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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2006 1
2007 13
2008 33
2009 52
2010 49
2011 74
2012 90
2013 98
2014 110
2015 109
2016 135
2017 135
2018 149
2019 158
2020 151
2021 38
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1,217 results
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MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.
Wu R, Zeng J, Yuan J, Deng X, Huang Y, Chen L, Zhang P, Feng H, Liu Z, Wang Z, Gao X, Wu H, Wang H, Su Y, Zhao M, Lu Q. Wu R, et al. J Clin Invest. 2018 Jun 1;128(6):2551-2568. doi: 10.1172/JCI97426. Epub 2018 May 14. J Clin Invest. 2018. PMID: 29757188 Free PMC article.
Immune imbalance of T lymphocyte subsets is a hallmark of psoriasis, but the molecular mechanisms underlying this aspect of psoriasis pathology are poorly understood. ...Both miR-210 ablation in mice and inhibition of miR-210 by intradermal injection of antagomir-21 …
Immune imbalance of T lymphocyte subsets is a hallmark of psoriasis, but the molecular mechanisms underlying this aspect of psoria …
The Immunologic Role of IL-17 in Psoriasis and Psoriatic Arthritis Pathogenesis.
Blauvelt A, Chiricozzi A. Blauvelt A, et al. Clin Rev Allergy Immunol. 2018 Dec;55(3):379-390. doi: 10.1007/s12016-018-8702-3. Clin Rev Allergy Immunol. 2018. PMID: 30109481 Free PMC article. Review.
Psoriasis is a chronic, immune-mediated, inflammatory disease that is pathogenically driven by proinflammatory cytokines. This article reviews the immunologic role of interleukin (IL)-17, the major effector cytokine in the pathogenesis of psoriatic disease, along with the …
Psoriasis is a chronic, immune-mediated, inflammatory disease that is pathogenically driven by proinflammatory cytokines. This articl …
Evaluation of the Th17 pathway in psoriasis and geographic tongue.
Picciani BLS, Domingos TA, Teixeira-Souza T, Fausto-Silva AK, Dias EP, Carneiro S. Picciani BLS, et al. An Bras Dermatol. 2019 Nov-Dec;94(6):677-683. doi: 10.1016/j.abd.2019.01.006. Epub 2019 Oct 24. An Bras Dermatol. 2019. PMID: 31789253 Free PMC article.
It has been suggested that the disease is immune-mediated by T-lymphocytes, predominantly Th17 cells. Similar to psoriasis, geographic tongue is an inflammatory disease with participation of Th17 cells and direct correlation with psoriasis …
It has been suggested that the disease is immune-mediated by T-lymphocytes, predominantly Th17 cells. Similar to psoriasis …
Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization.
Chang HW, Yan D, Singh R, Liu J, Lu X, Ucmak D, Lee K, Afifi L, Fadrosh D, Leech J, Vasquez KS, Lowe MM, Rosenblum MD, Scharschmidt TC, Lynch SV, Liao W. Chang HW, et al. Microbiome. 2018 Sep 5;6(1):154. doi: 10.1186/s40168-018-0533-1. Microbiome. 2018. PMID: 30185226 Free PMC article.
BACKGROUND: Psoriasis impacts 1-3% of the world's population and is characterized by hyper-proliferation of keratinocytes and increased inflammation. At the molecular level, psoriasis is commonly driven by a Th17 response, which serves as a major therapeutic …
BACKGROUND: Psoriasis impacts 1-3% of the world's population and is characterized by hyper-proliferation of keratinocytes and increas …
Th17 Cells and the IL-23/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases.
Bunte K, Beikler T. Bunte K, et al. Int J Mol Sci. 2019 Jul 10;20(14):3394. doi: 10.3390/ijms20143394. Int J Mol Sci. 2019. PMID: 31295952 Free PMC article. Review.
In addition, Th17 cells, their key cytokine IL-17, and IL-23 seem to play pivotal roles. This review aims to provide an overview of the current knowledge about the differentiation of Th17 cells and the role of the IL-17/IL-23 axis in the pathogenesis o …
In addition, Th17 cells, their key cytokine IL-17, and IL-23 seem to play pivotal roles. This review aims to provide an overvi …
Update on the pathophysiology of psoriasis.
Hugh JM, Weinberg JM. Hugh JM, et al. Cutis. 2018 Nov;102(5S):6-12. Cutis. 2018. PMID: 30566550 Review.
Psoriasis is a genetically programmed pathologic interaction among skin cells, immunocytes, and numerous biologic signaling molecules that is triggered by environmental stimuli. The immune response is a cellular one; type 1 (TH1) and type 17 (TH17) T cells …
Psoriasis is a genetically programmed pathologic interaction among skin cells, immunocytes, and numerous biologic signaling mo …
Treatment of psoriasis: janus kinases inhibitors and biologics for the interleukin-23/Th17 axis.
Sun C, Xia J. Sun C, et al. Minerva Med. 2020 Jun;111(3):254-265. doi: 10.23736/S0026-4806.20.06460-5. Epub 2020 Mar 12. Minerva Med. 2020. PMID: 32166932 Review.
With the discovery of the IL-23 / Th17 axis, the treatment of psoriasis has entered a new era. The aim of this study was to explore the progress of biologics and janus kinases (JAK) inhibitors targeting IL-23/Th17 axis in the treatment of psoriasis. re …
With the discovery of the IL-23 / Th17 axis, the treatment of psoriasis has entered a new era. The aim of this study was to ex …
Targeting IL-17 and TH17 cells in chronic inflammation.
Miossec P, Kolls JK. Miossec P, et al. Nat Rev Drug Discov. 2012 Oct;11(10):763-76. doi: 10.1038/nrd3794. Nat Rev Drug Discov. 2012. PMID: 23023676 Review.
The key role of interleukin-17 (IL-17) and T helper 17 (T(H)17) cells in tissue inflammation, autoimmunity and host defence led to the experimental targeting of these molecules in mouse models of diseases as well as in clinical settings. Moreover, the demonstration that IL …
The key role of interleukin-17 (IL-17) and T helper 17 (T(H)17) cells in tissue inflammation, autoimmunity and host defence led to th …
Anti IL-17 in psoriasis.
Ly K, Smith MP, Thibodeaux Q, Reddy V, Liao W, Bhutani T. Ly K, et al. Expert Rev Clin Immunol. 2019 Nov;15(11):1185-1194. doi: 10.1080/1744666X.2020.1679625. Epub 2019 Oct 16. Expert Rev Clin Immunol. 2019. PMID: 31603358 Review.
Introduction: Psoriasis is a chronic, immune-mediated disease with significant associated comorbidities. ...The efficacy of IL-17 inhibitors in the treatment of moderate-to-severe psoriasis underscores the importance of the IL-23/Th17 pathway in the pathogene …
Introduction: Psoriasis is a chronic, immune-mediated disease with significant associated comorbidities. ...The efficacy of IL-17 inh …
Thrombospondin-1/CD47 Interaction Regulates Th17 and Treg Differentiation in Psoriasis.
Rodríguez-Jiménez P, Chicharro P, Llamas-Velasco M, Cibrian D, Trigo-Torres L, Vara A, Jiménez-Fernández M, Sevilla-Montero J, Calzada MJ, Sánchez-Madrid F, de la Fuente H, Daudén E. Rodríguez-Jiménez P, et al. Front Immunol. 2019 Jun 4;10:1268. doi: 10.3389/fimmu.2019.01268. eCollection 2019. Front Immunol. 2019. PMID: 31214201 Free PMC article.
Expression of these molecules was also evaluated in peripheral blood CD4+ T cells, moDCs, and circulating primary DCs. The functional role of TSP-1/CD47 signaling axis in psoriasis was assessed in Th17 and Treg differentiation assays. ...Furthermore, exogenou …
Expression of these molecules was also evaluated in peripheral blood CD4+ T cells, moDCs, and circulating primary DCs. The functional …
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