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Genetic associations of inflammatory bowel disease in a South Asian population.
Niriella MA, Liyanage IK, Kodisinghe SK, Silva AP, Rajapakshe N, Nanayakkara SD, Luke D, Silva T, Nawarathne M, Peiris RK, Kalubovila UP, Kumarasena SR, Dissanayake VHW, Jayasekara RW, de Silva HJ. Niriella MA, et al. World J Clin Cases. 2018 Dec 6;6(15):908-915. doi: 10.12998/wjcc.v6.i15.908. World J Clin Cases. 2018. PMID: 30568945 Free PMC article.
AIM: To estimate prevalence and phenotypic associations of selected inflammatory bowel disease (IBD)-associated genetic variants among Sri Lankan patients. ...Most SNPs and disease associations reported here have not been described in South Asians....
AIM: To estimate prevalence and phenotypic associations of selected inflammatory bowel disease (IBD)-associated genetic …
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study.
Cleynen I, Boucher G, Jostins L, Schumm LP, Zeissig S, Ahmad T, Andersen V, Andrews JM, Annese V, Brand S, Brant SR, Cho JH, Daly MJ, Dubinsky M, Duerr RH, Ferguson LR, Franke A, Gearry RB, Goyette P, Hakonarson H, Halfvarson J, Hov JR, Huang H, Kennedy NA, Kupcinskas L, Lawrance IC, Lee JC, Satsangi J, Schreiber S, Théâtre E, van der Meulen-de Jong AE, Weersma RK, Wilson DC; International Inflammatory Bowel Disease Genetics Consortium, Parkes M, Vermeire S, Rioux JD, Mansfield J, Silverberg MS, Radford-Smith G, McGovern DP, Barrett JC, Lees CW. Cleynen I, et al. Lancet. 2016 Jan 9;387(10014):156-67. doi: 10.1016/S0140-6736(15)00465-1. Epub 2015 Oct 18. Lancet. 2016. PMID: 26490195 Free PMC article. Clinical Trial.
We undertook the largest genotype association study, to date, in widely used clinical subphenotypes of inflammatory bowel disease with the goal of further understanding the biological relations between diseases. ...Three loci (NOD2, MHC, and MST1
We undertook the largest genotype association study, to date, in widely used clinical subphenotypes of inflammatory bowel d
Inflammatory bowel disease (IBD) locus 12: is glutathione peroxidase-1 (GPX1) the relevant gene?
Häuser F, Rossmann H, Laubert-Reh D, Wild PS, Zeller T, Müller C, Neuwirth S, Blankenberg S, Lackner KJ. Häuser F, et al. Genes Immun. 2015 Dec;16(8):571-5. doi: 10.1038/gene.2015.35. Epub 2015 Sep 10. Genes Immun. 2015. PMID: 26355565
Genome-wide association studies have identified and repeatedly confirmed the association of rs3197999 in MST1 with inflammatory bowel disease (IBD). However, the underlying pathophysiology remains unclear. rs3197999 is a non-synonymous single-nucleotid …
Genome-wide association studies have identified and repeatedly confirmed the association of rs3197999 in MST1 with inflammatory
Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.
Kauder SE, Santell L, Mai E, Wright LY, Luis E, N'Diaye EN, Lutman J, Ratti N, Sa SM, Maun HR, Stefanich E, Gonzalez LC, Graham RR, Diehl L, Faubion WA Jr, Keir ME, Young J, Chaudhuri A, Lazarus RA, Egen JG. Kauder SE, et al. PLoS One. 2013 Dec 23;8(12):e83958. doi: 10.1371/journal.pone.0083958. eCollection 2013. PLoS One. 2013. PMID: 24409221 Free PMC article.
BACKGROUND: Macrophage stimulating protein (MSP) is a serum growth factor that binds to and activates the receptor tyrosine kinase, Recepteur d'Origine Nantais (RON). A non-synonymous coding variant in MSP (689C) has been associated with genetic susceptibility to bo …
BACKGROUND: Macrophage stimulating protein (MSP) is a serum growth factor that binds to and activates the receptor tyrosine ki …
DNA-driven nutritional therapy of inflammatory bowel disease.
Lee G, Buchman AL. Lee G, et al. Nutrition. 2009 Sep;25(9):885-91. doi: 10.1016/j.nut.2009.06.011. Nutrition. 2009. PMID: 19647622 Review.
Inflammatory bowel disease (IBD) consists of two main disorders, ulcerative colitis and Crohn's disease, that cause chronic, recurrent inflammation of the intestine. ...Crohn's disease shows strong association with CARD15, ATG15L1, and IRGM, whi
Inflammatory bowel disease (IBD) consists of two main disorders, ulcerative colitis and Crohn's disease, that ca
Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility.
Márquez A, Cénit MC, Núñez C, Mendoza JL, Taxonera C, Díaz-Rubio M, Bartolomé M, Arroyo R, Fernández-Arquero M, de la Concha EG, Urcelay E. Márquez A, et al. Genes Immun. 2009 Oct;10(7):631-5. doi: 10.1038/gene.2009.56. Epub 2009 Aug 6. Genes Immun. 2009. PMID: 19657358
Genome-wide studies highlighted the effect in Crohn's disease (CD) and ulcerative colitis (UC) susceptibility of single nucleotide polymorphisms (SNPs) in 3p21, where BSN (bassoon), MST1 (macrophage stimulating-1) and MST1R (MST1 Receptor) genes …
Genome-wide studies highlighted the effect in Crohn's disease (CD) and ulcerative colitis (UC) susceptibility of single nucleotide po …
Deficiency in macrophage-stimulating protein results in spontaneous intestinal inflammation and increased susceptibility toward epithelial damage in zebrafish.
Witte M, Huitema LF, Nieuwenhuis EE, Brugman S. Witte M, et al. Zebrafish. 2014 Dec;11(6):542-50. doi: 10.1089/zeb.2014.1023. Zebrafish. 2014. PMID: 25353089
Several genome-wide association studies have identified the genes encoding for macrophage-stimulating protein (MSP) and its receptor RON (Recepteur d'Origine Nantais) as possible susceptibility factors in inflammatory bowel disease. ...From 14 t …
Several genome-wide association studies have identified the genes encoding for macrophage-stimulating protein (MSP) and its re …
Macrophage-stimulating protein polymorphism rs3197999 is associated with a gain of function: implications for inflammatory bowel disease.
Häuser F, Deyle C, Berard D, Neukirch C, Glowacki C, Bickmann JK, Wenzel JJ, Lackner KJ, Rossmann H. Häuser F, et al. Genes Immun. 2012 Jun;13(4):321-7. doi: 10.1038/gene.2011.88. Epub 2012 Jan 12. Genes Immun. 2012. PMID: 22237417
Crohn's disease and ulcerative colitis, the two main types of inflammatory bowel disease (IBD), were reported to be associated with a variety of genetic polymorphisms. ...A broad set of evidence reported previously suggests that pro-inflammatory
Crohn's disease and ulcerative colitis, the two main types of inflammatory bowel disease (IBD), were reported to …
A novel susceptibility locus in MST1 and gene-gene interaction network for Crohn's disease in the Chinese population.
Wu WKK, Sun R, Zuo T, Tian Y, Zeng Z, Ho J, Wu JCY, Chan FKL, Chan MTV, Yu J, Sung JJY, Wong SH, Wang MH, Ng SC. Wu WKK, et al. J Cell Mol Med. 2018 Apr;22(4):2368-2377. doi: 10.1111/jcmm.13530. Epub 2018 Feb 14. J Cell Mol Med. 2018. PMID: 29441677 Free PMC article.
JAK2 rs1159782 (T>C) was also strongly associated with Crohn's disease (P = 2.34 × 10(-4) ; odds ratio = 3.72). Gene-gene interaction analysis revealed significant interactions between MST1 and other susceptibility genes, including NOD2, MUC19 and ATG16L1 in cont …
JAK2 rs1159782 (T>C) was also strongly associated with Crohn's disease (P = 2.34 × 10(-4) ; odds ratio = 3.72). Gene-gene interact …
Advances and controversies in the pathogenesis and management of primary sclerosing cholangitis.
Eksteen B. Eksteen B. Br Med Bull. 2014 Jun;110(1):89-98. doi: 10.1093/bmb/ldu008. Epub 2014 May 2. Br Med Bull. 2014. PMID: 24795363 Review.
INTRODUCTION: Primary sclerosing cholangitis (PSC) is a chronic immune-mediated liver disease that results in end-stage liver disease requiring liver transplantation. PSC is closely associated with inflammatory bowel disease (IBD) with 70% of pa …
INTRODUCTION: Primary sclerosing cholangitis (PSC) is a chronic immune-mediated liver disease that results in end-stage liver dise
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