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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
1993 5
1994 33
1995 96
1996 141
1997 156
1998 175
1999 223
2000 250
2001 261
2002 278
2003 346
2004 373
2005 380
2006 386
2007 437
2008 423
2009 456
2010 428
2011 510
2012 550
2013 574
2014 552
2015 584
2016 557
2017 656
2018 622
2019 677
2020 784
2021 96
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9,913 results
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Page 1
STAT1 in cancer: friend or foe?
Zhang Y, Liu Z. Zhang Y, et al. Discov Med. 2017 Aug;24(130):19-29. Discov Med. 2017. PMID: 28950072 Free article. Review.
The role and significance of STAT1 in cancer biology have been studied for a decade. The majority of evidence shows that activating STAT1 plays a tumor suppressor role in cancer cells. ...To explain how STAT1 may mediate its tumor suppressor effects, we discu …
The role and significance of STAT1 in cancer biology have been studied for a decade. The majority of evidence shows that activating …
STAT1 and STAT3 mutations: important lessons for clinical immunologists.
Olbrich P, Freeman AF. Olbrich P, et al. Expert Rev Clin Immunol. 2018 Dec;14(12):1029-1041. doi: 10.1080/1744666X.2018.1531704. Epub 2018 Oct 25. Expert Rev Clin Immunol. 2018. PMID: 30280610 Review.
Expert commentary: The last several years have seen an explosion in the clinical descriptions and pathogenesis knowledge of the diseases caused by GOF and LOF mutations in STAT1 and STAT3. However, harmonization of laboratory testing and follow-up in international cohorts …
Expert commentary: The last several years have seen an explosion in the clinical descriptions and pathogenesis knowledge of the diseases cau …
STAT1 signaling shields T cells from NK cell-mediated cytotoxicity.
Kang YH, Biswas A, Field M, Snapper SB. Kang YH, et al. Nat Commun. 2019 Feb 22;10(1):912. doi: 10.1038/s41467-019-08743-8. Nat Commun. 2019. PMID: 30796216 Free PMC article.
Stat1(-/-) T cells fail to expand and establish colitis in lymphopenic mice. ...Stat1(-/-) mice however have normal CD4(+) T cell numbers as innate STAT1 signaling is required for their elimination. ...
Stat1(-/-) T cells fail to expand and establish colitis in lymphopenic mice. ...Stat1(-/-) mice however have normal CD4(+) T c
STAT1 inhibits T-cell exhaustion and myeloid derived suppressor cell accumulation to promote antitumor immune responses in head and neck squamous cell carcinoma.
Ryan N, Anderson K, Volpedo G, Hamza O, Varikuti S, Satoskar AR, Oghumu S. Ryan N, et al. Int J Cancer. 2020 Mar 15;146(6):1717-1729. doi: 10.1002/ijc.32781. Epub 2019 Nov 29. Int J Cancer. 2020. PMID: 31709529
Metastatic (LY2) and nonmetastatic (B4B8) head and neck squamous cell carcinoma (HNSCC) cell lines were injected into the oral cavity of Stat1 deficient (Stat1(-/-) ) and Stat1 competent (Stat1(+/+) ) mice. Stat1(-/-) mice displayed increased tu …
Metastatic (LY2) and nonmetastatic (B4B8) head and neck squamous cell carcinoma (HNSCC) cell lines were injected into the oral cavity of …
STAT1 Gain-of-Function Mutations Cause High Total STAT1 Levels With Normal Dephosphorylation.
Zimmerman O, Olbrich P, Freeman AF, Rosen LB, Uzel G, Zerbe CS, Rosenzweig SD, Kuehn HS, Holmes KL, Stephany D, Ding L, Sampaio EP, Hsu AP, Holland SM. Zimmerman O, et al. Front Immunol. 2019 Jul 10;10:1433. doi: 10.3389/fimmu.2019.01433. eCollection 2019. Front Immunol. 2019. PMID: 31354696 Free PMC article.
Signal transducer and activator of transcription (STAT1)1 gain of function (GOF) pathogenic variants have been associated with increased levels of phosphorylated STAT1 and STAT1-dependent cellular responses. ...These findings suggest that patients with STA
Signal transducer and activator of transcription (STAT1)1 gain of function (GOF) pathogenic variants have been associated with increa …
Predicting STAT1 as a prognostic marker in patients with solid cancer.
Zhang J, Wang F, Liu F, Xu G. Zhang J, et al. Ther Adv Med Oncol. 2020 May 8;12:1758835920917558. doi: 10.1177/1758835920917558. eCollection 2020. Ther Adv Med Oncol. 2020. PMID: 32426049 Free PMC article.
BACKGROUND: Aberrant activities of signal transducer and activator of transcription 1 (STAT1) have been implicated in cancer development. However, the prognostic value of STAT1 remains unclear. ...Highly expressed STAT1 may predict prognosis in cancer patient …
BACKGROUND: Aberrant activities of signal transducer and activator of transcription 1 (STAT1) have been implicated in cancer developm …
STAT1 and pathogens, not a friendly relationship.
Najjar I, Fagard R. Najjar I, et al. Biochimie. 2010 May;92(5):425-44. doi: 10.1016/j.biochi.2010.02.009. Epub 2010 Feb 13. Biochimie. 2010. PMID: 20159032 Free PMC article. Review.
STAT1 belongs to the STAT family of transcription factors, which comprises seven factors: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. ...STAT1 is, in fact, involved in the response to several cytokines and to growth factors. ...
STAT1 belongs to the STAT family of transcription factors, which comprises seven factors: STAT1, STAT2, STAT3, STAT4, STAT5A,
Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection.
Page C, Goicochea L, Matthews K, Zhang Y, Klover P, Holtzman MJ, Hennighausen L, Frieman M. Page C, et al. J Virol. 2012 Dec;86(24):13334-49. doi: 10.1128/JVI.01689-12. Epub 2012 Sep 26. J Virol. 2012. PMID: 23015710 Free PMC article.
Mice with STAT1 in either monocytes and macrophages (LysM/STAT1) or ciliated lung epithelial cells (FoxJ1/STAT1) deleted were created. Following infection, LysM/STAT1 mice display severe lung pathology, while FoxJ1/STAT1 mice display normal lung …
Mice with STAT1 in either monocytes and macrophages (LysM/STAT1) or ciliated lung epithelial cells (FoxJ1/STAT1) delete …
Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing.
Robertson G, Hirst M, Bainbridge M, Bilenky M, Zhao Y, Zeng T, Euskirchen G, Bernier B, Varhol R, Delaney A, Thiessen N, Griffith OL, He A, Marra M, Snyder M, Jones S. Robertson G, et al. Nat Methods. 2007 Aug;4(8):651-7. doi: 10.1038/nmeth1068. Epub 2007 Jun 11. Nat Methods. 2007. PMID: 17558387
Of the 34 loci known to contain STAT1 interferon-responsive binding sites, ChIP-seq found 24 (71%). ChIP-seq targets were enriched in sequences similar to known STAT1 binding motifs. Comparisons with two ChIP-PCR data sets suggested that ChIP-seq sensitivity was bet …
Of the 34 loci known to contain STAT1 interferon-responsive binding sites, ChIP-seq found 24 (71%). ChIP-seq targets were enriched in …
STAT1 deficiency predisposes to spontaneous otitis media.
Bodmer D, Kern P, Bächinger D, Monge Naldi A, Levano Huaman S. Bodmer D, et al. PLoS One. 2020 Sep 29;15(9):e0239952. doi: 10.1371/journal.pone.0239952. eCollection 2020. PLoS One. 2020. PMID: 32991625 Free PMC article.
STAT1 as a transcription factor regulates the expression of multiple proinflammatory genes. Inflammatory response is one of the common effects of ototoxicity. Our group reported that hair cells of STAT1 knockout (STAT1-KO) mice are less sensitive to ototoxic
STAT1 as a transcription factor regulates the expression of multiple proinflammatory genes. Inflammatory response is one of the commo
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