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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 1
1995 9
1996 30
1997 49
1998 59
1999 69
2000 104
2001 102
2002 123
2003 120
2004 132
2005 151
2006 140
2007 117
2008 124
2009 153
2010 155
2011 185
2012 151
2013 192
2014 187
2015 203
2016 207
2017 224
2018 264
2019 248
2020 285
2021 25
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3,437 results
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STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice.
Cai W, Dai X, Chen J, Zhao J, Xu M, Zhang L, Yang B, Zhang W, Rocha M, Nakao T, Kofler J, Shi Y, Stetler RA, Hu X, Chen J. Cai W, et al. JCI Insight. 2019 Oct 17;4(20):e131355. doi: 10.1172/jci.insight.131355. JCI Insight. 2019. PMID: 31619589 Free PMC article.
Activation of STAT6 was observed in microglia/macrophages in the ischemic territory in a mouse model of stroke and in stroke patients. ...Adoptive transfer of WT macrophages into STAT6-KO mice reduced accumulation of dead neurons in the ischemic territory and amelio …
Activation of STAT6 was observed in microglia/macrophages in the ischemic territory in a mouse model of stroke and in stroke patients …
STAT6 Upregulation Promotes M2 Macrophage Polarization to Suppress Atherosclerosis.
Gong M, Zhuo X, Ma A. Gong M, et al. Med Sci Monit Basic Res. 2017 Jun 15;23:240-249. doi: 10.12659/msmbr.904014. Med Sci Monit Basic Res. 2017. PMID: 28615615 Free PMC article.
The overexpression of STAT6 substantially reversed the ox-LDL-stimulated macrophage apoptosis and lipid accumulation. ...Furthermore, we found that STAT6 overexpression activated the Wnt-beta-catenin signaling by enhancing the translocation of beta-catenin, while be …
The overexpression of STAT6 substantially reversed the ox-LDL-stimulated macrophage apoptosis and lipid accumulation. ...Furthermore, …
Analysis of IL-4/STAT6 Signaling in Macrophages.
Waqas SFH, Ampem G, Röszer T. Waqas SFH, et al. Methods Mol Biol. 2019;1966:211-224. doi: 10.1007/978-1-4939-9195-2_17. Methods Mol Biol. 2019. PMID: 31041750
Interleukin (IL)-4 and IL-13 are important M2 polarizing cytokines that act through STAT6 by inducing its phosphorylation and promoting transcription of STAT6-responsive genes. Inactivation of STAT6 signaling in macrophages has not been fully explored; howeve …
Interleukin (IL)-4 and IL-13 are important M2 polarizing cytokines that act through STAT6 by inducing its phosphorylation and promoti …
Non-hematopoietic STAT6 induces epithelial tight junction dysfunction and promotes intestinal inflammation and tumorigenesis.
Lin Y, Li B, Yang X, Liu T, Shi T, Deng B, Zhang Y, Jia L, Jiang Z, He R. Lin Y, et al. Mucosal Immunol. 2019 Nov;12(6):1304-1315. doi: 10.1038/s41385-019-0204-y. Epub 2019 Sep 18. Mucosal Immunol. 2019. PMID: 31534167
Here, we demonstrated that non-hematopoietic STAT6, but not hematopoietic STAT6, triggered DSS-induced colitis and subsequent tumorigenesis. ...Importantly, pharmacological inhibition of STAT6 reduces murine intestinal tumor formation, and tumoral p-STAT6 …
Here, we demonstrated that non-hematopoietic STAT6, but not hematopoietic STAT6, triggered DSS-induced colitis and subsequent …
Activation of the IL-4/STAT6 Signaling Pathway Promotes Lung Cancer Progression by Increasing M2 Myeloid Cells.
Fu C, Jiang L, Hao S, Liu Z, Ding S, Zhang W, Yang X, Li S. Fu C, et al. Front Immunol. 2019 Nov 13;10:2638. doi: 10.3389/fimmu.2019.02638. eCollection 2019. Front Immunol. 2019. PMID: 31798581 Free PMC article.
This study aimed to investigate the role of STAT6 and the interaction between STAT6 and the tumor microenvironment in pulmonary tumorigenesis. We established a murine model of primary lung carcinogenesis in STAT6-deficient (STAT6(-/-)) and STAT6 …
This study aimed to investigate the role of STAT6 and the interaction between STAT6 and the tumor microenvironment in pulmonar …
Activation of STAT6 by STING is critical for antiviral innate immunity.
Chen H, Sun H, You F, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y, Xia W, Gu J, Ishikawa H, Gutman D, Barber G, Qin Z, Jiang Z. Chen H, et al. Cell. 2011 Oct 14;147(2):436-46. doi: 10.1016/j.cell.2011.09.022. Cell. 2011. PMID: 22000020 Free article.
Viruses or cytoplasmic nucleic acids trigger STING (also named MITA/ERIS) to recruit STAT6 to the endoplasmic reticulum, leading to STAT6 phosphorylation on Ser(407) by TBK1 and Tyr(641), independent of JAKs. ...Virus-induced STAT6 activation is detected in a …
Viruses or cytoplasmic nucleic acids trigger STING (also named MITA/ERIS) to recruit STAT6 to the endoplasmic reticulum, leading to …
STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI.
Olde Heuvel F, Holl S, Chandrasekar A, Li Z, Wang Y, Rehman R, Förstner P, Sinske D, Palmer A, Wiesner D, Ludolph A, Huber-Lang M, Relja B, Wirth T, Röszer T, Baumann B, Boeckers T, Knöll B, Roselli F. Olde Heuvel F, et al. Brain Behav Immun. 2019 Oct;81:228-246. doi: 10.1016/j.bbi.2019.06.019. Epub 2019 Jun 15. Brain Behav Immun. 2019. PMID: 31207335
We showed that TBI causes the elevation of IL-33, IL-1beta, IL-38, TNF-alpha, IFN-alpha, IL-19 in the hippocampus at 3 h time point and concomitant EI results in the dose-dependent downregulation of IL-33, IL-1beta, IL-38, TNF-alpha and IL-19 (but not of IFN-alpha) and in the sel …
We showed that TBI causes the elevation of IL-33, IL-1beta, IL-38, TNF-alpha, IFN-alpha, IL-19 in the hippocampus at 3 h time point and conc …
Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics.
Doyle LA, Vivero M, Fletcher CD, Mertens F, Hornick JL. Doyle LA, et al. Mod Pathol. 2014 Mar;27(3):390-5. doi: 10.1038/modpathol.2013.164. Epub 2013 Sep 13. Mod Pathol. 2014. PMID: 24030747
Fifty-nine of 60 SFT cases (98%) showed nuclear expression of STAT6, which was usually diffuse and intense. All other tumor types were negative for STAT6, except for three dedifferentiated liposarcomas and one deep fibrous histiocytoma, which showed weak staining. I …
Fifty-nine of 60 SFT cases (98%) showed nuclear expression of STAT6, which was usually diffuse and intense. All other tumor types wer …
T-bet and STAT6 Coordinately Suppress the Development of IL-9-Mediated Atopic Dermatitis-Like Skin Inflammation in Mice.
Makita S, Takatori H, Matsuki A, Kawashima H, Iwata A, Tanaka S, Nakagomi D, Oya Y, Matsumura R, Tamachi T, Suto A, Suzuki K, Hirose K, Nakajima H. Makita S, et al. J Invest Dermatol. 2020 Oct 14:S0022-202X(20)32169-2. doi: 10.1016/j.jid.2020.08.029. Online ahead of print. J Invest Dermatol. 2020. PMID: 33068596
However, precise mechanisms of the reciprocal regulation between T-bet and STAT6 in allergy remain unclear. To determine the reciprocal regulation in vivo, we investigated the phenotype of T-bet/STAT6 double-deficient (T-bet(-/-) STAT6(-/-)) mice. Unexpectedl …
However, precise mechanisms of the reciprocal regulation between T-bet and STAT6 in allergy remain unclear. To determine the reciproc …
STAT6 transcription factor is a facilitator of the nuclear receptor PPARgamma-regulated gene expression in macrophages and dendritic cells.
Szanto A, Balint BL, Nagy ZS, Barta E, Dezso B, Pap A, Szeles L, Poliska S, Oros M, Evans RM, Barak Y, Schwabe J, Nagy L. Szanto A, et al. Immunity. 2010 Nov 24;33(5):699-712. doi: 10.1016/j.immuni.2010.11.009. Immunity. 2010. PMID: 21093321 Free PMC article.
Furthermore, IL-4 signaling augmented PPARgamma activity through an interaction between PPARgamma and signal transducer and activators of transcription 6 (STAT6) on promoters of PPARgamma target genes, including FABP4. Thus, STAT6 acts as a facilitating factor for P …
Furthermore, IL-4 signaling augmented PPARgamma activity through an interaction between PPARgamma and signal transducer and activators of tr …
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