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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 1
1969 1
1970 1
1971 1
1975 1
1976 2
1977 3
1978 4
1979 9
1980 7
1981 5
1982 8
1983 6
1984 5
1985 7
1986 10
1987 13
1988 31
1989 51
1990 70
1991 119
1992 153
1993 258
1994 404
1995 616
1996 755
1997 962
1998 1131
1999 1301
2000 1389
2001 1488
2002 1524
2003 1639
2004 1691
2005 1806
2006 1857
2007 1793
2008 1925
2009 1938
2010 2027
2011 2160
2012 2041
2013 2117
2014 2139
2015 2113
2016 2038
2017 2066
2018 2036
2019 1967
2020 2039
2021 208
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41,999 results
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Page 1
Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease.
Kidd P. Kidd P. Altern Med Rev. 2003 Aug;8(3):223-46. Altern Med Rev. 2003. PMID: 12946237 Free article. Review.
One theory of immune regulation involves homeostasis between T-helper 1 (Th1) and T-helper 2 (Th2) activity. The Th1/Th2 hypothesis arose from 1986 research suggesting mouse T-helper cells expressed differing cytokine patterns. ...Many diseases previously classified …
One theory of immune regulation involves homeostasis between T-helper 1 (Th1) and T-helper 2 (Th2) activity. The Th1/Th2 hypot …
The Metabolic Requirements of Th2 Cell Differentiation.
Stark JM, Tibbitt CA, Coquet JM. Stark JM, et al. Front Immunol. 2019 Sep 27;10:2318. doi: 10.3389/fimmu.2019.02318. eCollection 2019. Front Immunol. 2019. PMID: 31611881 Free PMC article. Review.
The differentiation of Th2 cells is dependent on transcription factors such as GATA3 and STAT6, which prime Th2 cells for the secretion of interleukin- (IL-) 4, IL-5, and IL-13. ...It is evident that Th2 cells that enter tissues undergo considerable changes i …
The differentiation of Th2 cells is dependent on transcription factors such as GATA3 and STAT6, which prime Th2 cells for the …
T-cell subsets (Th1 versus Th2).
Romagnani S. Romagnani S. Ann Allergy Asthma Immunol. 2000 Jul;85(1):9-18; quiz 18, 21. doi: 10.1016/S1081-1206(10)62426-X. Ann Allergy Asthma Immunol. 2000. PMID: 10923599 Review.
In contrast, allergen-specific Th2 responses are responsible for atopic disorders in genetically susceptible individuals. ...Finally, the Th1/Th2 paradigm can provide the basis for the development of new types of vaccines against infectious agents and of novel strat …
In contrast, allergen-specific Th2 responses are responsible for atopic disorders in genetically susceptible individuals. ...Finally, …
Dendritic Cell-Mediated Th2 Immunity and Immune Disorders.
Kumar S, Jeong Y, Ashraf MU, Bae YS. Kumar S, et al. Int J Mol Sci. 2019 May 1;20(9):2159. doi: 10.3390/ijms20092159. Int J Mol Sci. 2019. PMID: 31052382 Free PMC article. Review.
DCs induce a Th2 immune response at a certain immune environment. Basophil, eosinophil, mast cells, and type 2 innate lymphoid cells also induce Th2 immunity. ...A recent study has shown that a genetic defect in DCs causes an enhanced Th2 immunity leading to …
DCs induce a Th2 immune response at a certain immune environment. Basophil, eosinophil, mast cells, and type 2 innate lymphoid cells …
TH2 cell development and function.
Walker JA, McKenzie ANJ. Walker JA, et al. Nat Rev Immunol. 2018 Feb;18(2):121-133. doi: 10.1038/nri.2017.118. Epub 2017 Oct 30. Nat Rev Immunol. 2018. PMID: 29082915 Review.
CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm.
Hirahara K, Nakayama T. Hirahara K, et al. Int Immunol. 2016 Apr;28(4):163-71. doi: 10.1093/intimm/dxw006. Epub 2016 Feb 12. Int Immunol. 2016. PMID: 26874355 Free PMC article. Review.
In addition to the classical biphasic model of differentiation of T-helper 1 (Th1) and Th2 cells, unexpected increases in the numbers of CD4(+)T-cell subsets, including Th17, Th9, T follicular-helper (Tfh) and T-regulatory (Treg) cells, have been recognized. ...First, we w …
In addition to the classical biphasic model of differentiation of T-helper 1 (Th1) and Th2 cells, unexpected increases in the numbers …
T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production.
Zhu J. Zhu J. Cytokine. 2015 Sep;75(1):14-24. doi: 10.1016/j.cyto.2015.05.010. Epub 2015 Jun 1. Cytokine. 2015. PMID: 26044597 Free PMC article. Review.
In this review, I will focus on the signaling pathways and key molecules that determine the differentiation of naive CD4 T cells into Th2 cells, and how the expression of Th2 cytokines, especially IL-4 and IL-13, is regulated in Th2 cells. The similarities an …
In this review, I will focus on the signaling pathways and key molecules that determine the differentiation of naive CD4 T cells into Th2
Th1, Th2, and Th17 cytokines in systemic lupus erythematosus.
Muhammad Yusoff F, Wong KK, Mohd Redzwan N. Muhammad Yusoff F, et al. Autoimmunity. 2020 Feb;53(1):8-20. doi: 10.1080/08916934.2019.1693545. Epub 2019 Nov 27. Autoimmunity. 2020. PMID: 31771364
Growing evidence has shown deregulated levels of Th1, Th2, and Th17 cytokines in SLE patients compared to healthy controls associated with disease activity and severity. In this review, we describe and discuss the levels of Th1, Th2, and Th17 cytokines in SLE patien …
Growing evidence has shown deregulated levels of Th1, Th2, and Th17 cytokines in SLE patients compared to healthy controls associated …
Orchestration between ILC2s and Th2 cells in shaping type 2 immune responses.
Gurram RK, Zhu J. Gurram RK, et al. Cell Mol Immunol. 2019 Mar;16(3):225-235. doi: 10.1038/s41423-019-0210-8. Epub 2019 Feb 21. Cell Mol Immunol. 2019. PMID: 30792500 Free PMC article. Review.
The classical model of type 2 immunity mainly involves the differentiation of type 2 T helper (Th2) cells and the production of distinct type 2 cytokines, including interleukin-4 (IL-4), IL-5, and IL-13. ...In this review, we discuss recent advances in our understanding of …
The classical model of type 2 immunity mainly involves the differentiation of type 2 T helper (Th2) cells and the production of disti …
Helminth-induced Th2 cell dysfunction is distinct from exhaustion and is maintained in the absence of antigen.
Knipper JA, Ivens A, Taylor MD. Knipper JA, et al. PLoS Negl Trop Dis. 2019 Dec 9;13(12):e0007908. doi: 10.1371/journal.pntd.0007908. eCollection 2019 Dec. PLoS Negl Trop Dis. 2019. PMID: 31815932 Free PMC article.
This study aimed to elucidate the transcriptional changes underlying Th2 cell-intrinsic hypo-responsiveness, and whether it represents a unique and stable state of Th2 cell differentiation. ...Contrasting with their lost ability to produce Th2 cytokines, hypo …
This study aimed to elucidate the transcriptional changes underlying Th2 cell-intrinsic hypo-responsiveness, and whether it represent …
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