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Year Number of Results
2004 1
2008 1
2010 3
2011 5
2012 1
2013 1
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2016 2
2017 2
2018 2
2019 3
2020 4
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Association of caspase-9 and RUNX3 with inflammatory bowel disease.
Guo C, Ahmad T, Beckly J, Cummings JR, Hancock L, Geremia A, Cooney R, Pathan S, Jewell DP. Guo C, et al. Tissue Antigens. 2011 Jan;77(1):23-9. doi: 10.1111/j.1399-0039.2010.01569.x. Epub 2010 Sep 30. Tissue Antigens. 2011. PMID: 20887385
Previous linkage studies have identified a region at 1p36 as the susceptibility locus (IBD7) of inflammatory bowel disease (IBD). ...We studied 555 Crohn's disease (CD) and 651 ulcerative colitis (UC) patients recruited from a single UK center. …
Previous linkage studies have identified a region at 1p36 as the susceptibility locus (IBD7) of inflammatory bowel disease
Runx3 prevents spontaneous colitis by directing the differentiation of anti-inflammatory mononuclear phagocytes.
Hantisteanu S, Dicken Y, Negreanu V, Goldenberg D, Brenner O, Leshkowitz D, Lotem J, Levanon D, Groner Y. Hantisteanu S, et al. PLoS One. 2020 May 26;15(5):e0233044. doi: 10.1371/journal.pone.0233044. eCollection 2020. PLoS One. 2020. PMID: 32453801 Free PMC article.
Runx3 deletion in MNP causes early onset colitis due to their impaired maturation. Mechanistically, the resulting MNP subset imbalance leads to up-regulation of pro-inflammatory genes as occurs in IL10R-deficient RM. ...Collectively, Runx3 imposes inte
Runx3 deletion in MNP causes early onset colitis due to their impaired maturation. Mechanistically, the resulting MNP subset i
The study of methylation and single nucleotide polymorphisms of cancer-related genes in patients with early-stage ulcerative colitis.
Chen HX, Yuan ZY, Wu KX, Liu C, Mao QD, He BG, Yuan H. Chen HX, et al. Scand J Gastroenterol. 2019 Apr;54(4):427-431. doi: 10.1080/00365521.2019.1594355. Epub 2019 May 2. Scand J Gastroenterol. 2019. PMID: 31046486
Aim: To investigate the methylation status and single nucleotide polymorphisms (SNPs) of cancer-associated genes in ulcerative colitis (UC) patients and explore the potential mechanism for high cancer risk of UC. ...There was no significant difference in the methylation ra …
Aim: To investigate the methylation status and single nucleotide polymorphisms (SNPs) of cancer-associated genes in ulcerative colitis
Methylation patterns in dysplasia in inflammatory bowel disease patients.
Rosa I, Silva P, da Mata S, Magro F, Carneiro F, Peixoto A, Silva M, Sousa HT, Roseira J, Parra J, Barosa R, Vieira A, Brito MJ, Lago P, Coelho A, Moleiro J, Pereira da Silva J, Fonseca R, Albuquerque C, Dias Pereira A; Grupo de Estudos em Doença Inflamatória Intestinal – GEDII. Rosa I, et al. Scand J Gastroenterol. 2020 Jun;55(6):646-655. doi: 10.1080/00365521.2020.1766552. Epub 2020 May 26. Scand J Gastroenterol. 2020. PMID: 32456486
Background and aims: Inflammatory Bowel Disease (IBD) with colonic involvement increases colorectal cancer risk. However, the distinction between IBD related and sporadic dysplasia in IBD patients is difficult. ...Twenty-ninepatients had ulcerative colitis
Background and aims: Inflammatory Bowel Disease (IBD) with colonic involvement increases colorectal cancer risk. Howeve …
MicroRNA-19b alleviates lipopolysaccharide-induced inflammatory injury in human intestinal cells by up-regulation of Runx3.
Qiao CX, Xu S, Wang DD, Gao SY, Zhao SF, Zhang ML, Yu B, Yin Q, Zhao G. Qiao CX, et al. Eur Rev Med Pharmacol Sci. 2018 Aug;22(16):5284-5294. doi: 10.26355/eurrev_201808_15728. Eur Rev Med Pharmacol Sci. 2018. PMID: 30178853 Free article.
OBJECTIVE: Ulcerative colitis (UC) is an unexplained inflammatory disease in bowel. Some studies reported that microRNA-19b (miR-19b) was closely related to cell inflammatory response. ...In addition, miR-19b regulated the expression of Runx3
OBJECTIVE: Ulcerative colitis (UC) is an unexplained inflammatory disease in bowel. Some studies reported that m …
DNA methylation patterns in ulcerative colitis-associated cancer: a systematic review.
Emmett RA, Davidson KL, Gould NJ, Arasaradnam RP. Emmett RA, et al. Epigenomics. 2017 Jul;9(7):1029-1042. doi: 10.2217/epi-2017-0025. Epub 2017 Jun 16. Epigenomics. 2017. PMID: 28621161 Review.
BACKGROUND: Evidence points to the role of DNA methylation in ulcerative colitis (UC)-associated cancer (UCC), the most serious complication of ulcerative colitis. ...Certain individual genes are, however, highly methylated in colitis-associated cancer: RU
BACKGROUND: Evidence points to the role of DNA methylation in ulcerative colitis (UC)-associated cancer (UCC), the most serious compl …
Validation of epigenetic markers to identify colitis associated cancer: Results of module 1 of the ENDCAP-C study.
Beggs AD, Mehta S, Deeks JJ, James JD, Caldwell GM, Dilworth MP, Stockton JD, Blakeway D, Pestinger V, Vince A, Taniere P, Iqbal T, Magill L, Matthews G, Morton DG; ENDCAP-C Module 1 Collaborative. Beggs AD, et al. EBioMedicine. 2019 Jan;39:265-271. doi: 10.1016/j.ebiom.2018.11.034. Epub 2018 Nov 22. EBioMedicine. 2019. PMID: 30473377 Free PMC article. Clinical Trial.
BACKGROUND: Chronic inflammation caused by ulcerative colitis (UC) causes a pro-neoplastic drive in the inflamed colon, leading to a markedly greater risk of invasive malignancy compared to the general population. ...For non-neoplastic mucosa a four marker panel (APC1A, SF …
BACKGROUND: Chronic inflammation caused by ulcerative colitis (UC) causes a pro-neoplastic drive in the inflamed colon, leading to a …
Myeloperoxidase immunohistochemistry as a measure of disease activity in ulcerative colitis: association with ulcerative colitis-colorectal cancer, tumor necrosis factor polymorphism and RUNX3 methylation.
Garrity-Park M, Loftus EV Jr, Sandborn WJ, Smyrk TC. Garrity-Park M, et al. Inflamm Bowel Dis. 2012 Feb;18(2):275-83. doi: 10.1002/ibd.21681. Epub 2011 Mar 18. Inflamm Bowel Dis. 2012. PMID: 21425209
BACKGROUND: Patients with extensive, longstanding ulcerative colitis (UC), a disease of chronic colonic inflammation, are at risk for colorectal cancer (CRC). ...Increased MPO staining was associated with methylation of RUNX3 and the TNF-α -308G>A SNP. CON …
BACKGROUND: Patients with extensive, longstanding ulcerative colitis (UC), a disease of chronic colonic inflammation, are at r …
Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia.
Brenner O, Levanon D, Negreanu V, Golubkov O, Fainaru O, Woolf E, Groner Y. Brenner O, et al. Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):16016-21. doi: 10.1073/pnas.0407180101. Epub 2004 Oct 28. Proc Natl Acad Sci U S A. 2004. PMID: 15514019 Free PMC article.
RUNX transcription factors are key regulators of lineage-specific gene expression and might be involved in autoimmune diseases. ...Here, we report that at 4 weeks of age, Runx3 knockout (KO) mice spontaneously develop inflammatory bowel disease
RUNX transcription factors are key regulators of lineage-specific gene expression and might be involved in autoimmune diseases. ...He …
Aberrant gene methylation in non-neoplastic mucosa as a predictive marker of ulcerative colitis-associated CRC.
Scarpa M, Scarpa M, Castagliuolo I, Erroi F, Kotsafti A, Basato S, Brun P, D'Incà R, Rugge M, Angriman I, Castoro C. Scarpa M, et al. Oncotarget. 2016 Mar 1;7(9):10322-31. doi: 10.18632/oncotarget.7188. Oncotarget. 2016. PMID: 26862732 Free PMC article.
The number of methylated genes in non-neoplastic colonic mucosa predicted the presence of CRC with good accuracy either in non inflammatory and inflammatory related CRC. METHODS: Colonic mucosal samples were collected from healthy subjects (HC) (n = 30) and from pat …
The number of methylated genes in non-neoplastic colonic mucosa predicted the presence of CRC with good accuracy either in non inflammato
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