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Aberrant methylation of HTATIP2 and UCHL1 as a predictive biomarker for cholangiocarcinoma.
Nanok C, Jearanaikoon P, Proungvitaya S, Limpaiboon T. Nanok C, et al. Mol Med Rep. 2018 Mar;17(3):4145-4153. doi: 10.3892/mmr.2017.8319. Epub 2017 Dec 19. Mol Med Rep. 2018. PMID: 29359783
Cholangiocarcinoma (CCA) is the most common primary liver cancer in Northeastern Thailand where liver fluke infection is highly endemic. ...In the present study, the results obtained from our previously published methylation array were analyzed and 10 candidate genes invol
Cholangiocarcinoma (CCA) is the most common primary liver cancer in Northeastern Thailand where liver fluke infection is highly endem
Two classes of intrahepatic cholangiocarcinoma defined by relative abundance of mutations and copy number alterations.
Kim YH, Hong EK, Kong SY, Han SS, Kim SH, Rhee JK, Hwang SK, Park SJ, Kim TM. Kim YH, et al. Oncotarget. 2016 Apr 26;7(17):23825-36. doi: 10.18632/oncotarget.8183. Oncotarget. 2016. PMID: 27009864 Free PMC article.
Intrahepatic cholangiocarcinoma (ICC) is a biliary tree-origin epithelial malignancy in liver with unfavorable clinical outcomes. ...Compared to M class ICCs (92-147 somatic mutations; n = 5) with a relative deficit of CNAs, C class ICCs (54-84 mutations; n = 5) harbor rec …
Intrahepatic cholangiocarcinoma (ICC) is a biliary tree-origin epithelial malignancy in liver with unfavorable clinical outcomes. ... …
CpG island hypermethylation and repetitive DNA hypomethylation in premalignant lesion of extrahepatic cholangiocarcinoma.
Kim BH, Cho NY, Shin SH, Kwon HJ, Jang JJ, Kang GH. Kim BH, et al. Virchows Arch. 2009 Oct;455(4):343-51. doi: 10.1007/s00428-009-0829-4. Epub 2009 Sep 10. Virchows Arch. 2009. PMID: 19763613
Biliary intraepithelial neoplasia (BilIN) is the premalignant lesion of extrahepatic cholangiocarcinoma (EHC), and there are no published data regarding epigenetic changes throughout disease progression from normal biliary epithelia to BilIN to EHC. ...The methylation leve …
Biliary intraepithelial neoplasia (BilIN) is the premalignant lesion of extrahepatic cholangiocarcinoma (EHC), and there are no publi …
DNA copy-number loss on 1p36.1 harboring RUNX3 with promoter hypermethylation and associated loss of RUNX3 expression in liver fluke-associated intrahepatic cholangiocarcinoma.
Dachrut S, Banthaisong S, Sripa M, Paeyao A, Ho C, Lee SA, Kosinski C, Patil MA, Zhang J, Chen X, Sripa B, Pairojkul C. Dachrut S, et al. Asian Pac J Cancer Prev. 2009 Oct-Dec;10(4):575-82. Asian Pac J Cancer Prev. 2009. PMID: 19827872 Free article.
To assess its role in liver fluke-associated intrahepatic cholangiocarcinoma (ICC), the promoter methylation status was investigated in 53 ICCs by methylation-specific PCR, with determination of loss of 1p36.1 by microarray comparative genomic hybridization and RUNX3
To assess its role in liver fluke-associated intrahepatic cholangiocarcinoma (ICC), the promoter methylation status was investigated …
EZH2 elevates the proliferation of human cholangiocarcinoma cells through the downregulation of RUNX3.
Tang B, Du J, Li Y, Tang F, Wang Z, He S. Tang B, et al. Med Oncol. 2014 Nov;31(11):271. doi: 10.1007/s12032-014-0271-6. Epub 2014 Oct 4. Med Oncol. 2014. PMID: 25280519
Immunohistochemistry and Western blot analyses were used to examine the expression of EZH2 in 40 cases of human cholangiocarcinoma tissues and four strains of human cholangiocarcinoma cells. ...EZH2 was highly expressed in human cholangiocarcinoma tissues and …
Immunohistochemistry and Western blot analyses were used to examine the expression of EZH2 in 40 cases of human cholangiocarcinoma ti …
Bile-based detection of extrahepatic cholangiocarcinoma with quantitative DNA methylation markers and its high sensitivity.
Shin SH, Lee K, Kim BH, Cho NY, Jang JY, Kim YT, Kim D, Jang JJ, Kang GH. Shin SH, et al. J Mol Diagn. 2012 May-Jun;14(3):256-63. doi: 10.1016/j.jmoldx.2012.01.014. Epub 2012 Mar 22. J Mol Diagn. 2012. PMID: 22446083 Free article.
Extrahepatic cholangiocarcinoma (EHC) is usually difficult to diagnose by bile cytology because of cellular disintegration. However, DNA samples from bile fluid can provide sufficient materials to screen for the presence of EHC. ...In an independent test set of bile fluid …
Extrahepatic cholangiocarcinoma (EHC) is usually difficult to diagnose by bile cytology because of cellular disintegration. However, …
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