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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 1
1975 1
1976 1
1977 3
1978 1
1979 4
1980 2
1981 2
1982 2
1983 1
1984 2
1985 6
1986 3
1987 2
1988 9
1989 2
1990 6
1991 6
1992 1
1993 10
1994 12
1995 20
1996 24
1997 18
1998 20
1999 23
2000 19
2001 20
2002 26
2003 30
2004 20
2005 27
2006 23
2007 29
2008 43
2009 43
2010 54
2011 55
2012 57
2013 75
2014 83
2015 85
2016 100
2017 98
2018 130
2019 130
2020 121
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1,320 results
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Page 1
The Hippo Pathway: Immunity and Cancer.
Taha Z, Janse van Rensburg HJ, Yang X. Taha Z, et al. Cancers (Basel). 2018 Mar 28;10(4):94. doi: 10.3390/cancers10040094. Cancers (Basel). 2018. PMID: 29597279 Free PMC article. Review.
Canonical signaling through the Hippo pathway core components (MST1/2, LATS1/2, YAP and TAZ) is important for development and tissue homeostasis while aberrant signaling through the Hippo pathway has been implicated in multiple pathologies, including cancer. ...
Canonical signaling through the Hippo pathway core components (MST1/2, LATS1/2, YAP and TAZ) is important for development and tissue …
Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis.
Wang P, Geng J, Gao J, Zhao H, Li J, Shi Y, Yang B, Xiao C, Linghu Y, Sun X, Chen X, Hong L, Qin F, Li X, Yu JS, You H, Yuan Z, Zhou D, Johnson RL, Chen L. Wang P, et al. Nat Commun. 2019 Feb 14;10(1):755. doi: 10.1038/s41467-019-08680-6. Nat Commun. 2019. PMID: 30765703 Free PMC article.
However, the cellular self-protective mechanism against such potential damage from oxidative stress remains unclear. Here we show that the kinases Mst1 and Mst2 (Mst1/2) sense ROS and maintain cellular redox balance by modulating the stability of antioxidant transcr …
However, the cellular self-protective mechanism against such potential damage from oxidative stress remains unclear. Here we show that the k …
Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling.
Zhang M, Lin J, Wang S, Cheng Z, Hu J, Wang T, Man W, Yin T, Guo W, Gao E, Reiter RJ, Wang H, Sun D. Zhang M, et al. J Pineal Res. 2017 Sep;63(2). doi: 10.1111/jpi.12418. Epub 2017 Jun 9. J Pineal Res. 2017. PMID: 28480597
To verify this hypothesis, a DCM model using Mst1 transgenic (Mst1 Tg) and Mst1 knockout (Mst1(-/-) ) mice was constructed. As expected, melatonin increased autophagy, reduced apoptosis and improved mitochondrial biogenesis in Mst1 Tg mice subje …
To verify this hypothesis, a DCM model using Mst1 transgenic (Mst1 Tg) and Mst1 knockout (Mst1(-/-) ) mice was c …
Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration.
Fan F, He Z, Kong LL, Chen Q, Yuan Q, Zhang S, Ye J, Liu H, Sun X, Geng J, Yuan L, Hong L, Xiao C, Zhang W, Sun X, Li Y, Wang P, Huang L, Wu X, Ji Z, Wu Q, Xia NS, Gray NS, Chen L, Yun CH, Deng X, Zhou D. Fan F, et al. Sci Transl Med. 2016 Aug 17;8(352):352ra108. doi: 10.1126/scitranslmed.aaf2304. Sci Transl Med. 2016. PMID: 27535619
The Hippo pathway is a key regulator of organ size and regeneration by inhibiting cell proliferation and promoting apoptosis. Kinases MST1 and MST2 (MST1/2), the mammalian Hippo orthologs, are central components of this pathway and are, therefore, strong target cand …
The Hippo pathway is a key regulator of organ size and regeneration by inhibiting cell proliferation and promoting apoptosis. Kinases MST
Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells.
Du X, Wen J, Wang Y, Karmaus PWF, Khatamian A, Tan H, Li Y, Guy C, Nguyen TM, Dhungana Y, Neale G, Peng J, Yu J, Chi H. Du X, et al. Nature. 2018 Jun;558(7708):141-145. doi: 10.1038/s41586-018-0177-0. Epub 2018 May 30. Nature. 2018. PMID: 29849151 Free PMC article.
Here we use a data-driven systems biology algorithm (NetBID) to identify a role of the Hippo pathway kinases Mst1 and Mst2 (Mst1/2) in selectively programming CD8alpha(+) dendritic cell function and metabolism. ...Mst1/2-deficient CD8alpha(+) dendritic cells …
Here we use a data-driven systems biology algorithm (NetBID) to identify a role of the Hippo pathway kinases Mst1 and Mst2 (Mst1
Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma.
Kim W, Khan SK, Liu Y, Xu R, Park O, He Y, Cha B, Gao B, Yang Y. Kim W, et al. Gut. 2018 Sep;67(9):1692-1703. doi: 10.1136/gutjnl-2017-314061. Epub 2017 Sep 2. Gut. 2018. PMID: 28866620 Free PMC article.
Macrophage ablation or deletion of Mcp1 in DKO mice markedly reduced hepatic inflammation and HCC development. ...CONCLUSIONS: Hippo signalling in hepatocytes maintains normal liver growth by suppressing macrophage infiltration during protumoural microenvironment fo
Macrophage ablation or deletion of Mcp1 in DKO mice markedly reduced hepatic inflammation and HCC development. ...CONCLUSIONS: Hippo
Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement.
Wang T, Zhang L, Hu J, Duan Y, Zhang M, Lin J, Man W, Pan X, Jiang Z, Zhang G, Gao B, Wang H, Sun D. Wang T, et al. J Mol Cell Cardiol. 2016 Sep;98:108-16. doi: 10.1016/j.yjmcc.2016.08.002. Epub 2016 Aug 3. J Mol Cell Cardiol. 2016. PMID: 27496379
Mst1 knockdown decreased, while Mst1 overexpression increased macrophage apoptosis upon ox-LDL exposure. ...Mst1 may participate in atherosclerosis progression through inhibition of macrophage autophagy and promotion of macrophage apoptos
Mst1 knockdown decreased, while Mst1 overexpression increased macrophage apoptosis upon ox-LDL exposure. ...Mst1
Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy.
Zhou T, Chang L, Luo Y, Zhou Y, Zhang J. Zhou T, et al. Redox Biol. 2019 Feb;21:101120. doi: 10.1016/j.redox.2019.101120. Epub 2019 Jan 23. Redox Biol. 2019. PMID: 30708325 Free PMC article.
However, the contribution and regulatory mechanisms of Parkin-related mitophagy in NAFLD are incompletely understood. Macrophage stimulating 1 (Mst1) is a novel mitophagy upstream regulator which excerbates heart and cancer apoptosisn via repressing mitophagy …
However, the contribution and regulatory mechanisms of Parkin-related mitophagy in NAFLD are incompletely understood. Macrophage s
Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2.
Maejima Y, Kyoi S, Zhai P, Liu T, Li H, Ivessa A, Sciarretta S, Del Re DP, Zablocki DK, Hsu CP, Lim DS, Isobe M, Sadoshima J. Maejima Y, et al. Nat Med. 2013 Nov;19(11):1478-88. doi: 10.1038/nm.3322. Epub 2013 Oct 20. Nat Med. 2013. PMID: 24141421 Free PMC article.
Here we show that Mst1, a proapoptotic kinase, impairs protein quality control mechanisms in the heart through inhibition of autophagy. ...Furthermore, Mst1-induced sequestration of Bcl-2 and Bcl-xL by Beclin1 allows Bax to become active, thereby stimulating
Here we show that Mst1, a proapoptotic kinase, impairs protein quality control mechanisms in the heart through inhibition of autophag …
MST1/MST2 Protein Kinases: Regulation and Physiologic Roles.
Galan JA, Avruch J. Galan JA, et al. Biochemistry. 2016 Oct 4;55(39):5507-5519. doi: 10.1021/acs.biochem.6b00763. Epub 2016 Sep 26. Biochemistry. 2016. PMID: 27618557 Free PMC article. Review.
The MST1 and MST2 protein kinases comprise the GCK-II subfamily of protein kinases. ...The growing list of candidate MST1/MST2 substrates suggests that the full range of MST1/MST2's physiologic programs and contributions to pathophysiology remains to be eluci …
The MST1 and MST2 protein kinases comprise the GCK-II subfamily of protein kinases. ...The growing list of candidate MST1/MST2 …
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