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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
1993 8
1994 16
1995 27
1996 35
1997 51
1998 100
1999 130
2000 167
2001 236
2002 328
2003 344
2004 449
2005 638
2006 657
2007 800
2008 839
2009 845
2010 865
2011 845
2012 937
2013 1063
2014 986
2015 1027
2016 977
2017 1006
2018 1053
2019 1002
2020 941
2021 64
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14,359 results
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Page 1
Molecular Actions of PPARalpha in Lipid Metabolism and Inflammation.
Bougarne N, Weyers B, Desmet SJ, Deckers J, Ray DW, Staels B, De Bosscher K. Bougarne N, et al. Endocr Rev. 2018 Oct 1;39(5):760-802. doi: 10.1210/er.2018-00064. Endocr Rev. 2018. PMID: 30020428 Free article. Review.
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor of clinical interest as a drug target in various metabolic disorders. PPARalpha also exhibits marked anti-inflammatory capacities. The first-generation PPARalpha agonist …
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor of clinical interest as a drug target in va …
Molecular mechanism of PPARalpha action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease.
Pawlak M, Lefebvre P, Staels B. Pawlak M, et al. J Hepatol. 2015 Mar;62(3):720-33. doi: 10.1016/j.jhep.2014.10.039. Epub 2014 Nov 1. J Hepatol. 2015. PMID: 25450203 Free article. Review.
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a ligand-activated transcription factor belonging, together with PPARgamma and PPARbeta/delta, to the NR1C nuclear receptor subfamily. Many PPARalpha target genes are involved in fatty acid metab …
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a ligand-activated transcription factor belonging, together wi …
The role and regulation of the peroxisome proliferator activated receptor alpha in human liver.
Kersten S, Stienstra R. Kersten S, et al. Biochimie. 2017 May;136:75-84. doi: 10.1016/j.biochi.2016.12.019. Epub 2017 Jan 8. Biochimie. 2017. PMID: 28077274 Review.
The peroxisome proliferator-activated receptor alpha (PPARalpha) is a ligand-activated transcription factor that is abundantly expressed in liver. ...In addition, PPARalpha suppresses inflammation and the acute phase response. Comparatively little is known ab …
The peroxisome proliferator-activated receptor alpha (PPARalpha) is a ligand-activated transcription factor that is abundantly …
Nutrient-sensing nuclear receptors PPARalpha and FXR control liver energy balance.
Preidis GA, Kim KH, Moore DD. Preidis GA, et al. J Clin Invest. 2017 Apr 3;127(4):1193-1201. doi: 10.1172/JCI88893. Epub 2017 Mar 13. J Clin Invest. 2017. PMID: 28287408 Free PMC article. Review.
The nuclear receptors PPARalpha (encoded by NR1C1) and farnesoid X receptor (FXR, encoded by NR1H4) are activated in the liver in the fasted and fed state, respectively. ...Finally, previous studies demonstrated a striking deficiency in bile acid levels in malnourished mic …
The nuclear receptors PPARalpha (encoded by NR1C1) and farnesoid X receptor (FXR, encoded by NR1H4) are activated in the liver in the …
Peroxisome proliferator-activated receptor agonists and antagonists: a patent review (2014-present).
Takada I, Makishima M. Takada I, et al. Expert Opin Ther Pat. 2020 Jan;30(1):1-13. doi: 10.1080/13543776.2020.1703952. Epub 2019 Dec 18. Expert Opin Ther Pat. 2020. PMID: 31825687 Review.
Many synthetic ligands for PPARs have been developed to expand their therapeutic applications.Areas covered: The authors searched recent patent activity regarding PPAR ligands. Novel PPARalpha agonists, PPARdelta agonists, PPARgamma agonists, PPARalpha/gamma …
Many synthetic ligands for PPARs have been developed to expand their therapeutic applications.Areas covered: The authors searched recent pat …
Impairment of PPARalpha and the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging.
Chung KW, Lee EK, Lee MK, Oh GT, Yu BP, Chung HY. Chung KW, et al. J Am Soc Nephrol. 2018 Apr;29(4):1223-1237. doi: 10.1681/ASN.2017070802. Epub 2018 Feb 12. J Am Soc Nephrol. 2018. PMID: 29440279 Free PMC article.
In this study, we investigated peroxisome proliferator-activated receptor alpha (PPARalpha) and the FAO pathway as regulators of age-associated renal fibrosis. ...In particular, decreased PPARalpha protein expression associated with increased expression of …
In this study, we investigated peroxisome proliferator-activated receptor alpha (PPARalpha) and the FAO pathway as regulators …
PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease. Part I: PPAR-alpha.
Han L, Shen WJ, Bittner S, Kraemer FB, Azhar S. Han L, et al. Future Cardiol. 2017 May;13(3):259-278. doi: 10.2217/fca-2016-0059. Epub 2017 Jun 5. Future Cardiol. 2017. PMID: 28581332 Free PMC article. Review.
This article provides a comprehensive review about the molecular and metabolic actions of PPAR-alpha. It describes its structural features, ligand specificity, gene transcription mechanisms, functional characteristics and target genes. In addition, recent progress w …
This article provides a comprehensive review about the molecular and metabolic actions of PPAR-alpha. It describes its structu …
Gene Expression Profiles Induced by a Novel Selective Peroxisome Proliferator-Activated Receptor alpha Modulator (SPPARMalpha) Pemafibrate.
Sasaki Y, Raza-Iqbal S, Tanaka T, Murakami K, Anai M, Osawa T, Matsumura Y, Sakai J, Kodama T. Sasaki Y, et al. Int J Mol Sci. 2019 Nov 13;20(22):5682. doi: 10.3390/ijms20225682. Int J Mol Sci. 2019. PMID: 31766193 Free PMC article. Review.
Pemafibrate is the first clinically-available selective peroxisome proliferator-activated receptor alpha modulator (SPPARMalpha) that has been shown to effectively improve hypertriglyceridemia and low high-density lipoprotein cholesterol (HDL-C) levels. Global gene express …
Pemafibrate is the first clinically-available selective peroxisome proliferator-activated receptor alpha modulator (SPPARMalpha) that …
Fenofibrate induces PPARalpha and BMP2 expression to stimulate osteoblast differentiation.
Kim YH, Jang WG, Oh SH, Kim JW, Lee MN, Song JH, Yang JW, Zang Y, Koh JT. Kim YH, et al. Biochem Biophys Res Commun. 2019 Dec 3;520(2):459-465. doi: 10.1016/j.bbrc.2019.10.048. Epub 2019 Oct 10. Biochem Biophys Res Commun. 2019. PMID: 31607484 Free article.
The peroxisome proliferator-activated receptor (PPAR)-alpha agonist fenofibrate is used as a lipid-lowering agent to reduce cholesterol and triglyceride in blood. ...The chromatin immunoprecipitation assay demonstrated that fenofibrate increased BMP2 expression by i …
The peroxisome proliferator-activated receptor (PPAR)-alpha agonist fenofibrate is used as a lipid-lowering agent to reduce ch …
Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer's Disease via PPARalpha.
Chandra S, Jana M, Pahan K. Chandra S, et al. J Neurosci. 2018 Jul 25;38(30):6682-6699. doi: 10.1523/JNEUROSCI.0054-18.2018. Epub 2018 Jul 2. J Neurosci. 2018. PMID: 29967008 Free PMC article.
Interestingly, aspirin induced the activation of peroxisome proliferator-activated receptor alpha (PPARalpha) and stimulated the transcription of Tfeb via PPARalpha. ...Aspirin, one of the most widely used medications in the world, activates peroxisome prolif …
Interestingly, aspirin induced the activation of peroxisome proliferator-activated receptor alpha (PPARalpha) and stimulated t …
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