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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 2
2001 7
2002 18
2003 29
2004 46
2005 42
2006 51
2007 64
2008 78
2009 83
2010 76
2011 106
2012 83
2013 100
2014 101
2015 104
2016 83
2017 112
2018 97
2019 93
2020 111
2021 11
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1,335 results
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The correlation between Runx3 and bronchial asthma.
Yu Y, Wang L, Gu G. Yu Y, et al. Clin Chim Acta. 2018 Dec;487:75-79. doi: 10.1016/j.cca.2018.09.023. Epub 2018 Sep 12. Clin Chim Acta. 2018. PMID: 30218658 Free article. Review.
Accumulated evidence indicated that altered expression of Runx3 regulates a variety of target genes in different tissues/cells. ...Specifically, Runx3 modulates Th1/Th2 balance and hence, the production of interleukins, which induce inflammatory responses. ...
Accumulated evidence indicated that altered expression of Runx3 regulates a variety of target genes in different tissues/cells. ...Sp …
Oncosuppressive Role of RUNX3 in Human Astrocytomas.
Steponaitis G, Kazlauskas A, Vaitkienė P, Deltuva VP, Mikuciunas M, Skiriutė D. Steponaitis G, et al. J Oncol. 2019 Aug 5;2019:1232434. doi: 10.1155/2019/1232434. eCollection 2019. J Oncol. 2019. PMID: 31467531 Free PMC article.
AIM: The aim of the study was to elucidate RUNX3 changes in different regulation levels of molecular biology starting from epigenetics to function in particular cases of astrocytic origin tumours of different grade evaluating significance of molecular changes of RUNX3 …
AIM: The aim of the study was to elucidate RUNX3 changes in different regulation levels of molecular biology starting from epigenetic …
Runx3 in Immunity, Inflammation and Cancer.
Lotem J, Levanon D, Negreanu V, Bauer O, Hantisteanu S, Dicken J, Groner Y. Lotem J, et al. Adv Exp Med Biol. 2017;962:369-393. doi: 10.1007/978-981-10-3233-2_23. Adv Exp Med Biol. 2017. PMID: 28299669 Review.
More than a decade ago it was suggested that RUNX3 is involved in gastric cancer development, a postulate extended later to other epithelial cancers portraying RUNX3 as a major TSG. However, evidence that Runx3 is not expressed in normal gastric and other epi …
More than a decade ago it was suggested that RUNX3 is involved in gastric cancer development, a postulate extended later to other epi …
Disruption of super-enhancer-driven tumor suppressor gene RCAN1.4 expression promotes the malignancy of breast carcinoma.
Deng R, Huang JH, Wang Y, Zhou LH, Wang ZF, Hu BX, Chen YH, Yang D, Mai J, Li ZL, Zhang HL, Huang Y, Peng XD, Feng GK, Zhu XF, Tang J. Deng R, et al. Mol Cancer. 2020 Aug 8;19(1):122. doi: 10.1186/s12943-020-01236-z. Mol Cancer. 2020. PMID: 32771023 Free PMC article.
ChIP-seq data analysis, ChIP-qPCR, double-CRISPR genome editing, and luciferase reporter assay were utilized to confirm RUNX3 was involved in regulating RCAN1.4-associated SE in BC. The clinical value of co-expression of RCAN1.4 and RUNX3 was evaluated in BC patient …
ChIP-seq data analysis, ChIP-qPCR, double-CRISPR genome editing, and luciferase reporter assay were utilized to confirm RUNX3 was inv …
RUNX3-Mediated Immune Cell Development and Maturation.
Boto P, Csuth TI, Szatmari I. Boto P, et al. Crit Rev Immunol. 2018;38(1):63-78. doi: 10.1615/CritRevImmunol.2018025488. Crit Rev Immunol. 2018. PMID: 29717663 Review.
The transcription factor RUNX3 is a prominent regulator of multiple hematopoietic cell lineages. ...In this report, we overview the immunomodulatory functions of RUNX3 within the hematopoietic compartment to gain insight into the consequences of Runx3 deletio …
The transcription factor RUNX3 is a prominent regulator of multiple hematopoietic cell lineages. ...In this report, we overview the i …
RUNX3-dependent oxidative epithelial-to-mesenchymal transition in methamphetamine-induced chronic lung injury.
Shi L, Liu BY, Wang X, Zhu MJ, Chen L, Zhou MY, Gu YJ, Cheng L, Wang Y. Shi L, et al. Cell Stress Chaperones. 2020 Sep;25(5):793-802. doi: 10.1007/s12192-020-01133-w. Epub 2020 Jul 17. Cell Stress Chaperones. 2020. PMID: 32681471
Long-term administration with MA caused oxidative stress and pulmonary EMT. NAC increased RUNX3 and alleviated EMT. However, after knockdown of RUNX3, reactive oxygen species (ROS) levels were significantly upregulated, indicating that RUNX3 was closely relat …
Long-term administration with MA caused oxidative stress and pulmonary EMT. NAC increased RUNX3 and alleviated EMT. However, after kn …
RUNX3 methylation drives hypoxia-induced cell proliferation and antiapoptosis in early tumorigenesis.
Lee SH, Hyeon DY, Yoon SH, Jeong JH, Han SM, Jang JW, Nguyen MP, Chi XZ, An S, Hyun KG, Jung HJ, Song JJ, Bae SC, Kim WH, Hwang D, Lee YM. Lee SH, et al. Cell Death Differ. 2020 Oct 28. doi: 10.1038/s41418-020-00647-1. Online ahead of print. Cell Death Differ. 2020. PMID: 33116296
Inactivation of tumor suppressor Runt-related transcription factor 3 (RUNX3) plays an important role during early tumorigenesis. However, posttranslational modifications (PTM)-based mechanism for the inactivation of RUNX3 under hypoxia is still not fully understood. …
Inactivation of tumor suppressor Runt-related transcription factor 3 (RUNX3) plays an important role during early tumorigenesis. Howe …
Transcription factor RUNX3 promotes CD8(+) T cell recruitment by CCL3 and CCL20 in lung adenocarcinoma immune microenvironment.
Song Q, Shang J, Zhang C, Chen J, Zhang L, Wu X. Song Q, et al. J Cell Biochem. 2020 Jun;121(5-6):3208-3220. doi: 10.1002/jcb.29587. Epub 2020 Jan 3. J Cell Biochem. 2020. PMID: 31898342
These chemokines were further confirmed in RUNX3-downregulated cell lines. Immunochemistry was conducted to determine the expression of RUNX3, CCL3, CCL20, and the numbers of CD8(+) T lymphocytes in human lung cancer tissues. ...Further investigation exhibited RU …
These chemokines were further confirmed in RUNX3-downregulated cell lines. Immunochemistry was conducted to determine the expression …
Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation.
Date Y, Ito K. Date Y, et al. Mol Cells. 2020 Feb 29;43(2):176-181. doi: 10.14348/molcells.2019.0285. Mol Cells. 2020. PMID: 31991537 Free PMC article. Review.
This idea is mainly based on the observation that RUNX3 is inactivated by genetic/epigenetic alterations or protein mislocalization during the initiation of tumorigenesis. ...We propose a simple explanation for the duality of RUNX3: p53 status. In this model, p53 de …
This idea is mainly based on the observation that RUNX3 is inactivated by genetic/epigenetic alterations or protein mislocalization d …
Muscle-selective RUNX3 dependence of sensorimotor circuit development.
Wang Y, Wu H, Zelenin P, Fontanet P, Wanderoy S, Petitpré C, Comai G, Bellardita C, Xue-Franzén Y, Huettl RE, Huber AB, Tajbakhsh S, Kiehn O, Ernfors P, Deliagina TG, Lallemend F, Hadjab S. Wang Y, et al. Development. 2019 Oct 24;146(20):dev181750. doi: 10.1242/dev.181750. Development. 2019. PMID: 31575648 Free PMC article.
Here, we conditionally inactivate Runx3 in PSNs after peripheral innervation and identify that RUNX3 is necessary for maintenance of cell identity of only a subgroup of PSNs, without discernable cell death. RUNX3 also controls the sensorimotor connection betw …
Here, we conditionally inactivate Runx3 in PSNs after peripheral innervation and identify that RUNX3 is necessary for maintena …
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