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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 2
1994 3
1995 9
1996 12
1997 19
1998 26
1999 39
2000 50
2001 56
2002 53
2003 56
2004 64
2005 75
2006 62
2007 60
2008 77
2009 85
2010 106
2011 109
2012 82
2013 88
2014 100
2015 101
2016 90
2017 97
2018 89
2019 89
2020 100
2021 9
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1,643 results
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Page 1
Epigenetic control of innate and adaptive immune memory.
Lau CM, Adams NM, Geary CD, Weizman OE, Rapp M, Pritykin Y, Leslie CS, Sun JC. Lau CM, et al. Nat Immunol. 2018 Sep;19(9):963-972. doi: 10.1038/s41590-018-0176-1. Epub 2018 Aug 6. Nat Immunol. 2018. PMID: 30082830 Free PMC article.
Here we demonstrate that differentiating and 'memory' NK cells possess distinct chromatin accessibility states and that their epigenetic profiles reveal a 'poised' regulatory program at the memory stage. Furthermore, we elucidate how individual STAT transcription factors d …
Here we demonstrate that differentiating and 'memory' NK cells possess distinct chromatin accessibility states and that their epigenetic pro …
Unfolding the pathogenesis of scleroderma through genomics and epigenomics.
Tsou PS, Sawalha AH. Tsou PS, et al. J Autoimmun. 2017 Sep;83:73-94. doi: 10.1016/j.jaut.2017.05.004. Epub 2017 May 16. J Autoimmun. 2017. PMID: 28526340 Free PMC article. Review.
Other pathways include genes involved in extracellular matrix deposition, cytokines, and autophagy. Among these genes, IRF5, STAT4, and CD247 were replicated most frequently while SNPs rs35677470 in DNASE1L3, rs5029939 in TNFAIP3, and rs7574685 in STAT4 have the str …
Other pathways include genes involved in extracellular matrix deposition, cytokines, and autophagy. Among these genes, IRF5, STAT4, a …
Pathogenesis and treatment of autoimmune rheumatic diseases.
Liu E, Perl A. Liu E, et al. Curr Opin Rheumatol. 2019 May;31(3):307-315. doi: 10.1097/BOR.0000000000000594. Curr Opin Rheumatol. 2019. PMID: 30920455 Free PMC article. Review.
RECENT FINDINGS: In addition to the long-recognized genetic impact of the HLA locus, interferon regulatory factors, PTPN22, STAT4, and NOX have been implicated in pathogenesis of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). ...
RECENT FINDINGS: In addition to the long-recognized genetic impact of the HLA locus, interferon regulatory factors, PTPN22, STAT4, an …
The IL-12-STAT4 axis in the pathogenesis of human systemic lupus erythematosus.
Ueno H. Ueno H. Eur J Immunol. 2020 Jan;50(1):10-16. doi: 10.1002/eji.201948134. Epub 2019 Dec 3. Eur J Immunol. 2020. PMID: 31762023 Free article. Review.
In this mini-review, the author will first briefly summarize the features of CD11c(+) DN B cells in human SLE, and discuss how the IL-12-STAT4 axis might contribute to the generation of autoantibodies in SLE. ...
In this mini-review, the author will first briefly summarize the features of CD11c(+) DN B cells in human SLE, and discuss how the IL-12- …
NK cells and interferons.
Paolini R, Bernardini G, Molfetta R, Santoni A. Paolini R, et al. Cytokine Growth Factor Rev. 2015 Apr;26(2):113-20. doi: 10.1016/j.cytogfr.2014.11.003. Epub 2014 Nov 13. Cytokine Growth Factor Rev. 2015. PMID: 25443799 Review.
Editorial: Not all roads to T cell memory go through STAT4 and T-bet.
Whitmire JK. Whitmire JK. J Leukoc Biol. 2014 May;95(5):699-701. doi: 10.1189/jlb.1113578. J Leukoc Biol. 2014. PMID: 27929377 No abstract available.
Lkb1 maintains Treg cell lineage identity.
Wu D, Luo Y, Guo W, Niu Q, Xue T, Yang F, Sun X, Chen S, Liu Y, Liu J, Sun Z, Zhao C, Huang H, Liao F, Han Z, Zhou D, Yang Y, Xu G, Cheng T, Feng X. Wu D, et al. Nat Commun. 2017 Jun 16;8:15876. doi: 10.1038/ncomms15876. Nat Commun. 2017. PMID: 28621313 Free PMC article.
Mice with T(reg) cell-specific deletion of Lkb1 develop a fatal early-onset autoimmune disease, with no Foxp3 expression in most T(reg) cells. Lkb1 stabilizes Foxp3 expression by preventing STAT4-mediated methylation of the conserved noncoding sequence 2 (CNS2) in the Foxp …
Mice with T(reg) cell-specific deletion of Lkb1 develop a fatal early-onset autoimmune disease, with no Foxp3 expression in most T(reg) cell …
Interleukin-12: Functional activities and implications for disease.
Zundler S, Neurath MF. Zundler S, et al. Cytokine Growth Factor Rev. 2015 Oct;26(5):559-68. doi: 10.1016/j.cytogfr.2015.07.003. Epub 2015 Jul 4. Cytokine Growth Factor Rev. 2015. PMID: 26182974 Review.
It is a heterodimeric protein of two subunits (p35, p40) secreted by phagocytic cells in response to pathogens and mainly acts through STAT4 to induce IFN-gamma production in T and NK cells. IFN-gamma in turn mediates proinflammatory functions and activates T-bet. ...
It is a heterodimeric protein of two subunits (p35, p40) secreted by phagocytic cells in response to pathogens and mainly acts through ST …
Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast Production of Inflammatory Mediators.
Nguyen HN, Noss EH, Mizoguchi F, Huppertz C, Wei KS, Watts GFM, Brenner MB. Nguyen HN, et al. Immunity. 2017 Feb 21;46(2):220-232. doi: 10.1016/j.immuni.2017.01.004. Immunity. 2017. PMID: 28228280 Free PMC article.
Here, we report that analyses of genes coordinately upregulated with IL-6 pointed to STAT4 and leukemia inhibitory factor (LIF) as potentially linked. Gene silencing revealed that STAT4 was required for IL-6 transcription. STAT4 was recruited to …
Here, we report that analyses of genes coordinately upregulated with IL-6 pointed to STAT4 and leukemia inhibitory factor (LIF …
STAT4 activation by leukemia inhibitory factor confers a therapeutic effect on intestinal inflammation.
Zhang YS, Xin DE, Wang Z, Song X, Sun Y, Zou QC, Yue J, Zhang C, Zhang JM, Liu Z, Zhang X, Zhao TC, Su B, Chin YE. Zhang YS, et al. EMBO J. 2019 Mar 15;38(6):e99595. doi: 10.15252/embj.201899595. Epub 2019 Feb 15. EMBO J. 2019. PMID: 30770344 Free PMC article.
Here, we report that microbiota dysregulation promotes LIF secretion by intestinal epithelial cells (IECs) in a mouse colitis model. LIF greatly activates STAT4 phosphorylation on multiple SPXX elements within the C-terminal transcription regulation domain. ...In la …
Here, we report that microbiota dysregulation promotes LIF secretion by intestinal epithelial cells (IECs) in a mouse colitis model. LIF gre …
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