Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 1
2001 1
2002 2
2003 1
2004 8
2005 61
2006 67
2007 79
2008 89
2009 109
2010 91
2011 92
2012 97
2013 88
2014 87
2015 87
2016 78
2017 73
2018 60
2019 59
2020 31
Text availability
Article attribute
Article type
Publication date

Search Results

1,096 results
Results by year
Filters applied: . Clear all
Page 1
Regulation of autoimmune and anti-tumour T-cell responses by PTPN22.
Brownlie RJ, Zamoyska R, Salmond RJ. Brownlie RJ, et al. Immunology. 2018 Jul;154(3):377-382. doi: 10.1111/imm.12919. Epub 2018 Apr 16. Immunology. 2018. PMID: 29512901 Free PMC article. Review.
PTPN22 regulates the activity and effector functions of multiple important immune cell types, including lymphocytes, granulocytes and myeloid cells. In this review, we describe the role of PTPN22 in regulating T-cell activation and effector responses. We discuss pro
PTPN22 regulates the activity and effector functions of multiple important immune cell types, including lymphocytes, granulocytes and
The potential of PTPN22 as a therapeutic target for rheumatoid arthritis.
Carmona FD, Martín J. Carmona FD, et al. Expert Opin Ther Targets. 2018 Oct;22(10):879-891. doi: 10.1080/14728222.2018.1526924. Expert Opin Ther Targets. 2018. PMID: 30251905 Review.
A missense PTPN22 allele (R620W) affecting the protein-protein interaction of LYP with other relevant players was described as the functional variant of the association. ...As cumulating evidences suggest that PTPN22 R620W is a gain-of-function variant, a growing in …
A missense PTPN22 allele (R620W) affecting the protein-protein interaction of LYP with other relevant players was described as the fu …
Association of PTPN22 1858C/T Polymorphism with Autoimmune Diseases: A Systematic Review and Bayesian Approach.
Tizaoui K, Kim SH, Jeong GH, Kronbichler A, Lee KS, Lee KH, Shin JI. Tizaoui K, et al. J Clin Med. 2019 Mar 12;8(3):347. doi: 10.3390/jcm8030347. J Clin Med. 2019. PMID: 30871019 Free PMC article.
The 1858T allele in the protein tyrosine phosphatase non-receptor type 22 (PTPN22) locus shows one of the strongest and most consistent genetic associations with autoimmune diseases. We synthesized all meta-analyses reporting a genetic association of the PTPN22 1858 …
The 1858T allele in the protein tyrosine phosphatase non-receptor type 22 (PTPN22) locus shows one of the strongest and most consiste …
Regulation of B cell homeostasis by Ptpn22 contributes to type 1 diabetes in NOD mice.
Shi X, Shao F, Li Z, Kang L, Liu J, Kissler S, Zhou Z, Jia L, Zheng P. Shi X, et al. Endocrine. 2020 Mar;67(3):535-543. doi: 10.1007/s12020-019-02120-7. Epub 2019 Nov 15. Endocrine. 2020. PMID: 31732921
PURPOSE: A coding variant in PTPN22 (C1858T) is one of the most important genetic risk factors in type 1 diabetes (T1D). The role of the PTPN22 risk allele in B cells is still incompletely understood and has not been investigated directly in T1D. ...CONCLUSIONS: Our …
PURPOSE: A coding variant in PTPN22 (C1858T) is one of the most important genetic risk factors in type 1 diabetes (T1D). The role of …
The Contribution of PTPN22 to Rheumatic Disease.
Mustelin T, Bottini N, Stanford SM. Mustelin T, et al. Arthritis Rheumatol. 2019 Apr;71(4):486-495. doi: 10.1002/art.40790. Epub 2019 Mar 2. Arthritis Rheumatol. 2019. PMID: 30507064 Free PMC article. Review.
Among the many genes that increase the risk of autoimmune conditions, the risk allele encoding the W620 variant of protein tyrosine phosphatase N22 (PTPN22) is shared between multiple rheumatic diseases, suggesting that it plays a fundamental role in the development of imm …
Among the many genes that increase the risk of autoimmune conditions, the risk allele encoding the W620 variant of protein tyrosine phosphat …
The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens.
Clarke F, Purvis HA, Sanchez-Blanco C, Gutiérrez-Martinez E, Cornish GH, Zamoyska R, Guermonprez P, Cope AP. Clarke F, et al. Sci Rep. 2018 Aug 23;8(1):12692. doi: 10.1038/s41598-018-31179-x. Sci Rep. 2018. PMID: 30139951 Free PMC article.
A C1858T single nucleotide polymorphism within PTPN22 (which encodes PTPN22(R620W)) is associated with an enhanced susceptibility to multiple autoimmune diseases including type 1 diabetes and rheumatoid arthritis. ...These findings highlight PTPN22 as a regul …
A C1858T single nucleotide polymorphism within PTPN22 (which encodes PTPN22(R620W)) is associated with an enhanced susceptibil …
Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2.
Bray C, Wright D, Haupt S, Thomas S, Stauss H, Zamoyska R. Bray C, et al. Front Immunol. 2018 Nov 12;9:2595. doi: 10.3389/fimmu.2018.02595. eCollection 2018. Front Immunol. 2018. PMID: 30483260 Free PMC article.
By comparing isogenic human T cells which express or lack PTPN22, we showed that PTPN22 KO T cells displayed enhanced expression of IL-2 and CD69 upon stimulation with cognate antigen. PTPN22 KO cells also showed increased Erk phosphorylation upon stimulation …
By comparing isogenic human T cells which express or lack PTPN22, we showed that PTPN22 KO T cells displayed enhanced expressi …
Experimental colitis in IL-10-deficient mice ameliorates in the absence of PTPN22.
Jofra T, Galvani G, Cosorich I, De Giorgi L, Annoni A, Vecchione A, Sorini C, Falcone M, Fousteri G. Jofra T, et al. Clin Exp Immunol. 2019 Sep;197(3):263-275. doi: 10.1111/cei.13339. Epub 2019 Jul 10. Clin Exp Immunol. 2019. PMID: 31194881 Free PMC article.
Here, we examined the role of PTPN22 in intestinal inflammation of IL-10-deficient (IL-10(-/-) ) mice. We crossed IL-10(-/-) mice with PTPN22(-/-) mice to generate PTPN22(-/-) IL-10(-/-) double knock-out mice and induced colitis with dextran sodium sulphate ( …
Here, we examined the role of PTPN22 in intestinal inflammation of IL-10-deficient (IL-10(-/-) ) mice. We crossed IL-10(-/-) mice wit …
Infections, genetic and environmental factors in pathogenesis of autoimmune thyroid diseases.
Shukla SK, Singh G, Ahmad S, Pant P. Shukla SK, et al. Microb Pathog. 2018 Mar;116:279-288. doi: 10.1016/j.micpath.2018.01.004. Epub 2018 Jan 8. Microb Pathog. 2018. PMID: 29325864 Review.
CD40, PTPN22 and thyroid-specific genes are immunomodulating genes for the TSH receptor and thyroglobulin. CD40 used to be associated with Graves's disease as positional candidate on the basis of Graves' disease linkage study connecting with 20q11 genome chromosomal region …
CD40, PTPN22 and thyroid-specific genes are immunomodulating genes for the TSH receptor and thyroglobulin. CD40 used to be associated …
PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner.
Spalinger MR, Lang S, Gottier C, Dai X, Rawlings DJ, Chan AC, Rogler G, Scharl M. Spalinger MR, et al. Autophagy. 2017 Sep 2;13(9):1590-1601. doi: 10.1080/15548627.2017.1341453. Epub 2017 Aug 8. Autophagy. 2017. PMID: 28786745 Free PMC article.
Here, we demonstrate that loss of macroautophagy/autophagy abrogates the inhibitory effect on NLRP3 activation observed upon loss of PTPN22. ...Given its role in inflammatory disorders, PTPN22 might be an attractive therapeutic target, and understanding the cellular …
Here, we demonstrate that loss of macroautophagy/autophagy abrogates the inhibitory effect on NLRP3 activation observed upon loss of PTPN
1,096 results
Jump to page
Feedback