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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 2
1995 4
1996 12
1997 15
1998 25
1999 36
2000 54
2001 69
2002 108
2003 115
2004 149
2005 207
2006 201
2007 246
2008 258
2009 231
2010 214
2011 211
2012 224
2013 226
2014 186
2015 193
2016 189
2017 162
2018 179
2019 163
2020 135
2021 1
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3,379 results
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Page 1
PPARbeta/delta: Linking Metabolism to Regeneration.
Magadum A, Engel FB. Magadum A, et al. Int J Mol Sci. 2018 Jul 10;19(7):2013. doi: 10.3390/ijms19072013. Int J Mol Sci. 2018. PMID: 29996502 Free PMC article. Review.
Notably, many of these processes are associated with enhanced glycolysis. Therefore, peroxisome proliferator-activated receptor (PPAR) beta/delta-which is known to be involved for example in lipid catabolism, glucose homeostasis, inflammation, survival, proliferatio …
Notably, many of these processes are associated with enhanced glycolysis. Therefore, peroxisome proliferator-activated receptor (PPAR
Functional Regulation of PPARs through Post-Translational Modifications.
Brunmeir R, Xu F. Brunmeir R, et al. Int J Mol Sci. 2018 Jun 12;19(6):1738. doi: 10.3390/ijms19061738. Int J Mol Sci. 2018. PMID: 29895749 Free PMC article. Review.
The addition of these PTMs has a wide spectrum of consequences on protein stability, transactivation function, and co-factor interaction. Moreover, certain PTMs in PPAR proteins have been associated with the status of metabolic diseases. In this review, we summarize the PT …
The addition of these PTMs has a wide spectrum of consequences on protein stability, transactivation function, and co-factor interaction. Mo …
PPARdelta Promotes Running Endurance by Preserving Glucose.
Fan W, Waizenegger W, Lin CS, Sorrentino V, He MX, Wall CE, Li H, Liddle C, Yu RT, Atkins AR, Auwerx J, Downes M, Evans RM. Fan W, et al. Cell Metab. 2017 May 2;25(5):1186-1193.e4. doi: 10.1016/j.cmet.2017.04.006. Cell Metab. 2017. PMID: 28467934 Free PMC article.
Here we show that this key metabolic adaptation is both dependent on muscle PPARdelta and stimulated by PPARdelta ligand. Furthermore, we find that muscle PPARdelta expression positively correlates with endurance performance in BXD mouse reference populations …
Here we show that this key metabolic adaptation is both dependent on muscle PPARdelta and stimulated by PPARdelta ligand. Furt …
PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease. Part II: PPAR-beta/delta and PPAR-gamma.
Han L, Shen WJ, Bittner S, Kraemer FB, Azhar S. Han L, et al. Future Cardiol. 2017 May;13(3):279-296. doi: 10.2217/fca-2017-0019. Epub 2017 Jun 5. Future Cardiol. 2017. PMID: 28581362 Free PMC article. Review.
The PPARs are a subfamily of three ligand-inducible transcription factors, which belong to the superfamily of nuclear hormone receptors. In mammals, the PPAR subfamily consists of three members: PPAR-alpha, PPAR-beta/delta and PPAR-gamma. ...The …
The PPARs are a subfamily of three ligand-inducible transcription factors, which belong to the superfamily of nuclear hormone receptors. In …
PPARdelta agonist enhances colitis-associated colorectal cancer.
Zhou D, Jin J, Liu Q, Shi J, Hou Y. Zhou D, et al. Eur J Pharmacol. 2019 Jan 5;842:248-254. doi: 10.1016/j.ejphar.2018.10.050. Epub 2018 Nov 2. Eur J Pharmacol. 2019. PMID: 30391747
As a nuclear receptor, peroxisome proliferator-activated receptor-delta (PPARdelta) plays a critical role in regulating inflammation and cancer, while it is still unclear the mechanism of PPARdelta agonist GW501516 on colitis-associated colorectal cancer. Her …
As a nuclear receptor, peroxisome proliferator-activated receptor-delta (PPARdelta) plays a critical role in regulating inflam …
Elafibranor: a potential drug for the treatment of nonalcoholic steatohepatitis (NASH).
Westerouen Van Meeteren MJ, Drenth JPH, Tjwa ETTL. Westerouen Van Meeteren MJ, et al. Expert Opin Investig Drugs. 2020 Feb;29(2):117-123. doi: 10.1080/13543784.2020.1668375. Epub 2019 Sep 25. Expert Opin Investig Drugs. 2020. PMID: 31523999 Review.
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that regulate lipid and insulin metabolism, two key components in pathophysiology of NAFLD and NASH. Elafibranor acts as an agonist of PPAR-alpha and PPAR-delta and is currently under d …
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that regulate lipid and insulin metabolism, two key components in …
The Role of PPAR-delta in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor.
Liu Y, Colby JK, Zuo X, Jaoude J, Wei D, Shureiqi I. Liu Y, et al. Int J Mol Sci. 2018 Oct 26;19(11):3339. doi: 10.3390/ijms19113339. Int J Mol Sci. 2018. PMID: 30373124 Free PMC article. Review.
Peroxisome proliferator-activated receptor-delta (PPAR-delta), one of three members of the PPAR group in the nuclear receptor superfamily, is a ligand-activated transcription factor. ...This review discusses the complex relationship between PPAR
Peroxisome proliferator-activated receptor-delta (PPAR-delta), one of three members of the PPAR group in the nuc …
Peroxisome proliferator-activated receptor agonists and antagonists: a patent review (2014-present).
Takada I, Makishima M. Takada I, et al. Expert Opin Ther Pat. 2020 Jan;30(1):1-13. doi: 10.1080/13543776.2020.1703952. Epub 2019 Dec 18. Expert Opin Ther Pat. 2020. PMID: 31825687 Review.
PPARalpha agonists (fibrates) and PPARgamma agonists (thiazolidinediones) are used for the treatment of hypertriglyceridemia and type 2 diabetes, respectively. PPARdelta activation enhances mitochondrial and energy metabolism but PPARdelta-acting drugs are not yet a …
PPARalpha agonists (fibrates) and PPARgamma agonists (thiazolidinediones) are used for the treatment of hypertriglyceridemia and type 2 diab …
PPARdelta Mediates the Effect of Dietary Fat in Promoting Colorectal Cancer Metastasis.
Wang D, Fu L, Wei J, Xiong Y, DuBois RN. Wang D, et al. Cancer Res. 2019 Sep 1;79(17):4480-4490. doi: 10.1158/0008-5472.CAN-19-0384. Epub 2019 Jun 25. Cancer Res. 2019. PMID: 31239272 Free PMC article.
The nuclear hormone receptor peroxisome proliferator-activated receptor delta (PPARdelta) is a ligand-dependent transcription factor involved in fatty acid metabolism, obesity, wound healing, inflammation, and cancer. Although PPARdelta has been shown to prom …
The nuclear hormone receptor peroxisome proliferator-activated receptor delta (PPARdelta) is a ligand-dependent transcription …
A PML-PPAR-delta pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.
Ito K, Carracedo A, Weiss D, Arai F, Ala U, Avigan DE, Schafer ZT, Evans RM, Suda T, Lee CH, Pandolfi PP. Ito K, et al. Nat Med. 2012 Sep;18(9):1350-8. doi: 10.1038/nm.2882. Nat Med. 2012. PMID: 22902876 Free PMC article.
We have found that loss of PPAR-delta or inhibition of mitochondrial FAO induces loss of HSC maintenance, whereas treatment with PPAR-delta agonists improved HSC maintenance. PML exerts its essential role in HSC maintenance through regulation of PPA
We have found that loss of PPAR-delta or inhibition of mitochondrial FAO induces loss of HSC maintenance, whereas treatment wi …
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