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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 2
1995 2
1996 1
1997 2
1998 2
1999 2
2001 4
2002 6
2003 5
2004 10
2005 6
2006 9
2007 7
2008 12
2009 18
2010 22
2011 22
2012 24
2013 34
2014 30
2015 27
2016 14
2017 19
2018 35
2019 46
2020 29
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342 results
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Page 1
The role of STAT3 in autophagy.
You L, Wang Z, Li H, Shou J, Jing Z, Xie J, Sui X, Pan H, Han W. You L, et al. Autophagy. 2015;11(5):729-39. doi: 10.1080/15548627.2015.1017192. Autophagy. 2015. PMID: 25951043 Free PMC article. Review.
PTPN2 regulates the generation of exhausted CD8(+) T cell subpopulations and restrains tumor immunity.
LaFleur MW, Nguyen TH, Coxe MA, Miller BC, Yates KB, Gillis JE, Sen DR, Gaudiano EF, Al Abosy R, Freeman GJ, Haining WN, Sharpe AH. LaFleur MW, et al. Nat Immunol. 2019 Oct;20(10):1335-1347. doi: 10.1038/s41590-019-0480-4. Epub 2019 Sep 16. Nat Immunol. 2019. PMID: 31527834 Free PMC article.
Here we establish the phosphatase PTPN2 as a new regulator of the differentiation of the terminally exhausted subpopulation that functions by attenuating type 1 interferon signaling. ...Likewise, Ptpn2 deletion in CD8(+) T cells enhanced Tim-3(+) anti-tumor response …
Here we establish the phosphatase PTPN2 as a new regulator of the differentiation of the terminally exhausted subpopulation that func …
Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC.
Grohmann M, Wiede F, Dodd GT, Gurzov EN, Ooi GJ, Butt T, Rasmiena AA, Kaur S, Gulati T, Goh PK, Treloar AE, Archer S, Brown WA, Muller M, Watt MJ, Ohara O, McLean CA, Tiganis T. Grohmann M, et al. Cell. 2018 Nov 15;175(5):1289-1306.e20. doi: 10.1016/j.cell.2018.09.053. Epub 2018 Oct 25. Cell. 2018. PMID: 30454647 Free PMC article.
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia.
Liu Y, Easton J, Shao Y, Maciaszek J, Wang Z, Wilkinson MR, McCastlain K, Edmonson M, Pounds SB, Shi L, Zhou X, Ma X, Sioson E, Li Y, Rusch M, Gupta P, Pei D, Cheng C, Smith MA, Auvil JG, Gerhard DS, Relling MV, Winick NJ, Carroll AJ, Heerema NA, Raetz E, Devidas M, Willman CL, Harvey RC, Carroll WL, Dunsmore KP, Winter SS, Wood BL, Sorrentino BP, Downing JR, Loh ML, Hunger SP, Zhang J, Mullighan CG. Liu Y, et al. Nat Genet. 2017 Aug;49(8):1211-1218. doi: 10.1038/ng.3909. Epub 2017 Jul 3. Nat Genet. 2017. PMID: 28671688 Free PMC article.
For example, NRAS/FLT3 mutations were associated with immature T-ALL, JAK3/STAT5B mutations in HOXA1 deregulated ALL, PTPN2 mutations in TLX1 deregulated T-ALL, and PIK3R1/PTEN mutations in TAL1 deregulated ALL, which suggests that different signaling pathways have distinc …
For example, NRAS/FLT3 mutations were associated with immature T-ALL, JAK3/STAT5B mutations in HOXA1 deregulated ALL, PTPN2 mutations …
Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.
Svensson MN, Doody KM, Schmiedel BJ, Bhattacharyya S, Panwar B, Wiede F, Yang S, Santelli E, Wu DJ, Sacchetti C, Gujar R, Seumois G, Kiosses WB, Aubry I, Kim G, Mydel P, Sakaguchi S, Kronenberg M, Tiganis T, Tremblay ML, Ay F, Vijayanand P, Bottini N. Svensson MN, et al. J Clin Invest. 2019 Mar 1;129(3):1193-1210. doi: 10.1172/JCI123267. Epub 2019 Feb 11. J Clin Invest. 2019. PMID: 30620725 Free PMC article.
PTPN2 inhibits signaling through the T cell and cytokine receptors, and loss of PTPN2 promotes T cell expansion and CD4- and CD8-driven autoimmunity. ...We conclude that PTPN2 promotes FoxP3 stability in mouse RORγt+ Tregs and that loss of function of PTPN
PTPN2 inhibits signaling through the T cell and cytokine receptors, and loss of PTPN2 promotes T cell expansion and CD4- and C
In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target.
Manguso RT, Pope HW, Zimmer MD, Brown FD, Yates KB, Miller BC, Collins NB, Bi K, LaFleur MW, Juneja VR, Weiss SA, Lo J, Fisher DE, Miao D, Van Allen E, Root DE, Sharpe AH, Doench JG, Haining WN. Manguso RT, et al. Nature. 2017 Jul 27;547(7664):413-418. doi: 10.1038/nature23270. Epub 2017 Jul 19. Nature. 2017. PMID: 28723893 Free PMC article.
In addition, deletion of the protein tyrosine phosphatase PTPN2 in tumour cells increased the efficacy of immunotherapy by enhancing interferon-γ-mediated effects on antigen presentation and growth suppression. ...
In addition, deletion of the protein tyrosine phosphatase PTPN2 in tumour cells increased the efficacy of immunotherapy by enhancing …
PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer.
Spalinger MR, Manzini R, Hering L, Riggs JB, Gottier C, Lang S, Atrott K, Fettelschoss A, Olomski F, Kündig TM, Fried M, McCole DF, Rogler G, Scharl M. Spalinger MR, et al. Cell Rep. 2018 Feb 13;22(7):1835-1848. doi: 10.1016/j.celrep.2018.01.052. Cell Rep. 2018. PMID: 29444435 Free PMC article.
The anti-inflammatory role of PTPN2 is highlighted by the fact that PTPN2-deficient mice die a few weeks after birth because of systemic inflammation and severe colitis. ...Here, we demonstrate that myeloid cell-specific deletion of PTPN2 in mice (PTPN2
The anti-inflammatory role of PTPN2 is highlighted by the fact that PTPN2-deficient mice die a few weeks after birth because o …
The effects of PTPN2 loss on cell signalling and clinical outcome in relation to breast cancer subtype.
Veenstra C, Karlsson E, Mirwani SM, Nordenskjöld B, Fornander T, Pérez-Tenorio G, Stål O. Veenstra C, et al. J Cancer Res Clin Oncol. 2019 Jul;145(7):1845-1856. doi: 10.1007/s00432-019-02918-y. Epub 2019 Apr 25. J Cancer Res Clin Oncol. 2019. PMID: 31025094 Free PMC article.
As PTPN2 is not frequently studied in breast cancer, we aimed to explore the role of PTPN2 and the effects of its loss in breast cancer. ...PTPN2 was knocked down in three cell lines, representing different breast cancer subtypes, with siRNA transfection. Sev …
As PTPN2 is not frequently studied in breast cancer, we aimed to explore the role of PTPN2 and the effects of its loss in brea …
PTPN2 improved renal injury and fibrosis by suppressing STAT-induced inflammation in early diabetic nephropathy.
Li Y, Zhou H, Li Y, Han L, Song M, Chen F, Shang G, Wang D, Wang Z, Zhang W, Zhong M. Li Y, et al. J Cell Mol Med. 2019 Jun;23(6):4179-4195. doi: 10.1111/jcmm.14304. Epub 2019 Apr 6. J Cell Mol Med. 2019. PMID: 30955247 Free PMC article.
We found that mice treated with PTPN2 displayed reduced serum creatinine, serum BUN and proteinuria. PTPN2 gene therapy markedly attenuated metabolic disorders and hyperglycaemia. ...Furthermore, PTPN2 overexpression inhibited the high-glucose induced phospho …
We found that mice treated with PTPN2 displayed reduced serum creatinine, serum BUN and proteinuria. PTPN2 gene therapy marked …
25-Hydroxyvitamin D(3) -enhanced PTPN2 positively regulates periodontal inflammation through the JAK/STAT pathway in human oral keratinocytes and a mouse model of type 2 diabetes mellitus.
Zhang P, Zhang W, Zhang D, Wang M, Aprecio R, Ji N, Mohamed O, Li Y, Ding Y, Wang Q. Zhang P, et al. J Periodontal Res. 2018 Jun;53(3):467-477. doi: 10.1111/jre.12535. Epub 2018 Mar 8. J Periodontal Res. 2018. PMID: 29516520
The aim of this study was to investigate the regulation of PTPN2 in periodontal inflammation in diabetes mellitus-associated periodontitis. ...The effect of PTPN2 on human OKF6-TERT2 oral keratinocytes was examined through the knockout of PTPN2 using the CRIS …
The aim of this study was to investigate the regulation of PTPN2 in periodontal inflammation in diabetes mellitus-associated periodon …
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