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Year Number of Results
1961 1
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1974 1
1975 8
1976 3
1977 7
1978 8
1979 5
1980 11
1981 17
1982 13
1983 28
1984 32
1985 60
1986 70
1987 100
1988 124
1989 206
1990 254
1991 298
1992 404
1993 418
1994 456
1995 448
1996 424
1997 445
1998 433
1999 457
2000 489
2001 513
2002 529
2003 631
2004 590
2005 654
2006 682
2007 727
2008 786
2009 772
2010 839
2011 899
2012 953
2013 964
2014 965
2015 1004
2016 949
2017 928
2018 907
2019 848
2020 882
2021 53
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19,562 results
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Page 1
CD45 in human physiology and clinical medicine.
Rheinländer A, Schraven B, Bommhardt U. Rheinländer A, et al. Immunol Lett. 2018 Apr;196:22-32. doi: 10.1016/j.imlet.2018.01.009. Epub 2018 Jan 31. Immunol Lett. 2018. PMID: 29366662 Review.
CD45 deficiency results in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency. It also plays a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections. The knowledge collected on CD45 …
CD45 deficiency results in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency. It also plays a signific …
CD45: a critical regulator of signaling thresholds in immune cells.
Hermiston ML, Xu Z, Weiss A. Hermiston ML, et al. Annu Rev Immunol. 2003;21:107-37. doi: 10.1146/annurev.immunol.21.120601.140946. Epub 2001 Dec 19. Annu Rev Immunol. 2003. PMID: 12414720 Review.
Studies of CD45 mutant cell lines, CD45-deficient mice, and CD45-deficient humans initially demonstrated the essential role of CD45 in antigen receptor signal transduction and lymphocyte development. It is now known that CD45 also modulates sign …
Studies of CD45 mutant cell lines, CD45-deficient mice, and CD45-deficient humans initially demonstrated the essential …
The role of CD45 and CD45-associated molecules in T cell activation.
Altin JG, Sloan EK. Altin JG, et al. Immunol Cell Biol. 1997 Oct;75(5):430-45. doi: 10.1038/icb.1997.68. Immunol Cell Biol. 1997. PMID: 9429890 Review.
CD45 (lymphocyte common antigen) is a receptor-linked protein tyrosine phosphatase that is expressed on all leucocytes, and which plays a crucial role in the function of these cells. ...These CD45-associated molecules may play an important role in regulating …
CD45 (lymphocyte common antigen) is a receptor-linked protein tyrosine phosphatase that is expressed on all leucocytes, and wh …
Initiation of T cell signaling by CD45 segregation at 'close contacts'.
Chang VT, Fernandes RA, Ganzinger KA, Lee SF, Siebold C, McColl J, Jönsson P, Palayret M, Harlos K, Coles CH, Jones EY, Lui Y, Huang E, Gilbert RJC, Klenerman D, Aricescu AR, Davis SJ. Chang VT, et al. Nat Immunol. 2016 May;17(5):574-582. doi: 10.1038/ni.3392. Epub 2016 Mar 21. Nat Immunol. 2016. PMID: 26998761 Free PMC article.
Using structural and biophysical analysis, we show that the extracellular region of CD45 is rigid and extends beyond the distance spanned by TCR-ligand complexes, implying that sites of TCR-ligand engagement would sterically exclude CD45. We also show that the forma …
Using structural and biophysical analysis, we show that the extracellular region of CD45 is rigid and extends beyond the distance spa …
Altered CD45 expression and disease.
Tchilian EZ, Beverley PC. Tchilian EZ, et al. Trends Immunol. 2006 Mar;27(3):146-53. doi: 10.1016/j.it.2006.01.001. Epub 2006 Jan 18. Trends Immunol. 2006. PMID: 16423560 Review.
CD45, the leucocyte common antigen, is a haemopoietic cell-specific tyrosine phosphatase. Many isoforms are generated by alternative splicing, but their function remains obscure. The extracellular domain of CD45 is highly polymorphic in all vertebrates. Impor …
CD45, the leucocyte common antigen, is a haemopoietic cell-specific tyrosine phosphatase. Many isoforms are generated by alter …
Size-Dependent Segregation Controls Macrophage Phagocytosis of Antibody-Opsonized Targets.
Bakalar MH, Joffe AM, Schmid EM, Son S, Podolski M, Fletcher DA. Bakalar MH, et al. Cell. 2018 Jun 28;174(1):131-142.e13. doi: 10.1016/j.cell.2018.05.059. Cell. 2018. PMID: 29958103 Free PMC article.
Here, we define an antigen height threshold that regulates phagocytosis of both engineered and cancer-specific antigens by macrophages. Using a reconstituted model of antibody-opsonized target cells, we find that phagocytosis is dramatically impaired for antigens th …
Here, we define an antigen height threshold that regulates phagocytosis of both engineered and cancer-specific antigens by macrophage …
CD45 antigen negativity in T-lineage ALL correlates with PTPRC mutation and sensitivity to a selective JAK inhibitor.
Raponi S, Gianfelici V, Chiaretti S, Peragine N, Brugnoletti F, De Propris MS, Marinelli M, Hulselmans G, Aerts S, Geerdens E, Cools J, Foà R, Guarini A. Raponi S, et al. Br J Haematol. 2015 Dec;171(5):884-7. doi: 10.1111/bjh.13448. Epub 2015 Apr 8. Br J Haematol. 2015. PMID: 25854815 No abstract available.
Clinical effects of CD45 on the prognosis of extramedullary myeloma relapse.
Oka S, Ono K, Nohgawa M. Oka S, et al. J Clin Pharm Ther. 2020 Feb;45(1):144-151. doi: 10.1111/jcpt.13045. Epub 2019 Sep 18. J Clin Pharm Ther. 2020. PMID: 31532009
RESULTS AND DISCUSSION: Extramedullary relapse was detected in 55 of 231 patients (23.8%). At the diagnosis of EMR, CD45, the leucocyte common antigen, was detected in 54.5% of cases. ...Moreover, high-risk cytogenetics was more frequently observed in CD45- t …
RESULTS AND DISCUSSION: Extramedullary relapse was detected in 55 of 231 patients (23.8%). At the diagnosis of EMR, CD45, the leucocy …
Viral interference with functions of the cellular receptor tyrosine phosphatase CD45.
Thiel N, Zischke J, Elbasani E, Kay-Fedorov P, Messerle M. Thiel N, et al. Viruses. 2015 Mar 23;7(3):1540-57. doi: 10.3390/v7031540. Viruses. 2015. PMID: 25807057 Free PMC article. Review.
The receptor tyrosine phosphatase CD45 is expressed on the surface of almost all cells of hematopoietic origin. ...Finally, we summarize the evidence that pathogens were the driving force for the evolution of CD45....
The receptor tyrosine phosphatase CD45 is expressed on the surface of almost all cells of hematopoietic origin. ...Finally, we summar …
[Expression of CD45 in newly diagnosed multiple myeloma and the relationship with prognosis].
Shi J, Zhu ZM, Sun K, Lei PC, Liu ZW, Guo JM, Yang J, Zang YZ, Zhang Y. Shi J, et al. Zhonghua Xue Ye Xue Za Zhi. 2019 Sep 14;40(9):744-749. doi: 10.3760/cma.j.issn.0253-2727.2019.09.006. Zhonghua Xue Ye Xue Za Zhi. 2019. PMID: 31648475 Free PMC article. Chinese.
Methods: This study retrospectively analyzed expression and distribution of CD45 in 130 cases of newly diagnosed MM, comparing clinical efficacy and prognosis in CD45(+)/CD45(-) groups. Results: 1The CD45(+) group was 33 cases (25.38%) , and CD45 …
Methods: This study retrospectively analyzed expression and distribution of CD45 in 130 cases of newly diagnosed MM, comparing clinic …
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