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Year Number of Results
1948 1
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1953 1
1954 1
1955 1
1964 1
1992 3
1993 2
1994 9
1995 48
1996 97
1997 130
1998 144
1999 201
2000 194
2001 217
2002 225
2003 219
2004 238
2005 248
2006 270
2007 285
2008 301
2009 289
2010 322
2011 352
2012 397
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2018 333
2019 347
2020 340
2021 34
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6,458 results
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Page 1
STAT5 in Cancer and Immunity.
Rani A, Murphy JJ. Rani A, et al. J Interferon Cytokine Res. 2016 Apr;36(4):226-37. doi: 10.1089/jir.2015.0054. Epub 2015 Dec 30. J Interferon Cytokine Res. 2016. PMID: 26716518 Review.
Essentially, STAT5 plays a critical role in the function and development of Tregs, and consistently activated STAT5 is associated with a suppression in antitumor immunity and an increase in proliferation, invasion, and survival of tumor cells. Thus, therapeutic targ …
Essentially, STAT5 plays a critical role in the function and development of Tregs, and consistently activated STAT5 is associa …
STATs in cancer inflammation and immunity: a leading role for STAT3.
Yu H, Pardoll D, Jove R. Yu H, et al. Nat Rev Cancer. 2009 Nov;9(11):798-809. doi: 10.1038/nrc2734. Nat Rev Cancer. 2009. PMID: 19851315 Free PMC article. Review.
Commensurate with their roles in regulating cytokine-dependent inflammation and immunity, signal transducer and activator of transcription (STAT) proteins are central in determining whether immune responses in the tumour microenvironment promote or inhibit cancer. Persiste …
Commensurate with their roles in regulating cytokine-dependent inflammation and immunity, signal transducer and activator of transcriptio …
STAT5 and STAT5 Inhibitors in Hematological Malignancies.
Tolomeo M, Meli M, Grimaudo S. Tolomeo M, et al. Anticancer Agents Med Chem. 2019;19(17):2036-2046. doi: 10.2174/1871520619666190906160848. Anticancer Agents Med Chem. 2019. PMID: 31490767 Review.
This has led many researchers to develop compounds capable of inhibiting STAT5 activation or interfering with its functions. Several anti-STAT5 molecules have shown potent STAT5 inhibitory activity in vitro. ...In this review, we discuss the implication of …
This has led many researchers to develop compounds capable of inhibiting STAT5 activation or interfering with its functions. Several …
Essential roles of stat5.1/stat5b in controlling fish somatic growth.
Xiong S, Mei J, Huang P, Jing J, Li Z, Kang J, Gui JF. Xiong S, et al. J Genet Genomics. 2017 Dec 20;44(12):577-585. doi: 10.1016/j.jgg.2017.07.006. Epub 2017 Nov 16. J Genet Genomics. 2017. PMID: 29246863
However, the corresponding homologue gene of Stat5b is unknown in fish species. In this study, we generated loss-of-function mutants in stat5.1 and stat5.2, two stat5 homologues existing in zebrafish. ...Additionally, we found a novel molecular interaction be …
However, the corresponding homologue gene of Stat5b is unknown in fish species. In this study, we generated loss-of-function mutants in s …
Long non-coding RNA RP11-468E2.5 curtails colorectal cancer cell proliferation and stimulates apoptosis via the JAK/STAT signaling pathway by targeting STAT5 and STAT6.
Jiang L, Zhao XH, Mao YL, Wang JF, Zheng HJ, You QS. Jiang L, et al. J Exp Clin Cancer Res. 2019 Nov 12;38(1):465. doi: 10.1186/s13046-019-1428-0. J Exp Clin Cancer Res. 2019. PMID: 31718693 Free PMC article.
This study aims to examine the effects of lncRNA RP11-468E2.5 and its target genes (STAT5 and STAT6) on the biological activities of CRC cells via the Janus kinase-signal transducer and activator of transcription (JAK/STAT) signaling pathway. ...The treatment of siR …
This study aims to examine the effects of lncRNA RP11-468E2.5 and its target genes (STAT5 and STAT6) on the biological activities of …
JAK of all trades: JAK2-STAT5 as novel therapeutic targets in BCR-ABL1+ chronic myeloid leukemia.
Warsch W, Walz C, Sexl V. Warsch W, et al. Blood. 2013 Sep 26;122(13):2167-75. doi: 10.1182/blood-2013-02-485573. Epub 2013 Aug 7. Blood. 2013. PMID: 23926299 Review.
The transcription factor signal transducers and activators of transcription 5 (STAT5) has an important and unique role in Breakpoint Cluster Region - Abelson 1 (BCR-ABL1)-driven neoplasias. STAT5 is an essential component in the signaling networ …
The transcription factor signal transducers and activators of transcription 5 (STAT5) has an important and uniqu …
Ikaros antagonizes DNA binding by STAT5 in pre-B cells.
Heizmann B, Le Gras S, Simand C, Marchal P, Chan S, Kastner P. Heizmann B, et al. PLoS One. 2020 Nov 12;15(11):e0242211. doi: 10.1371/journal.pone.0242211. eCollection 2020. PLoS One. 2020. PMID: 33180866 Free PMC article.
The IKZF1 gene, which encodes the Ikaros transcription factor, is frequently deleted or mutated in patients with B-cell precursor acute lymphoblastic leukemias that express oncogenes, like BCR-ABL, which activate the JAK-STAT5 pathway. Ikaros functionally ant …
The IKZF1 gene, which encodes the Ikaros transcription factor, is frequently deleted or mutated in patients with B-cell precur …
STAT5-Driven Enhancers Tightly Control Temporal Expression of Mammary-Specific Genes.
Shin HY, Hennighausen L, Yoo KH. Shin HY, et al. J Mammary Gland Biol Neoplasia. 2019 Mar;24(1):61-71. doi: 10.1007/s10911-018-9418-y. Epub 2018 Oct 17. J Mammary Gland Biol Neoplasia. 2019. PMID: 30328555 Review.
The de novo formation of milk-secreting mammary epithelium during pregnancy is regulated by prolactin through activation of the transcription factor STAT5, which stimulates the expression of several hundred mammary-specific genes. ...Integration of data from …
The de novo formation of milk-secreting mammary epithelium during pregnancy is regulated by prolactin through activation of the transcrip …
Brain STAT5 signaling and behavioral control.
Furigo IC, Ramos-Lobo AM, Frazão R, Donato J Jr. Furigo IC, et al. Mol Cell Endocrinol. 2016 Dec 15;438:70-76. doi: 10.1016/j.mce.2016.04.019. Epub 2016 Apr 24. Mol Cell Endocrinol. 2016. PMID: 27118133 Review.
Several growth factors and cytokines recruit the signal transducer and activator of transcription 5 (STAT5) signaling pathway to control cell proliferation, differentiation and apoptosis. Nonetheless, the importance of this transcription factor for bra …
Several growth factors and cytokines recruit the signal transducer and activator of transcription 5 (STAT5) signaling pathway …
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation.
Laurence A, Tato CM, Davidson TS, Kanno Y, Chen Z, Yao Z, Blank RB, Meylan F, Siegel R, Hennighausen L, Shevach EM, O'shea JJ. Laurence A, et al. Immunity. 2007 Mar;26(3):371-81. doi: 10.1016/j.immuni.2007.02.009. Immunity. 2007. PMID: 17363300 Free article.
Whereas STAT3 appeared to be a key positive regulator of RORgammat and IL-17 expression, absence of IL-2 or disruption of its signaling by deletion of the transcription factor STAT5 resulted in enhanced Th17 cell development. ...
Whereas STAT3 appeared to be a key positive regulator of RORgammat and IL-17 expression, absence of IL-2 or disruption of its signaling by d …
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