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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2003 5
2004 3
2005 7
2006 8
2007 3
2008 3
2009 4
2010 2
2011 2
2012 3
2013 3
2014 6
2015 6
2016 3
2017 3
2018 4
2019 1
2020 2
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60 results
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Page 1
Molecular mechanisms underpinning T helper 17 cell heterogeneity and functions in rheumatoid arthritis.
van Hamburg JP, Tas SW. van Hamburg JP, et al. J Autoimmun. 2018 Feb;87:69-81. doi: 10.1016/j.jaut.2017.12.006. Epub 2017 Dec 16. J Autoimmun. 2018. PMID: 29254845 Free article. Review.
Interactions between Th17 cells and other immune cells or stromal cells that are present in the synovial tissue during the earliest phases of the disease, may eventually lead to chronic inflammation, irreversible cartilage degradation and bone erosions. ...This review prov …
Interactions between Th17 cells and other immune cells or stromal cells that are present in the synovial tissue during the earliest phases o …
Identification of RUNX1 as a Mediator of Aberrant Retinal Angiogenesis.
Lam JD, Oh DJ, Wong LL, Amarnani D, Park-Windhol C, Sanchez AV, Cardona-Velez J, McGuone D, Stemmer-Rachamimov AO, Eliott D, Bielenberg DR, van Zyl T, Shen L, Gai X, D'Amore PA, Kim LA, Arboleda-Velasquez JF. Lam JD, et al. Diabetes. 2017 Jul;66(7):1950-1956. doi: 10.2337/db16-1035. Epub 2017 Apr 11. Diabetes. 2017. PMID: 28400392 Free PMC article.
In vitro studies using human retinal microvascular endothelial cells (HRMECs) showed increased RUNX1 RNA and protein expression in response to high glucose, whereas RUNX1 inhibition reduced HRMEC migration, proliferation, and tube formation. ...Inhibition of RUNX
In vitro studies using human retinal microvascular endothelial cells (HRMECs) showed increased RUNX1 RNA and protein expression in re …
Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells.
Wong WF, Kohu K, Nakamura A, Ebina M, Kikuchi T, Tazawa R, Tanaka K, Kon S, Funaki T, Sugahara-Tobinai A, Looi CY, Endo S, Funayama R, Kurokawa M, Habu S, Ishii N, Fukumoto M, Nakata K, Takai T, Satake M. Wong WF, et al. J Immunol. 2012 Jun 1;188(11):5408-20. doi: 10.4049/jimmunol.1102991. Epub 2012 May 2. J Immunol. 2012. PMID: 22551552 Free article.
The Runx1 transcription factor is abundantly expressed in naive T cells but rapidly downregulated in activated T cells, suggesting that it plays an important role in a naive stage. In the current study, Runx1(-/-)Bcl2(tg) mice harboring Runx1-deleted CD4(+) T …
The Runx1 transcription factor is abundantly expressed in naive T cells but rapidly downregulated in activated T cells, suggesting th …
Non-del(5q) myelodysplastic syndromes-associated loci detected by SNP-array genome-wide association meta-analysis.
McGraw KL, Cheng CH, Chen YA, Hou HA, Nilsson B, Genovese G, Cluzeau T, Pellagatti A, Przychodzen BP, Mallo M, Arenillas L, Mohamedali A, Adès L, Sallman DA, Padron E, Sokol L, Moreilhon C, Raynaud S, Tien HF, Boultwood J, Ebert BL, Sole F, Fenaux P, Mufti GJ, Maciejewski JP, Kanetsky PA, List AF. McGraw KL, et al. Blood Adv. 2019 Nov 26;3(22):3579-3589. doi: 10.1182/bloodadvances.2019000922. Blood Adv. 2019. PMID: 31738830 Free PMC article.

Known predisposing factors to adult MDS include rare germline mutations, cytotoxic therapy, age-related clonal hematopoiesis, and autoimmune or chronic inflammatory disorders. ...Higher PLA2G4A expression is associated with mutations in NRAS (P < .001), RUNX1 (P

Known predisposing factors to adult MDS include rare germline mutations, cytotoxic therapy, age-related clonal hematopoiesis, and autoimm
SLC22A4 and RUNX1: identification of RA susceptible genes.
Yamada R, Tokuhiro S, Chang X, Yamamoto K. Yamada R, et al. J Mol Med (Berl). 2004 Sep;82(9):558-64. doi: 10.1007/s00109-004-0547-y. Epub 2004 Jun 4. J Mol Med (Berl). 2004. PMID: 15184985 Review.
Recently we reported that SLC22A4 and RUNX1 are associated with rheumatoid arthritis (RA). SLC22A4 is an organic cation transporter with unknown physiological function, and RUNX1 is a hematological transcriptional regulator that has been shown to be responsible for …
Recently we reported that SLC22A4 and RUNX1 are associated with rheumatoid arthritis (RA). SLC22A4 is an organic cation transporter w …
Meta-analysis of SLC22A4 and RUNX1 polymorphisms : Associations with rheumatoid arthritis susceptibility.
Lee YH, Bae SC, Kim JH, Seo YH, Choi SJ, Ji JD, Song GG. Lee YH, et al. Z Rheumatol. 2015 May;74(4):351-8. doi: 10.1007/s00393-014-1447-3. Z Rheumatol. 2015. PMID: 24972750 Review.
OBJECTIVE: The aim in this study was to determine whether solute carrier family 22, member 4 (SLC22A4), and runt-related transcription factor 1 (RUNX1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) in populations of different ethnicities. .. …
OBJECTIVE: The aim in this study was to determine whether solute carrier family 22, member 4 (SLC22A4), and runt-related transcription facto …
SLC22A4, RUNX1, and SUMO4 polymorphisms are not associated with rheumatoid arthritis: a case-control study in a Spanish population.
Orozco G, Sánchez E, González-Gay MA, López-Nevot MA, Torres B, Pascual-Salcedo D, Balsa A, Pablos JL, García A, González-Escribano MF, Martín J. Orozco G, et al. J Rheumatol. 2006 Jul;33(7):1235-9. J Rheumatol. 2006. PMID: 16821265
OBJECTIVE: To replicate the association reported in Japanese individuals of functional SLC22A4 and RUNX1 polymorphisms with rheumatoid arthritis (RA), and to test the possible role in this trait of a functional variant of the SUMO4 gene that was shown to be associated with …
OBJECTIVE: To replicate the association reported in Japanese individuals of functional SLC22A4 and RUNX1 polymorphisms with rheumatoi …
Decreased expression of Runx1 and lowered proportion of Foxp3⁺ CD25⁺ CD4⁺ regulatory T cells in systemic sclerosis.
Kataoka H, Yasuda S, Fukaya S, Oku K, Horita T, Atsumi T, Koike T. Kataoka H, et al. Mod Rheumatol. 2015 Jan;25(1):90-5. doi: 10.3109/14397595.2014.899736. Epub 2014 Apr 9. Mod Rheumatol. 2015. PMID: 24716598
Runx1 mRNA expression level was related to the frequency of Treg in SSc. CONCLUSIONS: This is the first report on Runx1 expression in Treg of a human autoimmune disease. Low expression of Runx1 along with reduced proportion of Treg in CD4(+) T c
Runx1 mRNA expression level was related to the frequency of Treg in SSc. CONCLUSIONS: This is the first report on Runx1 expres
Identification of Casz1 as a Regulatory Protein Controlling T Helper Cell Differentiation, Inflammation, and Immunity.
Bhaskaran N, Liu Z, Saravanamuthu SS, Yan C, Hu Y, Dong L, Zelenka P, Zheng L, Bletsos V, Harris R, Harrington B, Weinberg A, Thiele CJ, Ye F, Pandiyan P. Bhaskaran N, et al. Front Immunol. 2018 Feb 7;9:184. doi: 10.3389/fimmu.2018.00184. eCollection 2018. Front Immunol. 2018. PMID: 29467767 Free PMC article.
With regards to Th17 differentiation, Casz1 limits repressive histone marks and enables acquisition of permissive histone marks at Rorc, Il17a, Ahr, and Runx1 loci. Taken together, these data identify Casz1 as a new Th plasticity regulator having important clinical implica …
With regards to Th17 differentiation, Casz1 limits repressive histone marks and enables acquisition of permissive histone marks at Rorc, Il1 …
Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus.
Alarcón-Riquelme ME. Alarcón-Riquelme ME. Arthritis Res Ther. 2004;6(4):169-73. doi: 10.1186/ar1203. Epub 2004 Jun 21. Arthritis Res Ther. 2004. PMID: 15225361 Free PMC article. Review.
Recent studies investigating the genetic susceptibility of systemic lupus erythematosus, rheumatoid arthritis and psoriasis have revealed a potential role for the RUNX proteins in the development of autoimmune disease. A new pathway of disease pathogenesis op …
Recent studies investigating the genetic susceptibility of systemic lupus erythematosus, rheumatoid arthritis and psoriasis have revealed a …
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