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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2005 1
2006 8
2007 6
2008 7
2009 17
2010 36
2011 28
2012 36
2013 71
2014 59
2015 74
2016 80
2017 111
2018 105
2019 108
2020 87
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736 results
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Bile Acid Physiology.
Di Ciaula A, Garruti G, Lunardi Baccetto R, Molina-Molina E, Bonfrate L, Wang DQ, Portincasa P. Di Ciaula A, et al. Ann Hepatol. 2017 Nov;16(Suppl. 1: s3-105.):s4-s14. doi: 10.5604/01.3001.0010.5493. Ann Hepatol. 2017. PMID: 29080336 Free article. Review.
BAs in the intestine not only regulate the digestion and absorption of cholesterol, triglycerides, and fat-soluble vitamins, but also play a key role as signaling molecules in modulating epithelial cell proliferation, gene expression, and lipid and glucose metabolism by activatin …
BAs in the intestine not only regulate the digestion and absorption of cholesterol, triglycerides, and fat-soluble vitamins, but also play a …
Bile Acid-Activated Receptors: GPBAR1 (TGR5) and Other G Protein-Coupled Receptors.
Keitel V, Stindt J, Häussinger D. Keitel V, et al. Handb Exp Pharmacol. 2019;256:19-49. doi: 10.1007/164_2019_230. Handb Exp Pharmacol. 2019. PMID: 31302759 Review.
The BA-responsive GPCRs S1PR2 and TGR5 are almost ubiquitously expressed in human and rodent tissues. In the liver, S1PR2 is expressed in all cell types, while TGR5 is predominately found in non-parenchymal cells. In contrast to S1PR2, which is mainly activated by c …
The BA-responsive GPCRs S1PR2 and TGR5 are almost ubiquitously expressed in human and rodent tissues. In the liver, S1PR2 is expresse …
Differential effects of FXR or TGR5 activation in cholangiocarcinoma progression.
Erice O, Labiano I, Arbelaiz A, Santos-Laso A, Munoz-Garrido P, Jimenez-Agüero R, Olaizola P, Caro-Maldonado A, Martín-Martín N, Carracedo A, Lozano E, Marin JJ, O'Rourke CJ, Andersen JB, Llop J, Gómez-Vallejo V, Padro D, Martin A, Marzioni M, Adorini L, Trauner M, Bujanda L, Perugorria MJ, Banales JM. Erice O, et al. Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1335-1344. doi: 10.1016/j.bbadis.2017.08.016. Epub 2017 Sep 13. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 28916388 Free article.
Here, the role of bile acid receptors FXR and TGR5 in CCA progression was evaluated. METHODS: FXR and TGR5 expression was determined in human CCA tissues and cell lines. ...FXR expression correlated with tumor differentiation and TGR5 correlated with perineur …
Here, the role of bile acid receptors FXR and TGR5 in CCA progression was evaluated. METHODS: FXR and TGR5 expression was dete …
Role of TGR5 (GPBAR1) in Liver Disease.
Keitel V, Häussinger D. Keitel V, et al. Semin Liver Dis. 2018 Nov;38(4):333-339. doi: 10.1055/s-0038-1669940. Epub 2018 Oct 24. Semin Liver Dis. 2018. PMID: 30357770 Review.
TGR5 (GPBAR1) is a G protein-coupled receptor activated by primary and secondary bile acids, which is expressed in different nonparenchymal cells of the liver, such as sinusoidal endothelial cells, Kupffer cells, cholangiocytes as well as activated hepatic stellate
TGR5 (GPBAR1) is a G protein-coupled receptor activated by primary and secondary bile acids, which is expressed in different n
Bile acid receptors in the biliary tree: TGR5 in physiology and disease.
Deutschmann K, Reich M, Klindt C, Dröge C, Spomer L, Häussinger D, Keitel V. Deutschmann K, et al. Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1319-1325. doi: 10.1016/j.bbadis.2017.08.021. Epub 2017 Aug 25. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 28844960 Free article. Review.
In line with the important role of TGR5 for bile salt signalling, TGR5 knockout mice are more susceptible to cholestatic liver damage. ...Not only the stimulation of TGR5-mediated pathways by suitable TGR5 agonists but also the inhibition of TGR5
In line with the important role of TGR5 for bile salt signalling, TGR5 knockout mice are more susceptible to cholestatic liver …
Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease.
Chávez-Talavera O, Tailleux A, Lefebvre P, Staels B. Chávez-Talavera O, et al. Gastroenterology. 2017 May;152(7):1679-1694.e3. doi: 10.1053/j.gastro.2017.01.055. Epub 2017 Feb 15. Gastroenterology. 2017. PMID: 28214524 Free article. Review.
Bile acids are signaling molecules that coordinately regulate metabolism and inflammation via the nuclear farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 (TGR5). ...
Bile acids are signaling molecules that coordinately regulate metabolism and inflammation via the nuclear farnesoid X receptor (FXR) and the …
TGR5, Not Only a Metabolic Regulator.
Guo C, Chen WD, Wang YD. Guo C, et al. Front Physiol. 2016 Dec 26;7:646. doi: 10.3389/fphys.2016.00646. eCollection 2016. Front Physiol. 2016. PMID: 28082913 Free PMC article. Review.
G-protein-coupled bile acid receptor, Gpbar1 (TGR5), is a member of G-protein-coupled receptor (GPCR) superfamily. High levels of TGR5 mRNA were detected in several tissues such as small intestine, stomach, liver, lung, especially in placenta and spleen. ...T …
G-protein-coupled bile acid receptor, Gpbar1 (TGR5), is a member of G-protein-coupled receptor (GPCR) superfamily. High levels …
Neural processing of itch.
Akiyama T, Carstens E. Akiyama T, et al. Neuroscience. 2013 Oct 10;250:697-714. doi: 10.1016/j.neuroscience.2013.07.035. Epub 2013 Jul 24. Neuroscience. 2013. PMID: 23891755 Free PMC article. Review.
Bile Acids Activated Receptors Regulate Innate Immunity.
Fiorucci S, Biagioli M, Zampella A, Distrutti E. Fiorucci S, et al. Front Immunol. 2018 Aug 13;9:1853. doi: 10.3389/fimmu.2018.01853. eCollection 2018. Front Immunol. 2018. PMID: 30150987 Free PMC article. Review.
Once known exclusively for their role in nutrients absorption, primary bile acids, chenodeoxycholic and cholic acid, and secondary bile acids, deoxycholic and lithocholic acid, are signaling molecules, generated from cholesterol breakdown by the interaction of the host and intest …
Once known exclusively for their role in nutrients absorption, primary bile acids, chenodeoxycholic and cholic acid, and secondary bile acid …
FXR and TGR5 Agonists Ameliorate Liver Injury, Steatosis, and Inflammation After Binge or Prolonged Alcohol Feeding in Mice.
Iracheta-Vellve A, Calenda CD, Petrasek J, Ambade A, Kodys K, Adorini L, Szabo G. Iracheta-Vellve A, et al. Hepatol Commun. 2018 Oct 15;2(11):1379-1391. doi: 10.1002/hep4.1256. eCollection 2018 Nov. Hepatol Commun. 2018. PMID: 30411084 Free PMC article.
Bile acids (BAs) activate various dedicated receptors, including the farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 (TGR5). ...We hypothesized that FXR and/or TGR5 agonists may be therapeutic in early alcoholic liver disease (ALD) in mice, in …
Bile acids (BAs) activate various dedicated receptors, including the farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 …
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