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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 9
1994 14
1995 30
1996 45
1997 34
1998 52
1999 41
2000 75
2001 79
2002 93
2003 110
2004 131
2005 142
2006 136
2007 171
2008 172
2009 187
2010 202
2011 218
2012 247
2013 257
2014 289
2015 264
2016 299
2017 338
2018 300
2019 296
2020 254
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4,026 results
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Page 1
Role of RUNX1 in hematological malignancies.
Sood R, Kamikubo Y, Liu P. Sood R, et al. Blood. 2017 Apr 13;129(15):2070-2082. doi: 10.1182/blood-2016-10-687830. Epub 2017 Feb 8. Blood. 2017. PMID: 28179279 Free PMC article. Review.
RUNX1 is one of the most frequently mutated genes in a variety of hematological malignancies. Germ line mutations in RUNX1 cause familial platelet disorder with associated myeloid malignancies. ...More recent studies suggest that the wild-type RUNX1 is requir
RUNX1 is one of the most frequently mutated genes in a variety of hematological malignancies. Germ line mutations in RUNX1 cau
RUNX1: A Regulator of NF-kB Signaling in Pulmonary Diseases.
Tang X, Sun L, Wang G, Chen B, Luo F. Tang X, et al. Curr Protein Pept Sci. 2018;19(2):172-178. doi: 10.2174/1389203718666171009111835. Curr Protein Pept Sci. 2018. PMID: 28990531 Free PMC article. Review.
RUNX1 is involved in embryonic development, hematopoiesis, angiogenesis, tumorigenesis and immune response. In the past few decades, studies mainly focused on the effect of RUNX1 on acute leukemia and cancer. ...This review is to highlight the RUNX1 structure
RUNX1 is involved in embryonic development, hematopoiesis, angiogenesis, tumorigenesis and immune response. In the past few decades,
ETV6/RUNX1-positive childhood acute lymphoblastic leukemia (ALL): The spectrum of clonal heterogeneity and its impact on prognosis.
Ampatzidou M, Papadhimitriou SI, Paterakis G, Pavlidis D, Tsitsikas Κ, Kostopoulos IV, Papadakis V, Vassilopoulos G, Polychronopoulou S. Ampatzidou M, et al. Cancer Genet. 2018 Aug;224-225:1-11. doi: 10.1016/j.cancergen.2018.03.001. Epub 2018 Mar 27. Cancer Genet. 2018. PMID: 29778230
The prognostic significance of the ETV6/RUNX1-fusion and of the accompanying aberrations is disputable; whether co-existing sub-clones are responsible for delayed MRD-clearance and thus, moderate outcome, remains to be clarified. ...In our study, the presence of clonal het …
The prognostic significance of the ETV6/RUNX1-fusion and of the accompanying aberrations is disputable; whether co-existing sub-clone …
RUNX1-dependent mechanisms in biological control and dysregulation in cancer.
Hong D, Fritz AJ, Gordon JA, Tye CE, Boyd JR, Tracy KM, Frietze SE, Carr FE, Nickerson JA, Van Wijnen AJ, Imbalzano AN, Zaidi SK, Lian JB, Stein JL, Stein GS. Hong D, et al. J Cell Physiol. 2019 Jun;234(6):8597-8609. doi: 10.1002/jcp.27841. Epub 2018 Dec 4. J Cell Physiol. 2019. PMID: 30515788 Free PMC article. Review.
Compromised RUNX1 regulation is associated with many cancers. In this review, we highlight evidence for RUNX1 control in both invertebrate and mammalian development and recent novel findings of perturbed RUNX1 control in breast cancer that has implications fo …
Compromised RUNX1 regulation is associated with many cancers. In this review, we highlight evidence for RUNX1 control in both …
RUNX1 Mutations in Inherited and Sporadic Leukemia.
Bellissimo DC, Speck NA. Bellissimo DC, et al. Front Cell Dev Biol. 2017 Dec 20;5:111. doi: 10.3389/fcell.2017.00111. eCollection 2017. Front Cell Dev Biol. 2017. PMID: 29326930 Free PMC article. Review.
RUNX1 is a recurrently mutated gene in sporadic myelodysplastic syndrome and leukemia. Inherited mutations in RUNX1 cause familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML). In sporadic AML, mutations in RUNX1 are usually secon
RUNX1 is a recurrently mutated gene in sporadic myelodysplastic syndrome and leukemia. Inherited mutations in RUNX1 cause fami
Modeling the process of childhood ETV6-RUNX1 B-cell leukemias.
Rodríguez-Hernández G, Schäfer D, Gavilán A, Vicente-Dueñas C, Hauer J, Borkhardt A, Sánchez-García I. Rodríguez-Hernández G, et al. Oncotarget. 2017 Sep 27;8(60):102674-102680. doi: 10.18632/oncotarget.21281. eCollection 2017 Nov 24. Oncotarget. 2017. PMID: 29254279 Free PMC article. Review.
ETV6-RUNX1 is associated with the most common subtype of childhood leukemia. Pre-leukaemic clones carrying ETV6-RUNX1 oncogenic lesions are frequently found in neonatal cord blood, but only few ETV6-RUNX1 carriers develop pB-ALL. ...However, the lack of a gen …
ETV6-RUNX1 is associated with the most common subtype of childhood leukemia. Pre-leukaemic clones carrying ETV6-RUNX1 oncogeni …
ETV6/RUNX1-like acute lymphoblastic leukemia: A novel B-cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype.
Zaliova M, Kotrova M, Bresolin S, Stuchly J, Stary J, Hrusak O, Te Kronnie G, Trka J, Zuna J, Vaskova M. Zaliova M, et al. Genes Chromosomes Cancer. 2017 Aug;56(8):608-616. doi: 10.1002/gcc.22464. Epub 2017 May 5. Genes Chromosomes Cancer. 2017. PMID: 28395118
We aimed to elucidate whether these cases belong to the recently described ETV6/RUNX1-like ALL defined by the ETV6/RUNX1-specific gene expression profile (GEP), harboring concurrent ETV6 and IKZF1 lesions. ...All five ETV6/RUNX1-like cases harbored ETV6 delet …
We aimed to elucidate whether these cases belong to the recently described ETV6/RUNX1-like ALL defined by the ETV6/RUNX1-speci …
Mechanism of ETV6-RUNX1 Leukemia.
Sundaresh A, Williams O. Sundaresh A, et al. Adv Exp Med Biol. 2017;962:201-216. doi: 10.1007/978-981-10-3233-2_13. Adv Exp Med Biol. 2017. PMID: 28299659 Review.
This translocation results in the fusion of the ETV6 and RUNX1 genes. Since its discovery in the 1990s, the function of the ETV6-RUNX1 fusion gene has attracted intense interest. In this chapter, we will summarize current knowledge on the clinical significance of ET …
This translocation results in the fusion of the ETV6 and RUNX1 genes. Since its discovery in the 1990s, the function of the ETV6-R
Long non-coding RNA RUNX1-IT1 plays a tumour-suppressive role in colorectal cancer by inhibiting cell proliferation and migration.
Shi J, Zhong X, Song Y, Wu Z, Gao P, Zhao J, Sun J, Wang J, Liu J, Wang Z. Shi J, et al. Cell Biochem Funct. 2019 Jan;37(1):11-20. doi: 10.1002/cbf.3368. Epub 2018 Nov 30. Cell Biochem Funct. 2019. PMID: 30499136
Moreover, the proliferative and migration potential of CRC cells were inhibited by overexpressing lncRNA RUNX1-IT1, which could be obviously improved by knocking down lncRNA RUNX1-IT1. The protein levels of PCNA, Ki67, and MMP9 were upregulated by overexpressing lnc …
Moreover, the proliferative and migration potential of CRC cells were inhibited by overexpressing lncRNA RUNX1-IT1, which could be ob …
Detection of rare reciprocal RUNX1 rearrangements by next-generation sequencing in acute myeloid leukemia.
Flach J, Shumilov E, Joncourt R, Porret N, Tchinda J, Legros M, Scarpelli I, Hewer E, Novak U, Schoumans J, Bacher U, Pabst T. Flach J, et al. Genes Chromosomes Cancer. 2020 Apr;59(4):268-274. doi: 10.1002/gcc.22829. Epub 2019 Dec 2. Genes Chromosomes Cancer. 2020. PMID: 31756777
Reciprocal RUNX1 fusions are traditionally found in up to 10% of acute myeloid leukemia (AML) patients, usually associated with a translocation (8;21)(q22;q22) corresponding to the RUNX1-RUNX1T1 fusion gene. ...These include t(16;21)(q24;q22)/RUNX1-CBFA2T3 an …
Reciprocal RUNX1 fusions are traditionally found in up to 10% of acute myeloid leukemia (AML) patients, usually associated with a tra …
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