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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 3
1991 1
1992 1
1993 3
1994 4
1995 5
1996 2
1998 9
2000 14
2001 34
2002 69
2003 90
2004 135
2005 160
2006 193
2007 240
2008 274
2009 315
2010 424
2011 453
2012 561
2013 603
2014 683
2015 692
2016 770
2017 837
2018 888
2019 931
2020 980
2021 93
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8,238 results
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Runx2, an inducer of osteoblast and chondrocyte differentiation.
Komori T. Komori T. Histochem Cell Biol. 2018 Apr;149(4):313-323. doi: 10.1007/s00418-018-1640-6. Epub 2018 Jan 22. Histochem Cell Biol. 2018. PMID: 29356961 Review.
Runx2 enhances chondrocyte proliferation through the induction of Ihh. ...Runx2 is one of the genes responsible for the pathogenesis of osteoarthritis (OA) because RUNX2 is up-regulated in chondrocytes in OA cartilage and a germline haplodeficiency or deletio
Runx2 enhances chondrocyte proliferation through the induction of Ihh. ...Runx2 is one of the genes responsible for the pathog
Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2.
Komori T. Komori T. Int J Mol Sci. 2019 Apr 4;20(7):1694. doi: 10.3390/ijms20071694. Int J Mol Sci. 2019. PMID: 30987410 Free PMC article. Review.
Runx2 is essential for osteoblast differentiation and chondrocyte maturation. ...Runx2 heterozygous mutation causes open fontanelle and sutures because more than half of the Runx2 gene dosage is required for the induction of these genes in suture mesenchymal
Runx2 is essential for osteoblast differentiation and chondrocyte maturation. ...Runx2 heterozygous mutation causes open fonta
Molecular Mechanism of Runx2-Dependent Bone Development.
Komori T. Komori T. Mol Cells. 2020 Feb 29;43(2):168-175. doi: 10.14348/molcells.2019.0244. Mol Cells. 2020. PMID: 31896233 Free PMC article. Review.
Runx2 is an essential transcription factor for skeletal development. ...This is a major cause of cleidocranial dysplasia, which is caused by heterozygous mutation of RUNX2. Cbfb, which is a co-transcription factor that forms a heterodimer with Runx2, enhances
Runx2 is an essential transcription factor for skeletal development. ...This is a major cause of cleidocranial dysplasia, which is ca
Roles of Runx2 in Skeletal Development.
Komori T. Komori T. Adv Exp Med Biol. 2017;962:83-93. doi: 10.1007/978-981-10-3233-2_6. Adv Exp Med Biol. 2017. PMID: 28299652 Review.
Runx2 is the most upstream transcription factor essential for osteoblast differentiation. ...Runx2 regulates the expression of Col10a1, Spp1, Ibsp, and Mmp13 in chondrocytes. ...
Runx2 is the most upstream transcription factor essential for osteoblast differentiation. ...Runx2 regulates the expression of
Cleidocranial dysplasia and RUNX2-clinical phenotype-genotype correlation.
Jaruga A, Hordyjewska E, Kandzierski G, Tylzanowski P. Jaruga A, et al. Clin Genet. 2016 Nov;90(5):393-402. doi: 10.1111/cge.12812. Epub 2016 Jun 30. Clin Genet. 2016. PMID: 27272193 Review.
Runt-related transcription factor 2 (RUNX2/Cbfa1) is the main regulatory gene controlling skeletal development and morphogenesis in vertebrates. It is located on chromosome 6p21 and has two functional isoforms (type I and type II) under control of two alternate promoters ( …
Runt-related transcription factor 2 (RUNX2/Cbfa1) is the main regulatory gene controlling skeletal development and morphogenesis in v …
Runx2: Structure, function, and phosphorylation in osteoblast differentiation.
Vimalraj S, Arumugam B, Miranda PJ, Selvamurugan N. Vimalraj S, et al. Int J Biol Macromol. 2015;78:202-8. doi: 10.1016/j.ijbiomac.2015.04.008. Epub 2015 Apr 13. Int J Biol Macromol. 2015. PMID: 25881954 Review.
Runx2 is a master transcription factor for osteogenesis. The most important phenomenon that makes this protein a master regulator for osteogenesis is its structural integrity. In response to various stimuli, the domains in Runx2 interact with several proteins and re
Runx2 is a master transcription factor for osteogenesis. The most important phenomenon that makes this protein a master regulator for
Regulation of Runx2 by MicroRNAs in osteoblast differentiation.
Narayanan A, Srinaath N, Rohini M, Selvamurugan N. Narayanan A, et al. Life Sci. 2019 Sep 1;232:116676. doi: 10.1016/j.lfs.2019.116676. Epub 2019 Jul 21. Life Sci. 2019. PMID: 31340165 Review.
The process of osteogenesis is achieved through participation of the Wnt pathway, FGFs, BMPs/TGF-beta, and transcription factors such as Runx2 and Osx. The activity and function of the master transcription factor, Runx2, is of utmost significance as it can induce th …
The process of osteogenesis is achieved through participation of the Wnt pathway, FGFs, BMPs/TGF-beta, and transcription factors such as …
Osteoclast-derived miR-23a-5p-containing exosomes inhibit osteogenic differentiation by regulating Runx2.
Yang JX, Xie P, Li YS, Wen T, Yang XC. Yang JX, et al. Cell Signal. 2020 Jun;70:109504. doi: 10.1016/j.cellsig.2019.109504. Epub 2019 Dec 16. Cell Signal. 2020. PMID: 31857240
Furthermore, the number and distribution of osteoclasts were detected by TRAP staining, and early osteogenesis was evaluated by ALP staining. Combination of YAP1 and Runx2 was verified by Co-IP assay, and the regulation of miR-23a-5p and Runx2 was measured by dual l …
Furthermore, the number and distribution of osteoclasts were detected by TRAP staining, and early osteogenesis was evaluated by ALP staining …
Regulation of osteoblast differentiation by Runx2.
Komori T. Komori T. Adv Exp Med Biol. 2010;658:43-9. doi: 10.1007/978-1-4419-1050-9_5. Adv Exp Med Biol. 2010. PMID: 19950014
Runx2 induces the differentiation of multipotent mesenchymal cells into immature osteoblasts, directing the formation of immature bone, but Runx2 inhibits osteoblast maturation and mature bone formation. ...Furthermore, Runx2 triggers the expression of major
Runx2 induces the differentiation of multipotent mesenchymal cells into immature osteoblasts, directing the formation of immature bon
Regulation of Runx2 by post-translational modifications in osteoblast differentiation.
Gomathi K, Akshaya N, Srinaath N, Moorthi A, Selvamurugan N. Gomathi K, et al. Life Sci. 2020 Mar 15;245:117389. doi: 10.1016/j.lfs.2020.117389. Epub 2020 Jan 30. Life Sci. 2020. PMID: 32007573 Review.
Runx2 acts as a modulator such that it can either stimulate or inhibit the osteoblast differentiation. A defect/alteration in the expression/activity of this gene may lead to skeletal dysplasia. Runx2 thus serves as the best therapeutic model gene for studying bone
Runx2 acts as a modulator such that it can either stimulate or inhibit the osteoblast differentiation. A defect/alteration in the exp
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