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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 8
1995 18
1996 26
1997 27
1998 33
1999 38
2000 32
2001 37
2002 39
2003 44
2004 53
2005 50
2006 43
2007 51
2008 40
2009 46
2010 53
2011 54
2012 56
2013 65
2014 59
2015 71
2016 60
2017 93
2018 80
2019 80
2020 99
2021 19
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1,259 results
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A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses.
Michalska A, Blaszczyk K, Wesoly J, Bluyssen HAR. Michalska A, et al. Front Immunol. 2018 May 28;9:1135. doi: 10.3389/fimmu.2018.01135. eCollection 2018. Front Immunol. 2018. PMID: 29892288 Free PMC article. Review.
Interferon (IFN)-I and IFN-II both induce IFN-stimulated gene (ISG) expression through Janus kinase (JAK)-dependent phosphorylation of signal transducer and activator of transcription (STAT) 1 and STAT2. STAT1 homodimers, known as gamma-activated factor (GAF) …
Interferon (IFN)-I and IFN-II both induce IFN-stimulated gene (ISG) expression through Janus kinase (JAK)-dependent phosphorylation of signa …
STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling.
Arimoto KI, Löchte S, Stoner SA, Burkart C, Zhang Y, Miyauchi S, Wilmes S, Fan JB, Heinisch JJ, Li Z, Yan M, Pellegrini S, Colland F, Piehler J, Zhang DE. Arimoto KI, et al. Nat Struct Mol Biol. 2017 Mar;24(3):279-289. doi: 10.1038/nsmb.3378. Epub 2017 Feb 6. Nat Struct Mol Biol. 2017. PMID: 28165510 Free PMC article.
Here, we report that STAT2 is also a previously unrecognized, crucial component of the USP18-mediated negative-feedback control in both human and mouse cells. We found that STAT2 recruits USP18 to the type I IFN receptor subunit IFNAR2 via its constitutive membrane- …
Here, we report that STAT2 is also a previously unrecognized, crucial component of the USP18-mediated negative-feedback control in bo …
Porcine Deltacoronavirus nsp5 Antagonizes Type I Interferon Signaling by Cleaving STAT2.
Zhu X, Wang D, Zhou J, Pan T, Chen J, Yang Y, Lv M, Ye X, Peng G, Fang L, Xiao S. Zhu X, et al. J Virol. 2017 Apr 28;91(10):e00003-17. doi: 10.1128/JVI.00003-17. Print 2017 May 15. J Virol. 2017. PMID: 28250121 Free PMC article.
Detailed analysis showed that nsp5 cleaved signal transducer and activator of transcription 2 (STAT2) but not Janus kinase 1 (JAK1), tyrosine kinase 2 (TYK2), STAT1, and interferon regulatory factor 9 (IRF9), key molecules of the JAK-STAT pathway. ...Here, fo …
Detailed analysis showed that nsp5 cleaved signal transducer and activator of transcription 2 (STAT2) but not Janus kinase 1 ( …
STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection.
Gopal R, Lee B, McHugh KJ, Rich HE, Ramanan K, Mandalapu S, Clay ME, Seger PJ, Enelow RI, Manni ML, Robinson KM, Rangel-Moreno J, Alcorn JF. Gopal R, et al. Front Immunol. 2018 Sep 25;9:2151. doi: 10.3389/fimmu.2018.02151. eCollection 2018. Front Immunol. 2018. PMID: 30337919 Free PMC article.
Influenza-infected STAT2 (-/-) mice had increased morbidity, viral burden, and inflammation when compared to wild-type mice. ...Together, these results suggest that the STAT2 signaling is involved in suppressing macrophage activation and bacterial control during inf …
Influenza-infected STAT2 (-/-) mice had increased morbidity, viral burden, and inflammation when compared to wild-type mice. ...Toget …
Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling.
Grant A, Ponia SS, Tripathi S, Balasubramaniam V, Miorin L, Sourisseau M, Schwarz MC, Sánchez-Seco MP, Evans MJ, Best SM, García-Sastre A. Grant A, et al. Cell Host Microbe. 2016 Jun 8;19(6):882-90. doi: 10.1016/j.chom.2016.05.009. Epub 2016 May 19. Cell Host Microbe. 2016. PMID: 27212660 Free PMC article.
ZIKV NS5 expression resulted in proteasomal degradation of the IFN-regulated transcriptional activator STAT2 from humans, but not mice, which may explain the requirement for IFN deficiency to observe ZIKV-induced disease in mice. ...However, unlike DENV, ZIKV did not requi …
ZIKV NS5 expression resulted in proteasomal degradation of the IFN-regulated transcriptional activator STAT2 from humans, but not mic …
Structural basis for STAT2 suppression by flavivirus NS5.
Wang B, Thurmond S, Zhou K, Sánchez-Aparicio MT, Fang J, Lu J, Gao L, Ren W, Cui Y, Veit EC, Hong H, Evans MJ, O'Leary SE, García-Sastre A, Zhou ZH, Hai R, Song J. Wang B, et al. Nat Struct Mol Biol. 2020 Oct;27(10):875-885. doi: 10.1038/s41594-020-0472-y. Epub 2020 Aug 10. Nat Struct Mol Biol. 2020. PMID: 32778820
Suppressing cellular signal transducers of transcription 2 (STAT2) is a common strategy that viruses use to establish infections, yet the detailed mechanism remains elusive, owing to a lack of structural information about the viral-cellular complex involved. ...Take …
Suppressing cellular signal transducers of transcription 2 (STAT2) is a common strategy that viruses use to establish infectio …
FBXW7-mediated stability regulation of signal transducer and activator of transcription 2 in melanoma formation.
Lee CJ, An HJ, Kim SM, Yoo SM, Park J, Lee GE, Kim WY, Kim DJ, Kang HC, Lee JY, Lee HS, Cho SJ, Cho YY. Lee CJ, et al. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):584-594. doi: 10.1073/pnas.1909879116. Epub 2019 Dec 16. Proc Natl Acad Sci U S A. 2020. PMID: 31843895 Free PMC article.
We found that the interaction of FBXW7 and STAT2 induced STAT2 destabilization via a ubiquitination-mediated proteasomal degradation pathway. Notably, GSK3beta-mediated STAT2 phosphorylation facilitated STAT2-FBXW7 interactions via the DNA binding doma …
We found that the interaction of FBXW7 and STAT2 induced STAT2 destabilization via a ubiquitination-mediated proteasomal degra …
A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription.
Platanitis E, Demiroz D, Schneller A, Fischer K, Capelle C, Hartl M, Gossenreiter T, Müller M, Novatchkova M, Decker T. Platanitis E, et al. Nat Commun. 2019 Jul 2;10(1):2921. doi: 10.1038/s41467-019-10970-y. Nat Commun. 2019. PMID: 31266943 Free PMC article.
Here, we use an integrated transcriptomic and proteomic approach to analyze transcription-factor binding, gene expression and in vivo proximity-dependent labelling of proteins in living cells under homeostatic and interferon (IFN)-induced conditions. We show that in …
Here, we use an integrated transcriptomic and proteomic approach to analyze transcription-factor binding, gene expression and …
Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2.
Duncan CJA, Thompson BJ, Chen R, Rice GI, Gothe F, Young DF, Lovell SC, Shuttleworth VG, Brocklebank V, Corner B, Skelton AJ, Bondet V, Coxhead J, Duffy D, Fourrage C, Livingston JH, Pavaine J, Cheesman E, Bitetti S, Grainger A, Acres M, Innes BA, Mikulasova A, Sun R, Hussain R, Wright R, Wynn R, Zarhrate M, Zeef LAH, Wood K, Hughes SM, Harris CL, Engelhardt KR, Crow YJ, Randall RE, Kavanagh D, Hambleton S, Briggs TA. Duncan CJA, et al. Sci Immunol. 2019 Dec 13;4(42):eaav7501. doi: 10.1126/sciimmunol.aav7501. Sci Immunol. 2019. PMID: 31836668 Free PMC article.
Whole-exome sequencing revealed a shared homozygous missense Arg148Trp variant in STAT2, a transcription factor that functions exclusively downstream of innate IFNs. Cells bearing STAT2(R148W) in homozygosity (but not heterozygosity) were hypersensitiv …
Whole-exome sequencing revealed a shared homozygous missense Arg148Trp variant in STAT2, a transcription factor that fu …
IRF9 and unphosphorylated STAT2 cooperate with NF-kappaB to drive IL6 expression.
Nan J, Wang Y, Yang J, Stark GR. Nan J, et al. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3906-3911. doi: 10.1073/pnas.1714102115. Epub 2018 Mar 26. Proc Natl Acad Sci U S A. 2018. PMID: 29581268 Free PMC article.
U-STAT2 binds tightly to IRF9, the DNA binding subunit of ISGF3, and also to the p65 subunit of NF-kappaB. Therefore, as shown by ChIP analyses, U-STAT2 can bridge the ISRE and kappaB elements in the IL6 promoter. ...
U-STAT2 binds tightly to IRF9, the DNA binding subunit of ISGF3, and also to the p65 subunit of NF-kappaB. Therefore, as shown by ChI …
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