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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1972 1
1981 1
1983 1
1987 1
1997 1
2000 3
2001 7
2002 30
2003 41
2004 69
2005 95
2006 115
2007 126
2008 128
2009 179
2010 170
2011 190
2012 198
2013 229
2014 260
2015 260
2016 266
2017 265
2018 267
2019 264
2020 234
2021 20
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3,045 results
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The evolving role of T-bet in resistance to infection.
Pritchard GH, Kedl RM, Hunter CA. Pritchard GH, et al. Nat Rev Immunol. 2019 Jun;19(6):398-410. doi: 10.1038/s41577-019-0145-4. Nat Rev Immunol. 2019. PMID: 30846856 Free PMC article. Review.
The identification of T-bet as a key transcription factor associated with the development of IFNgamma-producing CD4(+) T cells predicted a crucial role for T-bet in cell-mediated immunity and in resistance to many intracellular infections. ...Th …
The identification of T-bet as a key transcription factor associated with the development of IFNgamma-producing CD4(+) T …
T-bet(+) memory B cells: Generation, function, and fate.
Knox JJ, Myles A, Cancro MP. Knox JJ, et al. Immunol Rev. 2019 Mar;288(1):149-160. doi: 10.1111/imr.12736. Immunol Rev. 2019. PMID: 30874358 Free PMC article. Review.
B cells expressing the transcription factor T-bet have emerged as participants in a number of protective and pathogenic immune responses. ...Despite recent advances, a number of questions remain regarding the basic biology of T-bet(+) B cells and their …
B cells expressing the transcription factor T-bet have emerged as participants in a number of protective and pathogenic immune …
Stability and function of regulatory T cells expressing the transcription factor T-bet.
Levine AG, Mendoza A, Hemmers S, Moltedo B, Niec RE, Schizas M, Hoyos BE, Putintseva EV, Chaudhry A, Dikiy S, Fujisawa S, Chudakov DM, Treuting PM, Rudensky AY. Levine AG, et al. Nature. 2017 Jun 15;546(7658):421-425. doi: 10.1038/nature22360. Epub 2017 Jun 7. Nature. 2017. PMID: 28607488 Free PMC article.
Loss of function or elimination of T-bet-expressing T(reg) cells-but not of T-bet expression in T(reg) cells-resulted in severe T(H)1 autoimmunity. Conversely, following depletion of T-bet(-) T(reg) cells, the …
Loss of function or elimination of T-bet-expressing T(reg) cells-but not of T-bet expression in T( …
T-bet and Eomes govern differentiation and function of mouse and human NK cells and ILC1.
Zhang J, Marotel M, Fauteux-Daniel S, Mathieu AL, Viel S, Marçais A, Walzer T. Zhang J, et al. Eur J Immunol. 2018 May;48(5):738-750. doi: 10.1002/eji.201747299. Epub 2018 Feb 28. Eur J Immunol. 2018. PMID: 29424438 Free article. Review.
T-bet and Eomes are T-box transcription factors that drive the differentiation and function of cytotoxic lymphocytes such as NK cells. ...Considering divergent findings on mouse and human ILC1s, we propose that NK cells are defined by coexpression of T …
T-bet and Eomes are T-box transcription factors that drive the differentiation and function of cytotoxic lymphocytes su …
A novel transcription factor, T-bet, directs Th1 lineage commitment.
Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. Szabo SJ, et al. Cell. 2000 Mar 17;100(6):655-69. doi: 10.1016/s0092-8674(00)80702-3. Cell. 2000. PMID: 10761931 Free article.
Here, we report the isolation of T-bet, a Th1-specific T box transcription factor that controls the expression of the hallmark Th1 cytokine, IFNgamma. T-bet expression correlates with IFNgamma expression in Th1 and NK cells. ...
Here, we report the isolation of T-bet, a Th1-specific T box transcription factor that controls the expression of the h …
T-bet: a bridge between innate and adaptive immunity.
Lazarevic V, Glimcher LH, Lord GM. Lazarevic V, et al. Nat Rev Immunol. 2013 Nov;13(11):777-89. doi: 10.1038/nri3536. Epub 2013 Oct 11. Nat Rev Immunol. 2013. PMID: 24113868 Free PMC article. Review.
Originally described over a decade ago as a T cell transcription factor regulating T helper 1 cell lineage commitment, T-bet is now recognized as having an important role in many cells of the adaptive and innate immune system. ...Many of these transcri …
Originally described over a decade ago as a T cell transcription factor regulating T helper 1 cell lineage commitment, T …
T-bet-dependent NKp46(+) innate lymphoid cells regulate the onset of T(H)17-induced neuroinflammation.
Kwong B, Rua R, Gao Y, Flickinger J Jr, Wang Y, Kruhlak MJ, Zhu J, Vivier E, McGavern DB, Lazarevic V. Kwong B, et al. Nat Immunol. 2017 Oct;18(10):1117-1127. doi: 10.1038/ni.3816. Epub 2017 Aug 14. Nat Immunol. 2017. PMID: 28805812 Free PMC article.
The transcription factor T-bet has been associated with increased susceptibility to systemic and organ-specific autoimmunity, but the mechanism by which T-bet expression promotes neuroinflammation remains unknown. In this study, we demonstrate a cardin …
The transcription factor T-bet has been associated with increased susceptibility to systemic and organ-specific autoimmunity, …
The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans.
Johnson JL, Rosenthal RL, Knox JJ, Myles A, Naradikian MS, Madej J, Kostiv M, Rosenfeld AM, Meng W, Christensen SR, Hensley SE, Yewdell J, Canaday DH, Zhu J, McDermott AB, Dori Y, Itkin M, Wherry EJ, Pardi N, Weissman D, Naji A, Prak ETL, Betts MR, Cancro MP. Johnson JL, et al. Immunity. 2020 May 19;52(5):842-855.e6. doi: 10.1016/j.immuni.2020.03.020. Epub 2020 Apr 29. Immunity. 2020. PMID: 32353250
In mice, both T-bet(-) and T-bet(+) hemagglutinin (HA)-specific B cells arose in germinal centers, acquired memory B cell markers, and persisted indefinitely. ...T-bet(+) MBCs could be subdivided into recirculating T-bet(lo) …
In mice, both T-bet(-) and T-bet(+) hemagglutinin (HA)-specific B cells arose in germinal centers, acquired memo …
A T-bet gradient controls the fate and function of CCR6-RORgammat+ innate lymphoid cells.
Klose CS, Kiss EA, Schwierzeck V, Ebert K, Hoyler T, d'Hargues Y, Göppert N, Croxford AL, Waisman A, Tanriver Y, Diefenbach A. Klose CS, et al. Nature. 2013 Feb 14;494(7436):261-5. doi: 10.1038/nature11813. Epub 2013 Jan 16. Nature. 2013. PMID: 23334414
Postnatally emerging CCR6(-)RORgammat(+) ILCs upregulated T-bet and this was controlled by cues from the commensal microbiota and interleukin-23 (IL-23). In contrast, CCR6(+)RORgammat(+) ILCs, which arise earlier during ontogeny, did not express T-bet. …
Postnatally emerging CCR6(-)RORgammat(+) ILCs upregulated T-bet and this was controlled by cues from the commensal microbiota …
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.
Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, Urdahl KB, Campbell DJ. Koch MA, et al. Nat Immunol. 2009 Jun;10(6):595-602. doi: 10.1038/ni.1731. Epub 2009 May 3. Nat Immunol. 2009. PMID: 19412181 Free PMC article.
T-bet promoted expression of the chemokine receptor CXCR3 on T(reg) cells, and T-bet(+) T(reg) cells accumulated at sites of T(H)1 cell-mediated inflammation. Furthermore, T-bet expression was required for the homeost …
T-bet promoted expression of the chemokine receptor CXCR3 on T(reg) cells, and T-bet(+) T(reg) cel …
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