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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1961 1
1969 2
1971 1
1973 2
1974 1
1975 5
1976 13
1977 14
1978 26
1979 43
1980 64
1981 62
1982 78
1983 120
1984 96
1985 137
1986 107
1987 116
1988 147
1989 167
1990 179
1991 186
1992 170
1993 154
1994 129
1995 109
1996 124
1997 110
1998 90
1999 63
2000 74
2001 80
2002 77
2003 89
2004 75
2005 85
2006 94
2007 77
2008 77
2009 72
2010 86
2011 65
2012 78
2013 68
2014 81
2015 86
2016 80
2017 71
2018 55
2019 56
2020 48
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3,941 results
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Page 1
Epigenetic Silencing of miRNA-338-5p and miRNA-421 Drives SPINK1-Positive Prostate Cancer.
Bhatia V, Yadav A, Tiwari R, Nigam S, Goel S, Carskadon S, Gupta N, Goel A, Palanisamy N, Ateeq B. Bhatia V, et al. Clin Cancer Res. 2019 May 1;25(9):2755-2768. doi: 10.1158/1078-0432.CCR-18-3230. Epub 2018 Dec 26. Clin Cancer Res. 2019. PMID: 30587549 Free PMC article.
PURPOSE: Serine peptidase inhibitor, Kazal type-1 (SPINK1) overexpression defines the second most recurrent and aggressive prostate cancer subtype. However, the underlying molecular mechanism and pathobiology of SPINK1 in prostate cancer remains largel …
PURPOSE: Serine peptidase inhibitor, Kazal type-1 (SPINK1) overexpression defines the second most recurrent and aggress …
Emerging Roles of SPINK1 in Cancer.
Räsänen K, Itkonen O, Koistinen H, Stenman UH. Räsänen K, et al. Clin Chem. 2016 Mar;62(3):449-57. doi: 10.1373/clinchem.2015.241513. Epub 2015 Dec 11. Clin Chem. 2016. PMID: 26656134 Review.
It had earlier been isolated from the pancreas and was hence called pancreatic secretory trypsin inhibitor (PSTI). It belongs to a family of protease inhibitors presently called serine peptidase inhibitor Kazal type (SPINK). ...However, b …
It had earlier been isolated from the pancreas and was hence called pancreatic secretory trypsin inhibitor (PSTI
An immunocapture-LC-MS-based assay for serum SPINK1 allows simultaneous quantification and detection of SPINK1 variants.
Ravela S, Valmu L, Domanskyy M, Koistinen H, Kylänpää L, Lindström O, Stenman J, Hämäläinen E, Stenman UH, Itkonen O. Ravela S, et al. Anal Bioanal Chem. 2018 Feb;410(6):1679-1688. doi: 10.1007/s00216-017-0803-y. Epub 2018 Jan 9. Anal Bioanal Chem. 2018. PMID: 29318362
Pancreatic secretory trypsin inhibitor Kazal type 1 (SPINK1) is a 6420 Da peptide produced by the pancreas, but also by several other tissues and many tumors. ...Detection of such variants are therefore of clinical utility. So far SPINK1
Pancreatic secretory trypsin inhibitor Kazal type 1 (SPINK1) is a 6420 Da peptide produced by the pancrea
Natural history of SPINK1 germline mutation related-pancreatitis.
Muller N, Sarantitis I, Rouanet M, de Mestier L, Halloran C, Greenhalf W, Férec C, Masson E, Ruszniewski P, Lévy P, Neoptolemos J, Buscail L, Rebours V. Muller N, et al. EBioMedicine. 2019 Oct;48:581-591. doi: 10.1016/j.ebiom.2019.09.032. Epub 2019 Oct 15. EBioMedicine. 2019. PMID: 31628023 Free PMC article.
METHODS: All SPINK1 mutation carriers with pancreatic symptoms from two French and one English centers were included. ...Seven patients (3.3%) developed pancreatic cancer in the SPINK1 group (versus 3 (0.99%), p = 0.1), at a median age of 60 vs 66 year …
METHODS: All SPINK1 mutation carriers with pancreatic symptoms from two French and one English centers were included. ...Seven …
Toward a clinical diagnostic pipeline for SPINK1 intronic variants.
Tang XY, Lin JH, Zou WB, Masson E, Boulling A, Deng SJ, Cooper DN, Liao Z, Férec C, Li ZS, Chen JM. Tang XY, et al. Hum Genomics. 2019 Feb 12;13(1):8. doi: 10.1186/s40246-019-0193-7. Hum Genomics. 2019. PMID: 30755276 Free PMC article.
However, until now, a clinical diagnostic pipeline specifically designed to classify SPINK1 intronic variants accurately and efficiently has been lacking. ...CONCLUSIONS: We demonstrated the accuracy and efficiency of in silico prediction in combination with the cell cultu …
However, until now, a clinical diagnostic pipeline specifically designed to classify SPINK1 intronic variants accurately and efficien …
Genetic background of pancreatitis.
Hirota M, Ohmuraya M, Baba H. Hirota M, et al. Postgrad Med J. 2006 Dec;82(974):775-8. doi: 10.1136/pgmj.2006.050591. Postgrad Med J. 2006. PMID: 17148697 Free PMC article. Review.
Trypsin activity is properly suppressed by pancreatic secretory trypsin inhibitor (PSTI), which is also known as serine protease inhibitor Kazal type 1 (SPINK1), thereby preventing damage to pancreatic acinar cells as
Trypsin activity is properly suppressed by pancreatic secretory trypsin inhibitor (PSTI), which is also k
Hepatitis B Virus X Protein-Induced Serine Protease Inhibitor Kazal Type 1 Is Associated with the Progression of HBV-Related Diseases.
Zhu C, Han H, Li J, Xu L, Liu F, Wu K, Liu X. Zhu C, et al. Biomed Res Int. 2019 May 22;2019:9321494. doi: 10.1155/2019/9321494. eCollection 2019. Biomed Res Int. 2019. PMID: 31240230 Free PMC article.
OBJECTIVE: Hepatitis B virus (HBV) causes inflammation of the liver and is the leading cause of both liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Serine protease inhibitor Kazal type 1 (SPINK1) is an acute-phase response protein that is overexpres …
OBJECTIVE: Hepatitis B virus (HBV) causes inflammation of the liver and is the leading cause of both liver cirrhosis (LC) and hepatocellular …
Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance.
Chen F, Long Q, Fu D, Zhu D, Ji Y, Han L, Zhang B, Xu Q, Liu B, Li Y, Wu S, Yang C, Qian M, Xu J, Liu S, Cao L, Chin YE, Lam EW, Coppé JP, Sun Y. Chen F, et al. Nat Commun. 2018 Oct 17;9(1):4315. doi: 10.1038/s41467-018-06860-4. Nat Commun. 2018. PMID: 30333494 Free PMC article.
Chemotherapy and radiation not only trigger cancer cell apoptosis but also damage stromal cells in the tumour microenvironment (TME), inducing a senescence-associated secretory phenotype (SASP) characterized by chronic secretion of diverse soluble factors. Here we report serine p …
Chemotherapy and radiation not only trigger cancer cell apoptosis but also damage stromal cells in the tumour microenvironment (TME), induci …
Meta-analysis of the impact of SPINK1 p.N34S gene variation in Caucasic patients with chronic pancreatitis. An update.
Di Leo M, Bianco M, Zuppardo RA, Guslandi M, Calabrese F, Mannucci A, Neri TM, Testoni PA, Leandro G, Cavestro GM. Di Leo M, et al. Dig Liver Dis. 2017 Aug;49(8):847-853. doi: 10.1016/j.dld.2017.04.023. Epub 2017 May 6. Dig Liver Dis. 2017. PMID: 28546062 Review.
BACKGROUND: SPINK1 p.N34S gene variation is one of the endogenous factors which seem to be associated with chronic pancreatitis (CP). ...After that, we performed two additional meta-analyses considering the incidence of SPINK1 p.N34S gene variation in alcoholic or i …
BACKGROUND: SPINK1 p.N34S gene variation is one of the endogenous factors which seem to be associated with chronic pancreatitis (CP). …
TATI as a biomarker.
Itkonen O, Stenman UH. Itkonen O, et al. Clin Chim Acta. 2014 Apr 20;431:260-9. doi: 10.1016/j.cca.2014.02.014. Epub 2014 Feb 26. Clin Chim Acta. 2014. PMID: 24583226 Review.
Tumor-associated trypsin inhibitor (TATI) [also called serine peptidase inhibitor Kazal type1, SPINK1 and, in the pancreas, pancreatic secretory trypsin inhibitor (PSTI)] inhibits trypsin and other serine prote …
Tumor-associated trypsin inhibitor (TATI) [also called serine peptidase inhibitor Kazal type1, SPINK1 and …
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