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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 1
1957 2
1958 4
1959 6
1960 4
1961 4
1962 7
1963 5
1964 5
1965 7
1966 10
1967 12
1968 6
1969 22
1970 20
1971 83
1972 154
1973 136
1974 159
1975 147
1976 123
1977 138
1978 153
1979 131
1980 159
1981 163
1982 160
1983 182
1984 182
1985 172
1986 173
1987 195
1988 182
1989 168
1990 172
1991 150
1992 176
1993 192
1994 184
1995 184
1996 183
1997 163
1998 181
1999 176
2000 234
2001 239
2002 281
2003 250
2004 251
2005 248
2006 313
2007 302
2008 351
2009 330
2010 374
2011 388
2012 373
2013 424
2014 394
2015 336
2016 377
2017 354
2018 376
2019 380
2020 297
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10,998 results
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Page 1
S-Adenosyl-L-methionine-dependent restriction enzymes.
Sistla S, Rao DN. Sistla S, et al. Crit Rev Biochem Mol Biol. 2004 Jan-Feb;39(1):1-19. doi: 10.1080/10409230490440532. Crit Rev Biochem Mol Biol. 2004. PMID: 15121719 Review.
While the role of S-Adenosyl-L-methionine (AdoMet) as the methyl group donor in the methylation reaction is undisputed, its requirement in DNA cleavage reaction has been subject to intense study. ...
While the role of S-Adenosyl-L-methionine (AdoMet) as the methyl group donor in the methylation reaction is undi …
S-Adenosyl Methionine (SAMe) for Depression in Adults.
Wilson A. Wilson A. Issues Ment Health Nurs. 2019 Aug;40(8):725-726. doi: 10.1080/01612840.2017.1392161. Epub 2019 Jan 11. Issues Ment Health Nurs. 2019. PMID: 30633610 Review. No abstract available.
S-adenosyl-L-methionine: effects on brain bioenergetic status and transverse relaxation time in healthy subjects.
Silveri MM, Parow AM, Villafuerte RA, Damico KE, Goren J, Stoll AL, Cohen BM, Renshaw PF. Silveri MM, et al. Biol Psychiatry. 2003 Oct 15;54(8):833-9. doi: 10.1016/s0006-3223(03)00064-7. Biol Psychiatry. 2003. PMID: 14550683 Clinical Trial.
If these magnetic resonance techniques are sensitive to S-adenosyl-L-methionine induced alterations in neurochemical processes, these methods may be used in cases of clinical depression to elucidate the mechanism underlying the antidepressant effect of …
If these magnetic resonance techniques are sensitive to S-adenosyl-L-methionine induced alterations in neurochem …
S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis.
Guo T, Chang L, Xiao Y, Liu Q. Guo T, et al. PLoS One. 2015 Mar 16;10(3):e0122124. doi: 10.1371/journal.pone.0122124. eCollection 2015. PLoS One. 2015. PMID: 25774783 Free PMC article. Review.
It has been well established that S-adenosyl-L-methionine (SAMe) is the principal methyl donor in methyltransferase reactions and that SAMe supplementation restores hepatic glutathione (GSH) deposits and attenuates liver injury. ...
It has been well established that S-adenosyl-L-methionine (SAMe) is the principal methyl donor in methyltransfer …
S-Adenosyl Methionine in the Therapy of Depression and Other Psychiatric Disorders.
Karas Kuželički N. Karas Kuželički N. Drug Dev Res. 2016 Nov;77(7):346-356. doi: 10.1002/ddr.21345. Epub 2016 Sep 4. Drug Dev Res. 2016. PMID: 27594595 Review.
Preclinical Research S-adenosyl methionine (SAM) is a major methyl donor and as such exerts its influence on CNS function through methylation reactions, such as methylation of several catecholamine moiety-containing neurotransmitters, epigenetic changes throu …
Preclinical Research S-adenosyl methionine (SAM) is a major methyl donor and as such exerts its influence on CNS functi …
S-adenosyl-L-methionine for alcoholic liver diseases.
Rambaldi A, Gluud C. Rambaldi A, et al. Cochrane Database Syst Rev. 2006 Apr 19;(2):CD002235. doi: 10.1002/14651858.CD002235.pub2. Cochrane Database Syst Rev. 2006. PMID: 16625556 Updated. Review.
BACKGROUND: Alcohol is a major cause of liver disease and disrupts methionine and oxidative balances. S-adenosyl-L-methionine (SAMe) acts as a methyl donor for methylation reactions and participates in the synthesis of glutathione, the main cell …
BACKGROUND: Alcohol is a major cause of liver disease and disrupts methionine and oxidative balances. S-adenosyl-L
Neuropharmacology of S-adenosyl-L-methionine.
Baldessarini RJ. Baldessarini RJ. Am J Med. 1987 Nov 20;83(5A):95-103. doi: 10.1016/0002-9343(87)90860-6. Am J Med. 1987. PMID: 3318448 Review.
The metabolite S-adenosyl-L-methionine (SAMe), when prepared as the stable p-toluene-sulfonate complex of its sulfate salt and given parenterally in high doses, appears to have mood-elevating effects in depressed adults. ...
The metabolite S-adenosyl-L-methionine (SAMe), when prepared as the stable p-toluene-sulfonate complex of its su …
S-Adenosyl-L-methionine: beyond the universal methyl group donor.
Roje S. Roje S. Phytochemistry. 2006 Aug;67(15):1686-98. doi: 10.1016/j.phytochem.2006.04.019. Phytochemistry. 2006. PMID: 16766004 Review.
S-Adenosyl-l-methionine (AdoMet or SAM) is a substrate in numerous enzyme-catalyzed reactions. It not only provides methyl groups in many biological methylations, but also acts as the precursor in the biosynthesis of the polyamines spermidine and sperm
S-Adenosyl-l-methionine (AdoMet or SAM) is a substrate in numerous enzyme-catalyzed reactions. It not only provi
Chemoprevention of hepatocarcinogenesis: S-adenosyl-L-methionine.
Pascale RM, Simile MM, De Miglio MR, Feo F. Pascale RM, et al. Alcohol. 2002 Jul;27(3):193-8. doi: 10.1016/s0741-8329(02)00227-6. Alcohol. 2002. PMID: 12163149 Review.
We observed a decrease in S-adenosyl-L-methionine (SAM) content in the liver, associated with DNA hypomethylation in rat liver, during the development of preneoplastic foci, and in neoplastic nodules and hepatocellular carcinomas, induced in diethylnit …
We observed a decrease in S-adenosyl-L-methionine (SAM) content in the liver, associated with DNA hypomethylatio …
S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease.
Hardy ML, Coulter I, Morton SC, Favreau J, Venuturupalli S, Chiappelli F, Rossi F, Orshansky G, Jungvig LK, Roth EA, Suttorp MJ, Shekelle P. Hardy ML, et al. Evid Rep Technol Assess (Summ). 2003 Aug;(64):1-3. Evid Rep Technol Assess (Summ). 2003. PMID: 12899148 Free PMC article. Review. No abstract available.
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