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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 2
1995 1
1996 1
1997 1
1998 1
1999 2
2000 5
2001 7
2002 10
2003 27
2004 50
2005 43
2006 75
2007 100
2008 90
2009 134
2010 153
2011 167
2012 178
2013 221
2014 240
2015 258
2016 250
2017 235
2018 265
2019 289
2020 224
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2,659 results
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XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway.
Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y, Mai J, Shen H, Hu DZ, Adoro S, Hu B, Song M, Tan C, Landis MD, Ferrari M, Shin SJ, Brown M, Chang JC, Liu XS, Glimcher LH. Chen X, et al. Nature. 2014 Apr 3;508(7494):103-107. doi: 10.1038/nature13119. Epub 2014 Mar 23. Nature. 2014. PMID: 24670641 Free PMC article.
Here we report that XBP1 is activated in TNBC and has a pivotal role in the tumorigenicity and progression of this human breast cancer subtype. ...Genome-wide mapping of the XBP1 transcriptional regulatory network revealed that XBP1 drives TNBC tumorigenicity …
Here we report that XBP1 is activated in TNBC and has a pivotal role in the tumorigenicity and progression of this human breast cance …
Roles of Endoplasmic Reticulum Stress in Immune Responses.
So JS. So JS. Mol Cells. 2018 Aug 31;41(8):705-716. doi: 10.14348/molcells.2018.0241. Epub 2018 Jul 30. Mol Cells. 2018. PMID: 30078231 Free PMC article. Review.
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis.
Cubillos-Ruiz JR, Silberman PC, Rutkowski MR, Chopra S, Perales-Puchalt A, Song M, Zhang S, Bettigole SE, Gupta D, Holcomb K, Ellenson LH, Caputo T, Lee AH, Conejo-Garcia JR, Glimcher LH. Cubillos-Ruiz JR, et al. Cell. 2015 Jun 18;161(7):1527-38. doi: 10.1016/j.cell.2015.05.025. Epub 2015 Jun 11. Cell. 2015. PMID: 26073941 Free PMC article.
Here we show that constitutive activation of XBP1 in tumor-associated DCs (tDCs) drives ovarian cancer (OvCa) progression by blunting anti-tumor immunity. ...Accordingly, DC-specific XBP1 deletion or selective nanoparticle-mediated XBP1 silencing in tDCs rest …
Here we show that constitutive activation of XBP1 in tumor-associated DCs (tDCs) drives ovarian cancer (OvCa) progression by blunting …
Farnesoid X receptor signaling activates the hepatic X-box binding protein 1 pathway in vitro and in mice.
Liu X, Guo GL, Kong B, Hilburn DB, Hubchak SC, Park S, LeCuyer B, Hsieh A, Wang L, Fang D, Green RM. Liu X, et al. Hepatology. 2018 Jul;68(1):304-316. doi: 10.1002/hep.29815. Epub 2018 May 10. Hepatology. 2018. PMID: 29377207 Free PMC article.
FXR agonists increased XBP1 splicing and phosphorylated IRE1α (p-IRE1α) expression. Overexpression of SHP similarly increased XBP1 splicing, XBP1s, and p-IRE1α protein expression. ...CONCLUSION: FXR signaling activates the IRE1α/XBP1 pathway in vivo and in vi …
FXR agonists increased XBP1 splicing and phosphorylated IRE1α (p-IRE1α) expression. Overexpression of SHP similarly increased XBP1
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease.
Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher LH, Blumberg RS. Kaser A, et al. Cell. 2008 Sep 5;134(5):743-56. doi: 10.1016/j.cell.2008.07.021. Cell. 2008. PMID: 18775308 Free PMC article.
The transcription factor XBP1, a key component of the endoplasmic reticulum (ER) stress response, is required for development and maintenance of secretory cells and linked to JNK activation. ...Hence, intestinal inflammation can originate solely from XBP1 abnormalit …
The transcription factor XBP1, a key component of the endoplasmic reticulum (ER) stress response, is required for development and mai …
Loss of X-box binding protein 1 in Müller cells augments retinal inflammation in a mouse model of diabetes.
Yang J, Chen C, McLaughlin T, Wang Y, Le YZ, Wang JJ, Zhang SX. Yang J, et al. Diabetologia. 2019 Mar;62(3):531-543. doi: 10.1007/s00125-018-4776-y. Epub 2019 Jan 6. Diabetologia. 2019. PMID: 30612139 Free PMC article.
METHODS: MG-specific conditional Xbp1 knockout (Xbp1(Müller-/-)) mice were generated by crossing Xbp1 flox/flox mice with Müller-Cre transgenic mice. ...Primary Müller cells were isolated from Xbp1(Müller-/-) and Xbp1(Müller+/+) mice and exposed …
METHODS: MG-specific conditional Xbp1 knockout (Xbp1(Müller-/-)) mice were generated by crossing Xbp1 flox/flox mice wi …
Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling.
Spaan CN, Smit WL, van Lidth de Jeude JF, Meijer BJ, Muncan V, van den Brink GR, Heijmans J. Spaan CN, et al. Cell Death Dis. 2019 Jun 21;10(7):490. doi: 10.1038/s41419-019-1729-4. Cell Death Dis. 2019. PMID: 31227689 Free PMC article.
How downstream activation of XBP1 and ATF6 influences intestinal stemness and proliferation remains largely unknown. We generated colorectal cancer cells (LS174T) that harbor doxycycline inducible expression of the active forms of either XBP1(s) or ATF6(1-373). ...W …
How downstream activation of XBP1 and ATF6 influences intestinal stemness and proliferation remains largely unknown. We generated col …
The Multiple Roles of XBP1 in Regulation of Glucose and Lipid Metabolism.
Yang J, Wu X, Wu X, Zhou D, Lin T, Ding S, Zhang Y, Xue J, Zhuge Q. Yang J, et al. Curr Protein Pept Sci. 2017;18(6):630-635. doi: 10.2174/1389203717666160627085011. Curr Protein Pept Sci. 2017. PMID: 27356931 Review.
At the center of XBP1's broad effects is its remarkable metabolic housekeeper function. XBP1 decreased glucose dysfunction via funneling its effects on improving insulin sensitivity and stimulating insulin secretion. ...In this review, we highlight the vital mechani …
At the center of XBP1's broad effects is its remarkable metabolic housekeeper function. XBP1 decreased glucose dysfunction via …
Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation.
Pramanik J, Chen X, Kar G, Henriksson J, Gomes T, Park JE, Natarajan K, Meyer KB, Miao Z, McKenzie ANJ, Mahata B, Teichmann SA. Pramanik J, et al. Genome Med. 2018 Oct 24;10(1):76. doi: 10.1186/s13073-018-0589-3. Genome Med. 2018. PMID: 30355343 Free PMC article.
To identify direct target genes of XBP1 and define XBP1's regulatory network, we performed XBP1 ChIPmentation (ChIP-seq). We validated our predictions by flow cytometry, ELISA, and qPCR. ...Our high-quality genome-wide XBP1 ChIP and gene expression dat …
To identify direct target genes of XBP1 and define XBP1's regulatory network, we performed XBP1 ChIPmentation (ChIP-seq …
The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development.
Huang HW, Zeng X, Rhim T, Ron D, Ryoo HD. Huang HW, et al. J Cell Sci. 2017 Sep 15;130(18):3040-3049. doi: 10.1242/jcs.203612. Epub 2017 Aug 3. J Cell Sci. 2017. PMID: 28775151 Free PMC article.
In cultured metazoan cells, IRE1 also exhibits XBP1-independent biochemical activities. IRE1 and XBP1 are developmentally essential genes in Drosophila and mammals, but the source of the physiological ER stress and the relative contributions of XBP1 activatio …
In cultured metazoan cells, IRE1 also exhibits XBP1-independent biochemical activities. IRE1 and XBP1 are developmentally esse …
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