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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1976 2
1977 1
1980 1
1981 2
1982 2
1983 1
1984 1
1985 6
1986 5
1987 4
1988 5
1989 4
1990 4
1991 8
1992 7
1993 10
1994 15
1995 7
1996 9
1997 12
1998 11
1999 9
2000 16
2001 26
2002 44
2003 57
2004 70
2005 80
2006 113
2007 137
2008 184
2009 210
2010 278
2011 294
2012 342
2013 494
2014 655
2015 1083
2016 1661
2017 2439
2018 3055
2019 3681
2020 3475
2021 4
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16,838 results
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Page 1
PD-1 and its ligands in tolerance and immunity.
Keir ME, Butte MJ, Freeman GJ, Sharpe AH. Keir ME, et al. Annu Rev Immunol. 2008;26:677-704. doi: 10.1146/annurev.immunol.26.021607.090331. Annu Rev Immunol. 2008. PMID: 18173375 Review.
Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, deliver inhibitory signals that regulate the balance between T cell activation, tolerance, and immunopathology. ...The identification of B7-1 as an additional binding partner for …
Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, deliver inhibitory signals that regulate the …
Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure).
Kim JM, Chen DS. Kim JM, et al. Ann Oncol. 2016 Aug;27(8):1492-504. doi: 10.1093/annonc/mdw217. Epub 2016 May 20. Ann Oncol. 2016. PMID: 27207108 Free article. Review.
The emergence of programmed death-ligand 1 (PD-L1)/programmed death-1 (PD-1)-targeted therapy has demonstrated the importance of the PD-L1 : PD-1 interaction in inhibiting anticancer T-cell immunity in multiple human cancers …
The emergence of programmed death-ligand 1 (PD-L1)/programmed death-1 (PD-1)-targeted therapy has demonst …
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity.
Gordon SR, Maute RL, Dulken BW, Hutter G, George BM, McCracken MN, Gupta R, Tsai JM, Sinha R, Corey D, Ring AM, Connolly AJ, Weissman IL. Gordon SR, et al. Nature. 2017 May 25;545(7655):495-499. doi: 10.1038/nature22396. Epub 2017 May 17. Nature. 2017. PMID: 28514441 Free PMC article.
Tumour cells frequently overexpress the ligand for PD-1, programmed cell death ligand 1 (PD-L1), facilitating their escape from the immune system. ...Here we show that both mouse and human TAMs express PD-1. TAM PD-1 express …
Tumour cells frequently overexpress the ligand for PD-1, programmed cell death ligand 1 (PD-L1), facilitating th …
PD-1/PD-L1 Pathway in Breast Cancer.
Schütz F, Stefanovic S, Mayer L, von Au A, Domschke C, Sohn C. Schütz F, et al. Oncol Res Treat. 2017;40(5):294-297. doi: 10.1159/000464353. Epub 2017 Mar 27. Oncol Res Treat. 2017. PMID: 28346916 Free article. Review.
The programmed cell death-1 receptor (PD-1) is an immune checkpoint inhibitor which is expressed on the surface of immune effector cells. It is activated mainly by PD-L1 which can be expressed by all human cells. The PD-1/PD-L1 pat …
The programmed cell death-1 receptor (PD-1) is an immune checkpoint inhibitor which is expressed on the surface of immu …
PD-L1.
Kythreotou A, Siddique A, Mauri FA, Bower M, Pinato DJ. Kythreotou A, et al. J Clin Pathol. 2018 Mar;71(3):189-194. doi: 10.1136/jclinpath-2017-204853. Epub 2017 Nov 2. J Clin Pathol. 2018. PMID: 29097600 Free article. Review.
Programmed death ligand 1 (PD-L1) is the principal ligand of programmed death 1 (PD-1), a coinhibitory receptor that can be constitutively expressed or induced in myeloid, lymphoid, normal epithelial cells and in cancer. ...PD-L1 expressi …
Programmed death ligand 1 (PD-L1) is the principal ligand of programmed death 1 (PD-1), a coinhibitory re …
PD-1 and PD-1 ligands: from discovery to clinical application.
Okazaki T, Honjo T. Okazaki T, et al. Int Immunol. 2007 Jul;19(7):813-24. doi: 10.1093/intimm/dxm057. Epub 2007 Jul 2. Int Immunol. 2007. PMID: 17606980 Review.
Programmed cell death-1 (PD-1, Pdcd1), an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or …
Programmed cell death-1 (PD-1, Pdcd1), an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulate …
PDCD1 PD-1.3 polymorphism and allergic bronchial asthma in Russian and Buryat patients.
Dmitrieva-Zdorova EV, Gabaeva MV, Seregin YA, Bodoev NV, Voronko OE. Dmitrieva-Zdorova EV, et al. J Asthma. 2017 Jan 2;54(1):46-52. doi: 10.1080/02770903.2016.1196366. Epub 2016 Jun 10. J Asthma. 2017. PMID: 27286421
OBJECTIVE: The programmed death-1 receptor, PD-1, is a negative regulator of T-cell activation. The PD-1.3 polymorphism of the PD-1 gene (PDCD1) has been previously shown to be associated with several autoimmune and inflamma …
OBJECTIVE: The programmed death-1 receptor, PD-1, is a negative regulator of T-cell activation. The PD-1. …
PD-1 (PDCD1) Promoter Methylation Is a Prognostic Factor in Patients With Diffuse Lower-Grade Gliomas Harboring Isocitrate Dehydrogenase (IDH) Mutations.
Röver LK, Gevensleben H, Dietrich J, Bootz F, Landsberg J, Goltz D, Dietrich D. Röver LK, et al. EBioMedicine. 2018 Feb;28:97-104. doi: 10.1016/j.ebiom.2018.01.016. Epub 2018 Jan 31. EBioMedicine. 2018. PMID: 29396294 Free PMC article.
Furthermore, immune checkpoint methylation was significantly associated with age (PD-L2: p=0.003; PD-1: p=0.015), molecular alterations, i.e. MGMT methylation (PD-L1: p<0.001; PD-L2: p<0.001), ATRX mutations (PD-L2: p<0.001, P
Furthermore, immune checkpoint methylation was significantly associated with age (PD-L2: p=0.003; PD-1: p=0.015), molec …
PD-1/PD-L1 in disease.
Kuol N, Stojanovska L, Nurgali K, Apostolopoulos V. Kuol N, et al. Immunotherapy. 2018 Feb;10(2):149-160. doi: 10.2217/imt-2017-0120. Immunotherapy. 2018. PMID: 29260623
AIM: Expression of PD-1 on T/B cells regulates peripheral tolerance and autoimmunity. Binding of PD-1 to its ligand, PD-L1, leads to protection against self-reactivity. ...PD-L1 and PD-1 blockade using antibodies are in huma …
AIM: Expression of PD-1 on T/B cells regulates peripheral tolerance and autoimmunity. Binding of PD-1 to its lig …
PD-L2 is a second ligand for PD-1 and inhibits T cell activation.
Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, Freeman GJ. Latchman Y, et al. Nat Immunol. 2001 Mar;2(3):261-8. doi: 10.1038/85330. Nat Immunol. 2001. PMID: 11224527
We identify here PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. ...At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 si …
We identify here PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expressio …
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