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Year Number of Results
2006 1
2007 1
2008 1
2009 2
2011 1
2014 1
2015 2
2016 2
2018 2
2020 0
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Novel and emerging therapies for cholestatic liver diseases.
Goldstein J, Levy C. Goldstein J, et al. Liver Int. 2018 Sep;38(9):1520-1535. doi: 10.1111/liv.13880. Epub 2018 Jun 14. Liver Int. 2018. PMID: 29758112 Review.
By altering or overwhelming these defence mechanisms, cholestatic diseases such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) can further progress to biliary cirrhosis, end-stage liver disease and death or liver transplantation …
By altering or overwhelming these defence mechanisms, cholestatic diseases such as primary biliary cholangitis (PBC) and primary s
Cholestatic Itch Management.
Mittal A. Mittal A. Curr Probl Dermatol. 2016;50:142-8. doi: 10.1159/000446057. Epub 2016 Aug 23. Curr Probl Dermatol. 2016. PMID: 27578083 Review.
Cholestatic itch is a feature of numerous hepatobiliary disorders such as primary biliary cirrhosis, primary sclerosing cholangitis, the inherited form of cholestasis, and intrahepatic cholestasis of pregnancy. ...Treatment options for patients with cholestatic itch …
Cholestatic itch is a feature of numerous hepatobiliary disorders such as primary biliary cirrhosis, primary sclerosing cholangiti
Bile Acid Synthesis: From Nature to the Chemical Modification and Synthesis and Their Applications as Drugs and Nutrients.
Šarenac TM, Mikov M. Šarenac TM, et al. Front Pharmacol. 2018 Sep 25;9:939. doi: 10.3389/fphar.2018.00939. eCollection 2018. Front Pharmacol. 2018. PMID: 30319399 Free PMC article. Review.
It has been found that BAs are also associated with other receptors such as the vitamin D receptor (VDR), from which the most significant ligand is calcitriol, as well as with pregnane X receptor (PXR) and potentially with the constitutive androstane receptor (CAR), whose …
It has been found that BAs are also associated with other receptors such as the vitamin D receptor (VDR), from which the most significant li …
The human gut sterolbiome: bile acid-microbiome endocrine aspects and therapeutics.
Ridlon JM, Bajaj JS. Ridlon JM, et al. Acta Pharm Sin B. 2015 Mar;5(2):99-105. doi: 10.1016/j.apsb.2015.01.006. Epub 2015 Feb 9. Acta Pharm Sin B. 2015. PMID: 26579434 Free PMC article. Review.
Medical treatment of primary sclerosing cholangitis: a role for novel bile acids and other (post-)transcriptional modulators?
Beuers U, Kullak-Ublick GA, Pusl T, Rauws ER, Rust C. Beuers U, et al. Clin Rev Allergy Immunol. 2009 Feb;36(1):52-61. doi: 10.1007/s12016-008-8085-y. Clin Rev Allergy Immunol. 2009. PMID: 18751930 Free article. Review.
Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic disease of the liver and bile ducts that is associated with inflammatory bowel disease, generally leads to end-stage liver disease, and is complicated by malignancies of the biliary tree and the larg …
Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic disease of the liver and bile ducts that is associated with …
Novel Aspects in the Management of Cholestatic Liver Diseases.
Chazouillères O. Chazouillères O. Dig Dis. 2016;34(4):340-6. doi: 10.1159/000444544. Epub 2016 May 11. Dig Dis. 2016. PMID: 27170387
Novel tools for monitoring primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) patients have been recently proposed. ...The most advanced clinical evaluation (PBC patients) relates to agonists for PPARα, FXR and GR/PXR most often in combi …
Novel tools for monitoring primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) patients have been recentl …
Nuclear receptors CAR and PXR; therapeutic targets for cholestatic liver disease.
Kakizaki S, Takizawa D, Tojima H, Horiguchi N, Yamazaki Y, Mori M. Kakizaki S, et al. Front Biosci (Landmark Ed). 2011 Jun 1;16:2988-3005. doi: 10.2741/3893. Front Biosci (Landmark Ed). 2011. PMID: 21622216 Review.
In addition to FXR, the nuclear receptors CAR and PXR function as sensors of toxic byproducts and regulator of BA homeostasis. ...Novel compounds targeting CAR and PXR with specific effects and fewer side effects will therefore be useful for the treatment of cholest …
In addition to FXR, the nuclear receptors CAR and PXR function as sensors of toxic byproducts and regulator of BA homeostasis. ...Nov …
Liver Expression of Sulphotransferase 2A1 Enzyme Is Impaired in Patients with Primary Sclerosing Cholangitis: Lack of the Response to Enhanced Expression of PXR.
Wunsch E, Klak M, Wasik U, Milkiewicz M, Blatkiewicz M, Urasinska E, Barbier O, Bielicki D, Bogdanos DP, Elias E, Milkiewicz P. Wunsch E, et al. J Immunol Res. 2015;2015:571353. doi: 10.1155/2015/571353. Epub 2015 Oct 4. J Immunol Res. 2015. PMID: 26504856 Free PMC article.
Transcription of SULT2A1 gene is induced by pregnane-X-receptor (PXR) and can be repressed by miR-378a-5p. We studied the PXR/SULT2A1 axis in chronic cholestatic conditions: primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). MATE …
Transcription of SULT2A1 gene is induced by pregnane-X-receptor (PXR) and can be repressed by miR-378a-5p. We studied the PXR/ …
Advances in pathogenesis and management of pruritus in cholestasis.
Kremer AE, Bolier R, van Dijk R, Oude Elferink RP, Beuers U. Kremer AE, et al. Dig Dis. 2014;32(5):637-45. doi: 10.1159/000360518. Epub 2014 Jul 14. Dig Dis. 2014. PMID: 25034299 Review.
Chronic pruritus is a burdensome feature of numerous hepatobiliary disorders such as primary biliary cirrhosis, primary sclerosing cholangitis, cholangiocarcinoma, inherited forms of cholestasis and intrahepatic cholestasis of pregnancy. ...Treatment options for pat …
Chronic pruritus is a burdensome feature of numerous hepatobiliary disorders such as primary biliary cirrhosis, primary sclerosing
Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis.
Karlsen TH, Lie BA, Frey Frøslie K, Thorsby E, Broomé U, Schrumpf E, Boberg KM. Karlsen TH, et al. Gastroenterology. 2006 Sep;131(3):781-7. doi: 10.1053/j.gastro.2006.05.057. Gastroenterology. 2006. PMID: 16952547
We investigated whether functional polymorphisms of the SXR gene influence disease susceptibility or disease progression in patients with primary sclerosing cholangitis (PSC). ...CONCLUSIONS: Functional SXR gene variants appear to modify disease course …
We investigated whether functional polymorphisms of the SXR gene influence disease susceptibility or disease progression in patients …
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