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1997 1
1998 2
1999 1
2000 3
2001 2
2002 2
2003 11
2004 13
2005 15
2006 14
2007 12
2008 21
2009 25
2010 19
2011 11
2012 11
2013 17
2014 19
2015 22
2016 11
2017 23
2018 19
2019 15
2020 6
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Loss of PDZK1 expression activates PI3K/AKT signaling via PTEN phosphorylation in gastric cancer.
Zhao C, Tao T, Yang L, Qin Q, Wang Y, Liu H, Song R, Yang X, Wang Q, Gu S, Xiong Y, Zhao D, Wang S, Feng D, Jiang WG, Zhang J, He J. Zhao C, et al. Cancer Lett. 2019 Jul 1;453:107-121. doi: 10.1016/j.canlet.2019.03.043. Epub 2019 Mar 29. Cancer Lett. 2019. PMID: 30930234
In the present study, PDZK1 was identified as a novel binding protein of PTEN by association of PTEN through its carboxyl terminus and PDZ domains of PDZK1. ...Downregulation of PDZK1 was associated with PTEN inactivation, AKT signaling and cell proliferation …
In the present study, PDZK1 was identified as a novel binding protein of PTEN by association of PTEN through its carboxyl terminus an …
The nuclear receptors PXR and LXR are regulators of the scaffold protein PDZK1.
Ferreira C, Meyer R, Meyer Zu Schwabedissen HE. Ferreira C, et al. Biochim Biophys Acta Gene Regul Mech. 2019 Apr;1862(4):447-456. doi: 10.1016/j.bbagrm.2019.02.007. Epub 2019 Mar 1. Biochim Biophys Acta Gene Regul Mech. 2019. PMID: 30831268
PDZK1 (NHERF3) interacts with membrane proteins whereby modulating their spatial arrangement, membrane stability, and function. ...Further, we located the most likely binding site for LXRα and PXR on the PDZK1 promoter between -85 bp and -54 bp. The transcriptional
PDZK1 (NHERF3) interacts with membrane proteins whereby modulating their spatial arrangement, membrane stability, and function. ...Fu
Soluble uric acid increases PDZK1 and ABCG2 expression in human intestinal cell lines via the TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway.
Chen M, Lu X, Lu C, Shen N, Jiang Y, Chen M, Wu H. Chen M, et al. Arthritis Res Ther. 2018 Feb 7;20(1):20. doi: 10.1186/s13075-018-1512-4. Arthritis Res Ther. 2018. PMID: 29415757 Free PMC article.
Small interfering RNA transfection was used to assess the interaction between ABCG2 and PDZ domain-containing 1 (PDZK1). RESULTS: Soluble uric acid increased the expression of PDZK1 and ABCG2. ...Furthermore, PDZK1 knockdown significantly inhibited the expres …
Small interfering RNA transfection was used to assess the interaction between ABCG2 and PDZ domain-containing 1 (PDZK1). RESULTS: Sol …
PDZK1 in leukocytes protects against cellular apoptosis and necrotic core development in atherosclerotic plaques in high fat diet fed ldl receptor deficient mice.
Yu P, Qian AS, Chathely KM, Trigatti BL. Yu P, et al. Atherosclerosis. 2018 Sep;276:171-181. doi: 10.1016/j.atherosclerosis.2018.05.009. Epub 2018 May 16. Atherosclerosis. 2018. PMID: 29853191 Free article.
Complete knockout of pdzk1 increases atherosclerosis in apoE-deficient mice, but the effect of PDZK1 in leukocytes is not known. ...METHODS: Ldlr(-/-) mice were transplanted with either pdzk1(-/-) or pdzk1(+/+) bone marrow and fed a high-fat diet to in …
Complete knockout of pdzk1 increases atherosclerosis in apoE-deficient mice, but the effect of PDZK1 in leukocytes is not know …
SR-B1 and PDZK1: partners in HDL regulation.
Trigatti BL. Trigatti BL. Curr Opin Lipidol. 2017 Apr;28(2):201-208. doi: 10.1097/MOL.0000000000000396. Curr Opin Lipidol. 2017. PMID: 28134663 Review.
RECENT FINDINGS: Much of our understanding of the physiological roles of SR-B1 and PDZK1 in HDL metabolism and atherosclerosis comes from studies of genetically manipulated mice. ...Other rare mutations in both the human SCARB1 and PDZK1 genes remain to be character …
RECENT FINDINGS: Much of our understanding of the physiological roles of SR-B1 and PDZK1 in HDL metabolism and atherosclerosis comes …
Data on leukocyte PDZK1 deficiency affecting macrophage apoptosis but not monocyte recruitment, cell proliferation, macrophage abundance or ER stress in atherosclerotic plaques of LDLR deficient mice.
Yu P, Qian AS, Chathely KM, Trigatti BL. Yu P, et al. Data Brief. 2018 May 26;19:1148-1161. doi: 10.1016/j.dib.2018.05.128. eCollection 2018 Aug. Data Brief. 2018. PMID: 30246067 Free PMC article.
However, this protection afforded by HDL was lost when macrophages were deficient in PDZK1. HDL did not affect the level of ER stress induction by tunicamycin. Finally, PDZK1 deficiency in macrophages did not affect lipopolysaccharide-mediated induction of markers o …
However, this protection afforded by HDL was lost when macrophages were deficient in PDZK1. HDL did not affect the level of ER stress …
The scaffold protein PDZK1 modulates expression and function of the organic anion transporting polypeptide 2B1.
Ferreira C, Hagen P, Stern M, Hussner J, Zimmermann U, Grube M, Meyer Zu Schwabedissen HE. Ferreira C, et al. Eur J Pharm Sci. 2018 Jul 30;120:181-190. doi: 10.1016/j.ejps.2018.05.006. Epub 2018 May 9. Eur J Pharm Sci. 2018. PMID: 29752999
Finally, deletion of the C-terminal PDZ-binding motif in OATP2B1 lowered the impact of PDZK1 on transport function. Taken together, we report an interaction of PDZK1 with OATP2B1, which influences localization and function of the transporter. Changes in PDZK1
Finally, deletion of the C-terminal PDZ-binding motif in OATP2B1 lowered the impact of PDZK1 on transport function. Taken together, w …
An eight-case 1q21 region series: novel aberrations and clinical variability with new features.
Ceylan AC, Sahin I, Erdem HB, Kayhan G, Simsek-Kiper PO, Utine GE, Percin F, Boduroglu K, Alikasifoglu M. Ceylan AC, et al. J Intellect Disabil Res. 2019 Jun;63(6):548-557. doi: 10.1111/jir.12592. Epub 2019 Feb 18. J Intellect Disabil Res. 2019. PMID: 30773728
One of the cases (case 7) presents moderate intellectual disability and dysmorphic facial findings, whereas chromosomal microarray analysis showed that case 7 had an 889-kb deletion in the 1q21 proximal region (GPR89A, PDZK1, CD160, POLR3C and NBPF12). ...
One of the cases (case 7) presents moderate intellectual disability and dysmorphic facial findings, whereas chromosomal microarray analysis …
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
Michailidou K, Beesley J, Lindstrom S, Canisius S, Dennis J, Lush MJ, Maranian MJ, Bolla MK, Wang Q, Shah M, Perkins BJ, Czene K, Eriksson M, Darabi H, Brand JS, Bojesen SE, Nordestgaard BG, Flyger H, Nielsen SF, Rahman N, Turnbull C; BOCS, Fletcher O, Peto J, Gibson L, dos-Santos-Silva I, Chang-Claude J, Flesch-Janys D, Rudolph A, Eilber U, Behrens S, Nevanlinna H, Muranen TA, Aittomäki K, Blomqvist C, Khan S, Aaltonen K, Ahsan H, Kibriya MG, Whittemore AS, John EM, Malone KE, Gammon MD, Santella RM, Ursin G, Makalic E, Schmidt DF, Casey G, Hunter DJ, Gapstur SM, Gaudet MM, Diver WR, Haiman CA, Schumacher F, Henderson BE, Le Marchand L, Berg CD, Chanock SJ, Figueroa J, Hoover RN, Lambrechts D, Neven P, Wildiers H, van Limbergen E, Schmidt MK, Broeks A, Verhoef S, Cornelissen S, Couch FJ, Olson JE, Hallberg E, Vachon C, Waisfisz Q, Meijers-Heijboer H, Adank MA, van der Luijt RB, Li J, Liu J, Humphreys K, Kang D, Choi JY, Park SK, Yoo KY, Matsuo K, Ito H, Iwata H, Tajima K, Guénel P, Truong T, Mulot C, Sanchez M, Burwinkel B, Marme F, Surowy H, Sohn C, Wu AH, Tseng CC, Van Den Berg D, Stram DO, González-Neira A, Benitez J, Zamora MP, Perez JI, Shu XO, Lu W, Gao YT, Cai H, Cox A, Cross SS, Reed MW, Andrulis IL, Knight JA, Glendon G, Mulligan AM, Sawyer EJ, Tomlinson I, Kerin MJ, Miller N; kConFab Investigators; AOCS Group, Lindblom A, Margolin S, Teo SH, Yip CH, Taib NA, Tan GH, Hooning MJ, Hollestelle A, Martens JW, Collée JM, Blot W, Signorello LB, Cai Q, Hopper JL, Southey MC, Tsimiklis H, Apicella C, Shen CY, Hsiung CN, Wu PE, Hou MF, Kristensen VN, Nord S, Alnaes GI; NBCS, Giles GG, Milne RL, McLean C, Canzian F, Trichopoulos D, Peeters P, Lund E, Sund M, Khaw KT, Gunter MJ, Palli D, Mortensen LM, Dossus L, Huerta JM, Meindl A, Schmutzler RK, Sutter C, Yang R, Muir K, Lophatananon A, Stewart-Brown S, Siriwanarangsan P, Hartman M, Miao H, Chia KS, Chan CW, Fasching PA, Hein A, Beckmann MW, Haeberle L, Brenner H, Dieffenbach AK, Arndt V, Stegmaier C, Ashworth A, Orr N, Schoemaker MJ, Swerdlow AJ, Brinton L, Garcia-Closas M, Zheng W, Halverson SL, Shrubsole M, Long J, Goldberg MS, Labrèche F, Dumont M, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M, Brauch H, Hamann U, Brüning T; GENICA Network, Radice P, Peterlongo P, Manoukian S, Bernard L, Bogdanova NV, Dörk T, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, Devilee P, Tollenaar RA, Seynaeve C, Van Asperen CJ, Jakubowska A, Lubinski J, Jaworska K, Huzarski T, Sangrajrang S, Gaborieau V, Brennan P, McKay J, Slager S, Toland AE, Ambrosone CB, Yannoukakos D, Kabisch M, Torres D, Neuhausen SL, Anton-Culver H, Luccarini C, Baynes C, Ahmed S, Healey CS, Tessier DC, Vincent D, Bacot F, Pita G, Alonso MR, Álvarez N, Herrero D, Simard J, Pharoah PP, Kraft P, Dunning AM, Chenevix-Trench G, Hall P, Easton DF. Michailidou K, et al. Nat Genet. 2015 Apr;47(4):373-80. doi: 10.1038/ng.3242. Epub 2015 Mar 9. Nat Genet. 2015. PMID: 25751625 Free PMC article.
Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. ...
Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCOD …
Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout.
Zhu W, Deng Y, Zhou X. Zhu W, et al. Open Rheumatol J. 2018 Jul 24;12:94-113. doi: 10.2174/1874312901812010094. eCollection 2018. Open Rheumatol J. 2018. PMID: 30123371 Free PMC article. Review.
Major genes that were associated with gout include URAT1, GLUT9, OAT4, NPT1 (SLC17A1), NPT4 (SLC17A3), NPT5 (SLC17A4), MCT9, ABCG2, ABCC4, KCNQ1, PDZK1, NIPAL1, IL1β, IL-8, IL-12B, IL-23R, TNFA, MCP-1/CCL2, NLRP3, PPARGC1B, TLR4, CD14, CARD8, P2X7R, EGF, A1CF, HNF4G and TR …
Major genes that were associated with gout include URAT1, GLUT9, OAT4, NPT1 (SLC17A1), NPT4 (SLC17A3), NPT5 (SLC17A4), MCT9, ABCG2, ABCC4, K …
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