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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1972 3
1973 6
1974 15
1975 16
1976 31
1977 35
1978 46
1979 200
1980 484
1981 730
1982 864
1983 976
1984 976
1985 972
1986 855
1987 835
1988 793
1989 748
1990 791
1991 651
1992 501
1993 534
1994 451
1995 358
1996 349
1997 345
1998 354
1999 363
2000 407
2001 514
2002 588
2003 723
2004 919
2005 1166
2006 1533
2007 1895
2008 2347
2009 2572
2010 2799
2011 3029
2012 3065
2013 3244
2014 3245
2015 3395
2016 3212
2017 3258
2018 3300
2019 3296
2020 1917
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54,884 results
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Next-generation regulatory T cell therapy.
Ferreira LMR, Muller YD, Bluestone JA, Tang Q. Ferreira LMR, et al. Nat Rev Drug Discov. 2019 Oct;18(10):749-769. doi: 10.1038/s41573-019-0041-4. Epub 2019 Sep 20. Nat Rev Drug Discov. 2019. PMID: 31541224 Review.
Regulatory T cells (T(reg) cells) are a small subset of immune cells that are dedicated to curbing excessive immune activation and maintaining immune homeostasis. ...Indeed, early-phase clinical trials of T(reg) cell therapy have shown feasibili
Regulatory T cells (T(reg) cells) are a small subset of immune cells that are dedicated to curbing excessive immune act
Taking regulatory T-cell therapy one step further.
Sicard A, Boardman DA, Levings MK. Sicard A, et al. Curr Opin Organ Transplant. 2018 Oct;23(5):509-515. doi: 10.1097/MOT.0000000000000566. Curr Opin Organ Transplant. 2018. PMID: 30063480 Review.
PURPOSE OF REVIEW: Adoptive cell therapy using CD4FOXP3 regulatory T cells (Treg) has emerged as a promising therapeutic strategy to treat autoimmunity and alloimmunity. ...RECENT FINDINGS: Antigen-specific Tregs can be generated by genetically modifyi …
PURPOSE OF REVIEW: Adoptive cell therapy using CD4FOXP3 regulatory T cells (Treg) has emerged as a promising the …
Cell Therapy in Kidney Transplantation: Focus on Regulatory T Cells.
Zwang NA, Leventhal JR. Zwang NA, et al. J Am Soc Nephrol. 2017 Jul;28(7):1960-1972. doi: 10.1681/ASN.2016111206. Epub 2017 May 2. J Am Soc Nephrol. 2017. PMID: 28465379 Free PMC article. Review.
Use of a patient's own suppressive regulatory T cells (Tregs) is an attractive biologic approach to reduce this burden. Here, we review the immunologic underpinnings of Treg therapy and technical challenges to developing successful cell therapy. These …
Use of a patient's own suppressive regulatory T cells (Tregs) is an attractive biologic approach to reduce this burden. Here, …
Human FOXP3(+) Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer.
Wing JB, Tanaka A, Sakaguchi S. Wing JB, et al. Immunity. 2019 Feb 19;50(2):302-316. doi: 10.1016/j.immuni.2019.01.020. Immunity. 2019. PMID: 30784578 Free article. Review.
Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a critical role in the maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in single cell analyses have revealed a range of Treg cell a
Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a critical role in the maintenance of immune h
Transcriptional modulation of regulatory T cell development by novel regulators NR4As.
Won HY, Hwang ES. Won HY, et al. Arch Pharm Res. 2016 Nov;39(11):1530-1536. doi: 10.1007/s12272-016-0803-z. Epub 2016 Oct 25. Arch Pharm Res. 2016. PMID: 27778276 Review.
Regulatory T (Treg) cells with high expression of both CD25 and Foxp3 are developed in the thymus and also peripheral tissues. ...Treg cell development is associated with the induction of and epigenetic alterations of forkhead transcription fact
Regulatory T (Treg) cells with high expression of both CD25 and Foxp3 are developed in the thymus and also peripheral t
Foxp3, Regulatory T Cell, and Autoimmune Diseases.
Tao JH, Cheng M, Tang JP, Liu Q, Pan F, Li XP. Tao JH, et al. Inflammation. 2017 Feb;40(1):328-339. doi: 10.1007/s10753-016-0470-8. Inflammation. 2017. PMID: 27882473 Review.
Regulatory T cells (Tregs) represent a cell type that promotes immune tolerance to autologous components and maintains immune system homeostasis. ...Insights into modulating Treg differentiation on the level of DNA transcription or protein modification
Regulatory T cells (Tregs) represent a cell type that promotes immune tolerance to autologous components and maintains
Regulatory T Cell Development in the Thymus.
Owen DL, Sjaastad LE, Farrar MA. Owen DL, et al. J Immunol. 2019 Oct 15;203(8):2031-2041. doi: 10.4049/jimmunol.1900662. J Immunol. 2019. PMID: 31591259 Review.
Development of a comprehensive regulatory T (T(reg)) cell compartment in the thymus is required to maintain immune homeostasis and prevent autoimmunity. In this study, we review cellular and molecular determinants of T(reg) cell developme …
Development of a comprehensive regulatory T (T(reg)) cell compartment in the thymus is required to maintain immu …
Role of regulatory T cell in the pathogenesis of inflammatory bowel disease.
Yamada A, Arakaki R, Saito M, Tsunematsu T, Kudo Y, Ishimaru N. Yamada A, et al. World J Gastroenterol. 2016 Feb 21;22(7):2195-205. doi: 10.3748/wjg.v22.i7.2195. World J Gastroenterol. 2016. PMID: 26900284 Free PMC article. Review.
Regulatory T (Treg) cells play key roles in various immune responses. For example, Treg cells contribute to the complex pathogenesis of inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis during onset or development
Regulatory T (Treg) cells play key roles in various immune responses. For example, Treg cells contribute to the
The Effect of TNF-α on Regulatory T Cell Function in Graft-versus-Host Disease.
Mancusi A, Piccinelli S, Velardi A, Pierini A. Mancusi A, et al. Front Immunol. 2018 Feb 28;9:356. doi: 10.3389/fimmu.2018.00356. eCollection 2018. Front Immunol. 2018. PMID: 29541073 Free PMC article. Review.
FoxP3(+) regulatory T cells (Tregs) are a subset of CD4(+) T cells that can suppress proliferation and effector functions of T cells, B cells, NK cells, and antigen-presenting cells. Treg deficiency causes dramatic immunologic disease in both an …
FoxP3(+) regulatory T cells (Tregs) are a subset of CD4(+) T cells that can suppress proliferation and effector functio …
Regulatory T-cell therapy for autoimmune and autoinflammatory diseases: The next frontier.
Esensten JH, Muller YD, Bluestone JA, Tang Q. Esensten JH, et al. J Allergy Clin Immunol. 2018 Dec;142(6):1710-1718. doi: 10.1016/j.jaci.2018.10.015. Epub 2018 Oct 25. J Allergy Clin Immunol. 2018. PMID: 30367909 Free article. Review.
Forkhead box P3-expressing regulatory T (Treg) cells are essential for self-tolerance, with an emerging role in tissue repair and regeneration. ...We point out challenges in development of Treg cell therapy and speculate how synthetic biology ca …
Forkhead box P3-expressing regulatory T (Treg) cells are essential for self-tolerance, with an emerging role in tissue …
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