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1988 1
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2003 19
2004 21
2005 31
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2008 54
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NOD1 and NOD2: signaling, host defense, and inflammatory disease.
Caruso R, Warner N, Inohara N, Núñez G. Caruso R, et al. Immunity. 2014 Dec 18;41(6):898-908. doi: 10.1016/j.immuni.2014.12.010. Epub 2014 Dec 6. Immunity. 2014. PMID: 25526305 Free PMC article. Review.
Several routes for the entry of peptidoglycan ligands to the host cytosol to trigger activation of NOD1 and NOD2 have been elucidated. ...Further understanding of NOD1 and NOD2 should provide new insight into the pathogenesis of disease and the development of new st …
Several routes for the entry of peptidoglycan ligands to the host cytosol to trigger activation of NOD1 and NOD2 have been elucidated …
NOD1 and NOD2 in inflammation, immunity and disease.
Mukherjee T, Hovingh ES, Foerster EG, Abdel-Nour M, Philpott DJ, Girardin SE. Mukherjee T, et al. Arch Biochem Biophys. 2019 Jul 30;670:69-81. doi: 10.1016/j.abb.2018.12.022. Epub 2018 Dec 19. Arch Biochem Biophys. 2019. PMID: 30578751 Review.
NOD1 and NOD2 are related intracellular sensors of bacterial peptidoglycan and belong to the Nod-like receptor (NLR) family of innate immune proteins that play fundamental and pleiotropic roles in host defense against infection and in the control of inflammation. ...At the
NOD1 and NOD2 are related intracellular sensors of bacterial peptidoglycan and belong to the Nod-like receptor (NLR) family of innate
Nod1 Imprints Inflammatory and Carcinogenic Responses toward the Gastric Pathogen Helicobacter pylori.
Suarez G, Romero-Gallo J, Piazuelo MB, Sierra JC, Delgado AG, Washington MK, Shah SC, Wilson KT, Peek RM Jr. Suarez G, et al. Cancer Res. 2019 Apr 1;79(7):1600-1611. doi: 10.1158/0008-5472.CAN-18-2651. Epub 2019 Jan 29. Cancer Res. 2019. PMID: 30696658 Free PMC article.
Infected C57BL/6 (Nod1-/-) and INS-GAS (Nod1-/-) mice acutely developed more severe gastritis, and INS-GAS (Nod1-/-) mice developed gastric dysplasia more frequently compared with Nod1(+/+) mice. ...Furthermore, H. pylori infection altered the polariza …
Infected C57BL/6 (Nod1-/-) and INS-GAS (Nod1-/-) mice acutely developed more severe gastritis, and INS-GAS (Nod1-/-) mi …
NOD1: An Interface Between Innate Immunity and Insulin Resistance.
Rivers SL, Klip A, Giacca A. Rivers SL, et al. Endocrinology. 2019 May 1;160(5):1021-1030. doi: 10.1210/en.2018-01061. Endocrinology. 2019. PMID: 30807635 Free PMC article. Review.
In vivo studies have demonstrated that NOD1 activation induces peripheral, hepatic, and whole-body insulin resistance. Also, NOD1-deficient models are protected from high-fat diet (HFD)-induced insulin resistance. ...Nevertheless, that NOD1 contributes to the …
In vivo studies have demonstrated that NOD1 activation induces peripheral, hepatic, and whole-body insulin resistance. Also, NOD1
Endothelial NOD1 directs myeloid cell recruitment in atherosclerosis through VCAM-1.
González-Ramos S, Paz-García M, Rius C, Del Monte-Monge A, Rodríguez C, Fernández-García V, Andrés V, Martínez-González J, Lasunción MA, Martín-Sanz P, Soehnlein O, Boscá L. González-Ramos S, et al. FASEB J. 2019 Mar;33(3):3912-3921. doi: 10.1096/fj.201801231RR. Epub 2018 Nov 29. FASEB J. 2019. PMID: 30496704
Our data define a major proatherogenic role for endothelial NOD1 in early leukocyte recruitment to the athero-prone vasculature, thus introducing NOD1 as an innovative therapeutic target and potential prognostic molecule....Endothelial NOD1 directs myeloid ce …
Our data define a major proatherogenic role for endothelial NOD1 in early leukocyte recruitment to the athero-prone vasculature, thus …
NOD1 and NOD2: Beyond Peptidoglycan Sensing.
Keestra-Gounder AM, Tsolis RM. Keestra-Gounder AM, et al. Trends Immunol. 2017 Oct;38(10):758-767. doi: 10.1016/j.it.2017.07.004. Epub 2017 Aug 16. Trends Immunol. 2017. PMID: 28823510 Free PMC article. Review.
NOD1 and NOD2 are pattern recognition receptors of the innate immune system with well-established roles in sensing fragments of bacterial peptidoglycan. ...Indeed, recent work has expanded the roles of NOD1 and NOD2 to encompass not only sensing of infections with v
NOD1 and NOD2 are pattern recognition receptors of the innate immune system with well-established roles in sensing fragments of bacte
Immunopathogenesis of pancreatitis.
Watanabe T, Kudo M, Strober W. Watanabe T, et al. Mucosal Immunol. 2017 Mar;10(2):283-298. doi: 10.1038/mi.2016.101. Epub 2016 Nov 16. Mucosal Immunol. 2017. PMID: 27848953 Review.
Quite unexpectedly, these recent studies reveal that the innate responses involve activation of responses by an innate factor, nucleotide-binding oligomerization domain 1 (NOD1), and that such NOD1 responses have a critical role in the activation/production of nucle …
Quite unexpectedly, these recent studies reveal that the innate responses involve activation of responses by an innate factor, nucleotide-bi …
Role of NOD1 in Heart Failure Progression via Regulation of Ca(2+) Handling.
Val-Blasco A, Piedras MJGM, Ruiz-Hurtado G, Suarez N, Prieto P, Gonzalez-Ramos S, Gómez-Hurtado N, Delgado C, Pereira L, Benito G, Zaragoza C, Domenech N, Crespo-Leiro MG, Vasquez-Echeverri D, Nuñez G, Lopez-Collazo E, Boscá L, Fernández-Velasco M. Val-Blasco A, et al. J Am Coll Cardiol. 2017 Jan 31;69(4):423-433. doi: 10.1016/j.jacc.2016.10.073. J Am Coll Cardiol. 2017. PMID: 28126160 Free article.
OBJECTIVES: This study evaluated the role of NOD1 in HF progression. METHODS: NOD1 was examined in human failing myocardium and in a post-myocardial infarction (PMI) HF model evaluated in wild-type (wt-PMI) and Nod1(-/-) mice (Nod1(-/-)-PMI). RESULTS: …
OBJECTIVES: This study evaluated the role of NOD1 in HF progression. METHODS: NOD1 was examined in human failing myocardium an …
The role of NOD1/CARD4 and NOD2/CARD15 genetic variations in lung cancer risk.
Ozbayer C, Kurt H, Bayramoglu A, Gunes HV, Metintas M, Degirmenci İ, Oner KS. Ozbayer C, et al. Inflamm Res. 2015 Oct;64(10):775-9. doi: 10.1007/s00011-015-0859-0. Epub 2015 Aug 4. Inflamm Res. 2015. PMID: 26238283
BACKGROUND AND AIM: NOD1/CARD4 and NOD2/CARD15 are members of the Nod-like receptor (NLR) family, and they contain a caspase recruitment domain (CARD). ...NOD1/CARD4 and NOD2/CARD15 gene polymorphisms may also be associated with altered risks for many …
BACKGROUND AND AIM: NOD1/CARD4 and NOD2/CARD15 are members of the Nod-like receptor (NLR) family, and they contain a caspase r …
Higher Expression of NOD1 and NOD2 is Associated with Vogt-Koyanagi-Harada (VKH) Syndrome But Not Behcet's Disease (BD).
Deng B, Ye Z, Li L, Zhang D, Zhu Y, He Y, Wang C, Wu L, Kijlstra A, Yang P. Deng B, et al. Curr Mol Med. 2016;16(4):424-35. doi: 10.2174/1566524016666160316153038. Curr Mol Med. 2016. PMID: 26980698
NOD1 and NOD2 have been found to play a significant regulatory role in autoimmune disease. To analyze the role of NOD1 and NOD2 in the pathogenesis of Vogt- Koyanagi-Harada (VKH) syndrome and Behcet's disease (BD). ...Our results suggest that over-expression of N
NOD1 and NOD2 have been found to play a significant regulatory role in autoimmune disease. To analyze the role of NOD1 and NOD
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