITA-targeted shRNAs packaged in lentiviral constructs. ...In vivo, global kn …
In vivo, an adeno-associated virus (AAV) was used to overexpress α-syn in WT and CIITA -/- mice as a model for PD. Concurrently with …
Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5.
Buxadé M, Huerga Encabo H, Riera-Borrull M, Quintana-Gallardo L, López-Cotarelo P, Tellechea M, Martínez-Martínez S, Redondo JM, Martín-Caballero J, Flores JM, Bosch E, Rodríguez-Fernández JL, Aramburu J, López-Rodríguez C. Buxadé M, et al. J Exp Med. 2018 Nov 5;215(11):2901-2918. doi: 10.1084/jem.20180314. Epub 2018 Oct 16. J Exp Med. 2018. PMID: 30327417 Free PMC article.
Expression of MHCII genes is controlled by the transcription coactivator CIITA, itself regulated through cell type-specific promoters. ...Ultrasequencing analysis of NFAT5-immunoprecipitated chromatin uncovered an NFAT5-regulated region distally upstream of Ciita Th …
Expression of MHCII genes is controlled by the transcription coactivator CIITA, itself regulated through cell type-specific promoters …
Restriction factors in human retrovirus infections and the unprecedented case of CIITA as link of intrinsic and adaptive immunity against HTLV-1.
Forlani G, Shallak M, Ramia E, Tedeschi A, Accolla RS. Forlani G, et al. Retrovirology. 2019 Nov 29;16(1):34. doi: 10.1186/s12977-019-0498-6. Retrovirology. 2019. PMID: 31783769 Free PMC article. Review.
We describe the multiple molecular mechanisms through which CIITA exerts its restriction on retroviruses. Of relevance, we review the unprecedented findings pointing to a concerted action of several restriction factors such as CIITA, TRIM22 and TRIM19/PML in synergi …
We describe the multiple molecular mechanisms through which CIITA exerts its restriction on retroviruses. Of relevance, we review the …
MHC2TA and FCRL3 genes are not associated with rheumatoid arthritis in Mexican patients.
Mendoza Rincón JF, Rodríguez Elias AK, Fragoso JM, Vargas Alarcón G, Maldonado Murillo K, Rivas Jiménez ML, Barbosa Cobos RE, Jimenez Morales S, Lugo Zamudio G, Tovilla Zárate C, Ramírez Bello J. Mendoza Rincón JF, et al. Rheumatol Int. 2016 Feb;36(2):249-54. doi: 10.1007/s00296-015-3358-2. Epub 2015 Sep 8. Rheumatol Int. 2016. PMID: 26350270
The MHC2TA and FCRL3 genes have been associated previously with RA in Swedish and Japanese populations, respectively. In two recent reports, we show an association between FCRL3 and juvenile rheumatoid arthritis (JRA), and MHC2TA and acute coronary syndrome (ACS) in …
The MHC2TA and FCRL3 genes have been associated previously with RA in Swedish and Japanese populations, respectively. In two recent r …
CIITA-Driven MHC Class II Expressing Tumor Cells as Antigen Presenting Cell Performers: Toward the Construction of an Optimal Anti-tumor Vaccine.
Accolla RS, Ramia E, Tedeschi A, Forlani G. Accolla RS, et al. Front Immunol. 2019 Jul 30;10:1806. doi: 10.3389/fimmu.2019.01806. eCollection 2019. Front Immunol. 2019. PMID: 31417570 Free PMC article. Review.
By genetically modifying tumor cells of distinct histological origin with the MHC-II transactivator CIITA, the physiological controller of MHC-II gene expression discovered in our laboratory, stable expression of all MHC class II genes was obtained. ...Additionally, our ap …
By genetically modifying tumor cells of distinct histological origin with the MHC-II transactivator CIITA, the physiological controll …
Immune Regulatory Genes Are Major Genetic Factors to Behcet Disease: Systematic Review.
Deng Y, Zhu W, Zhou X. Deng Y, et al. Open Rheumatol J. 2018 Jun 29;12:70-85. doi: 10.2174/1874312901812010070. eCollection 2018. Open Rheumatol J. 2018. PMID: 30069262 Free PMC article. Review.
The major genes with polymorphisms associated with BD include HLA-B and -A, CIITA, ERAP1, MICA, IL10, IL12A, IL12RB2, IL23R, MEFV, IRF8, TNFAIP3, REL, TLR4, NOD1,2, CCR1,CCR3, GIMAP1,2,4, KLRC4, STAT4, NCOA5, FOXP3, PSORS1C1, FUT2, UBAC2, SUMO4, ADO-EGR2, CEBPB-PTPN1, and …
The major genes with polymorphisms associated with BD include HLA-B and -A, CIITA, ERAP1, MICA, IL10, IL12A, IL12RB2, IL23R, MEFV, IR …
Multiple sclerosis: an example of pathogenic viral interaction?
Fierz W. Fierz W. Virol J. 2017 Feb 28;14(1):42. doi: 10.1186/s12985-017-0719-3. Virol J. 2017. PMID: 28241767 Free PMC article. Review.
Forkhead transcription factor FOXO3a mediates interferon-γ-induced MHC II transcription in macrophages.
Wu X, Fan Z, Chen M, Chen Y, Rong D, Cui Z, Yuan Y, Zhuo L, Xu Y. Wu X, et al. Immunology. 2019 Dec;158(4):304-313. doi: 10.1111/imm.13116. Epub 2019 Oct 3. Immunology. 2019. PMID: 31509237
Interferon-γ (IFN-γ) activates MHC II transcription via the assembly of an enhanceosome centred on class II trans-activator (CIITA). ...Of interest, FOXO3a was recruited to the type IV CIITA promoter and directly activated CIITA transcription by interacting w …
Interferon-γ (IFN-γ) activates MHC II transcription via the assembly of an enhanceosome centred on class II trans-activator (CIITA). …
Mycobacterium tuberculosis EsxL inhibits MHC-II expression by promoting hypermethylation in class-II transactivator loci in macrophages.
Sengupta S, Naz S, Das I, Ahad A, Padhi A, Naik SK, Ganguli G, Pattanaik KP, Raghav SK, Nandicoori VK, Sonawane A. Sengupta S, et al. J Biol Chem. 2017 Apr 28;292(17):6855-6868. doi: 10.1074/jbc.M117.775205. Epub 2017 Feb 16. J Biol Chem. 2017. PMID: 28209712 Free PMC article. Retracted.
One of the key mechanisms includes repression of class-II transactivator (CIITA) and MHC-II expression in infected macrophages. ...A chromatin immunoprecipitation assay confirmed that hypermethylation at the promoter IV region of CIITA is mainly responsible for C
One of the key mechanisms includes repression of class-II transactivator (CIITA) and MHC-II expression in infected macrophages. ...A …
Link between CIITA rs3087456 polymorphism and the risk of laryngeal squamous cell carcinoma in a Chinese population.
Xue Y, Tang D, Li SJ, Zhou J, Hsueh CY, Zhao DD, Heng Y, Tao L, Lu LM. Xue Y, et al. Pathol Res Pract. 2020 Jan;216(1):152793. doi: 10.1016/j.prp.2019.152793. Epub 2019 Dec 18. Pathol Res Pract. 2020. PMID: 31870593
The class II trans-activator (CIITA) is the master regulator of the major histocompatibility complex (MHC) gene expression. CIITA mutations have been previously associated with several kinds of tumors, while the role of CIITA polymorphisms (rs3087456) in lary …
The class II trans-activator (CIITA) is the master regulator of the major histocompatibility complex (MHC) gene expression. CIITA
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