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Bile acid malabsorption deactivates pregnane X receptor in patients with Crohn's disease.
Iwamoto J, Saito Y, Honda A, Miyazaki T, Ikegami T, Matsuzaki Y. Iwamoto J, et al. Inflamm Bowel Dis. 2013 May;19(6):1278-84. doi: 10.1097/MIB.0b013e318281f423. Inflamm Bowel Dis. 2013. PMID: 23574760
Because bile acid malabsorption is one of the features of CD and bile acids are potential activators of PXR, we explored the relationship between bile acid malabsorption and PXR activities in patients with CD. METHODS: Twenty-one patients with CD (4 ileal-resected a …
Because bile acid malabsorption is one of the features of CD and bile acids are potential activators of PXR, we explored the relation …
Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease.
Andersen V, Christensen J, Ernst A, Jacobsen BA, Tjønneland A, Krarup HB, Vogel U. Andersen V, et al. World J Gastroenterol. 2011 Jan 14;17(2):197-206. doi: 10.3748/wjg.v17.i2.197. World J Gastroenterol. 2011. PMID: 21245992 Free PMC article.
METHODS: Genotypes of nuclear factor (NF)-κB (NFKB1) NFκB -94ins/del (rs28362491); peroxisome proliferator-activated receptor (PPAR)-γ (PPARγ) PPARγ Pro12Ala (rs 1801282) and C1431T (rs 3856806); pregnane X receptor (PXR) (NR1I2) PXR A-24381C (rs1523127), C8055T (22 …
METHODS: Genotypes of nuclear factor (NF)-κB (NFKB1) NFκB -94ins/del (rs28362491); peroxisome proliferator-activated receptor (PPAR)-γ (PPAR …
Pregnane X Receptor Polymorphisms and Risk of Inflammatory Bowel Disease: A Meta-Analysis.
Guo X, Yan M. Guo X, et al. Immunol Invest. 2017 Aug;46(6):566-576. doi: 10.1080/08820139.2017.1322101. Epub 2017 Jul 25. Immunol Invest. 2017. PMID: 28742404
OBJECTIVE: The present meta-analysis was performed to assess the association between PXR gene polymorphisms and the susceptibility of IBD, Crohn's disease (CD), and ulcerative colitis (UC). ...ABBREVIATIONS: PXR = pregnane X receptor, IBD = inflammator …
OBJECTIVE: The present meta-analysis was performed to assess the association between PXR gene polymorphisms and the susceptibility of …
St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis off rats through the induction of pregnane X receptors and/or P-glycoproteins.
Sehirli AO, Cetinel S, Ozkan N, Selman S, Tetik S, Yuksel M, Dulger FG. Sehirli AO, et al. J Physiol Pharmacol. 2015 Apr;66(2):203-14. J Physiol Pharmacol. 2015. PMID: 25903951 Free article.
It is also known that the activation of PXR is protective of IBD due to the mutual repression between PXR and nuclear factor kappa B (NF-κB) expression and because NF-κB was reported to play a pivotal role in the pathogenesis of ulcerative colitis. ... …
It is also known that the activation of PXR is protective of IBD due to the mutual repression between PXR and nuclear factor k …
Hepatic early inflammation induces downregulation of hepatic cytochrome P450 expression and metabolic activity in the dextran sulfate sodium-induced murine colitis.
Kusunoki Y, Ikarashi N, Hayakawa Y, Ishii M, Kon R, Ochiai W, Machida Y, Sugiyama K. Kusunoki Y, et al. Eur J Pharm Sci. 2014 Apr 11;54:17-27. doi: 10.1016/j.ejps.2013.12.019. Epub 2014 Jan 8. Eur J Pharm Sci. 2014. PMID: 24413062
Ulcerative colitis (UC) patients may have increased concentrations of drugs in their blood. We hypothesized that this response is mainly due to a decrease in the expression and activity of the drug-metabolizing enzyme, cytochrome P450 (CYP), in the liver. ...In cont
Ulcerative colitis (UC) patients may have increased concentrations of drugs in their blood. We hypothesized that this response
Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease.
Glas J, Seiderer J, Fischer D, Tengler B, Pfennig S, Wetzke M, Beigel F, Olszak T, Weidinger M, Göke B, Ochsenkühn T, Folwaczny M, Müller-Myhsok B, Diegelmann J, Czamara D, Brand S. Glas J, et al. Inflamm Bowel Dis. 2011 Sep;17(9):1917-24. doi: 10.1002/ibd.21562. Epub 2010 Dec 3. Inflamm Bowel Dis. 2011. PMID: 21830270
METHODS: Genomic DNA from 2823 individuals of Caucasian origin including 859 patients with Crohn's disease (CD), 464 patients with ulcerative colitis (UC), and 1500 healthy, unrelated controls was analyzed for eight PXR/NR1I2 single nucleotide polymorphisms ( …
METHODS: Genomic DNA from 2823 individuals of Caucasian origin including 859 patients with Crohn's disease (CD), 464 patients with ulcera
Impact of experimental colitis on hepatobiliary transporter expression and bile duct injury in mice.
Jahnel J, Fickert P, Langner C, Högenauer C, Silbert D, Gumhold J, Fuchsbichler A, Trauner M. Jahnel J, et al. Liver Int. 2009 Oct;29(9):1316-25. doi: 10.1111/j.1478-3231.2009.02044.x. Epub 2009 Jun 24. Liver Int. 2009. PMID: 19558576
BACKGROUND AND AIMS: The pathogenetic link between ulcerative colitis and sclerosing cholangitis (SC) is unclear. We hypothesized that colitis induces changes in bile composition via inflammation-induced reduction of hepatobiliary transporter gene expression, …
BACKGROUND AND AIMS: The pathogenetic link between ulcerative colitis and sclerosing cholangitis (SC) is unclear. We hypothesi …
Tanshinone IIA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor.
Zhang X, Wang Y, Ma Z, Liang Q, Tang X, Hu D, Tan H, Xiao C, Gao Y. Zhang X, et al. Drug Des Devel Ther. 2015 Dec 7;9:6343-62. doi: 10.2147/DDDT.S79388. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 26674743 Free PMC article.
The current study demonstrated that Tan IIA is an efficacious PXR agonist and its ability to induce CYP3A4 mRNA and protein expression was mediated by the transactivation of PXR, a known target of abrogating inflammation in IBD. ...PXR-silenced mice treated w …
The current study demonstrated that Tan IIA is an efficacious PXR agonist and its ability to induce CYP3A4 mRNA and protein expressio …
Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.
Dou W, Zhang J, Li H, Kortagere S, Sun K, Ding L, Ren G, Wang Z, Mani S. Dou W, et al. J Nutr Biochem. 2014 Sep;25(9):923-33. doi: 10.1016/j.jnutbio.2014.04.006. Epub 2014 May 9. J Nutr Biochem. 2014. PMID: 24913217 Free PMC article.
Using two different models (ulcerative colitis like and Crohn's disease like) of experimental IBD in mice, we demonstrated that isorhamnetin abrogated inflammation through inhibiting the activity of myeloperoxidase, the levels of TNF-α and IL-6, the mRNA expression …
Using two different models (ulcerative colitis like and Crohn's disease like) of experimental IBD in mice, we demonstrated tha …
Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation.
Cheng J, Shah YM, Ma X, Pang X, Tanaka T, Kodama T, Krausz KW, Gonzalez FJ. Cheng J, et al. J Pharmacol Exp Ther. 2010 Oct;335(1):32-41. doi: 10.1124/jpet.110.170225. Epub 2010 Jul 13. J Pharmacol Exp Ther. 2010. PMID: 20627999 Free PMC article.
Human pregnane X receptor (PXR) has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Rifaximin, a human PXR activator, is in clinical trials for treatment of IBD and has demonstrated efficacy in Crohn's disease and active ulcerative
Human pregnane X receptor (PXR) has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Rifaximin, a human PX
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