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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1954 1
1957 2
1959 1
1960 3
1961 2
1965 8
1966 27
1967 32
1968 50
1969 90
1970 111
1971 114
1972 119
1973 134
1974 108
1975 95
1976 80
1977 79
1978 65
1979 70
1980 64
1981 56
1982 59
1983 69
1984 85
1985 106
1986 110
1987 134
1988 116
1989 127
1990 121
1991 104
1992 120
1993 123
1994 98
1995 127
1996 121
1997 107
1998 131
1999 119
2000 134
2001 144
2002 134
2003 142
2004 147
2005 150
2006 152
2007 164
2008 174
2009 183
2010 194
2011 188
2012 168
2013 179
2014 166
2015 164
2016 150
2017 157
2018 135
2019 114
2020 51
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6,182 results
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Page 1
Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis.
Timmer A, Patton PH, Chande N, McDonald JW, MacDonald JK. Timmer A, et al. Cochrane Database Syst Rev. 2016 May 18;2016(5):CD000478. doi: 10.1002/14651858.CD000478.pub4. Cochrane Database Syst Rev. 2016. PMID: 27192092 Free PMC article. Review.
In ulcerative colitis, the evidence for the effectiveness of azathioprine and 6-mercaptopurine for the maintenance of remission is still controversial. OBJECTIVES: To assess the effectiveness and safety of azathioprine and 6-mercaptopurine for maintain …
In ulcerative colitis, the evidence for the effectiveness of azathioprine and 6-mercaptopurine for the maintenance of remissio …
Reducing risk in thiopurine therapy.
Marinaki AM, Arenas-Hernandez M. Marinaki AM, et al. Xenobiotica. 2020 Jan;50(1):101-109. doi: 10.1080/00498254.2019.1688424. Epub 2019 Nov 12. Xenobiotica. 2020. PMID: 31682552 Review.
The thiopurine drugs azathioprine and mercaptopurine are effective in the treatment of disorders of immune regulation and acute lymphoblastic leukaemia. ...
The thiopurine drugs azathioprine and mercaptopurine are effective in the treatment of disorders of immune regulation and acute lymph …
Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes.
Petit E, Langouet S, Akhdar H, Nicolas-Nicolaz C, Guillouzo A, Morel F. Petit E, et al. Toxicol In Vitro. 2008 Apr;22(3):632-42. doi: 10.1016/j.tiv.2007.12.004. Epub 2008 Jan 25. Toxicol In Vitro. 2008. PMID: 18222062
Previous studies have demonstrated that azathioprine decreased the viability of rat hepatocytes. In order to investigate cytotoxic effects of thiopurines in human liver, we used primary human hepatocytes and a highly differentiated human hepatoma cell line, HepaRG, treated …
Previous studies have demonstrated that azathioprine decreased the viability of rat hepatocytes. In order to investigate cytotoxic effect
Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease.
Chande N, Townsend CM, Parker CE, MacDonald JK. Chande N, et al. Cochrane Database Syst Rev. 2016 Oct 26;10(10):CD000545. doi: 10.1002/14651858.CD000545.pub5. Cochrane Database Syst Rev. 2016. PMID: 27783843 Free PMC article. Review.
OBJECTIVES: The primary objective was to determine the efficacy and safety of azathioprine and 6-mercaptopurine for induction of remission in active Crohn's disease. ...There were no statistically significant differences in withdrawals due to adverse events b …
OBJECTIVES: The primary objective was to determine the efficacy and safety of azathioprine and 6-mercaptopurine for induction …
Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease.
Dubinsky MC, Lamothe S, Yang HY, Targan SR, Sinnett D, Théorêt Y, Seidman EG. Dubinsky MC, et al. Gastroenterology. 2000 Apr;118(4):705-13. doi: 10.1016/s0016-5085(00)70140-5. Gastroenterology. 2000. PMID: 10734022 Clinical Trial.
BACKGROUND & AIMS: The effects of 6-mercaptopurine (6-MP) are mediated via its intracellular conversion to 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP) nucleotide metabolites, the latter genetically controlled …
BACKGROUND & AIMS: The effects of 6-mercaptopurine (6-MP) are mediated via its intracellular conversion to …
[The frequency and the course of the adverse effects of azathioprine/6-mercaptopurine treatment in patients with inflammatory bowel disease].
Kim JH, Cheon JH, Kim WH. Kim JH, et al. Korean J Gastroenterol. 2008 May;51(5):291-7. Korean J Gastroenterol. 2008. PMID: 18516013 Korean.
BACKGROUND/AIMS: This study was to evaluate the frequency and the course of the adverse effects of AZA/6-MP in Korean patients with inflammatory bowel disease (IBD). ...Thirty-eight patients (28.6%) required the discontinuation of medication due to …
BACKGROUND/AIMS: This study was to evaluate the frequency and the course of the adverse effects of AZA/6-MP in Korean p …
Polymorphism of ITPA 94C>A and risk of adverse effects among patients with acute lymphoblastic leukaemia treated with 6-mercaptopurine.
Wan Rosalina WR, Teh LK, Mohamad N, Nasir A, Yusoff R, Baba AA, Salleh MZ. Wan Rosalina WR, et al. J Clin Pharm Ther. 2012 Apr;37(2):237-41. doi: 10.1111/j.1365-2710.2011.01272.x. Epub 2011 May 5. J Clin Pharm Ther. 2012. PMID: 21545474
WHAT IS KNOWN AND OBJECTIVE: Genetic polymorphisms of thiopurine S-methyltransferase (TPMT) and inosine triphosphate pyrophosphohydrolase (ITPA 94C>A) contribute to variable responses, including fatal adverse effects, among subjects treated with 6-merca
WHAT IS KNOWN AND OBJECTIVE: Genetic polymorphisms of thiopurine S-methyltransferase (TPMT) and inosine triphosphate pyrophosphohydrolase (I …
[Susceptibility to 6-mercaptopurine toxicity related with NUDT15 and ABCC4 variants in Japanese childhood acute lymphoblastic leukemia].
Tanaka Y. Tanaka Y. Rinsho Ketsueki. 2017;58(8):950-956. doi: 10.11406/rinketsu.58.950. Rinsho Ketsueki. 2017. PMID: 28883280 Japanese.
6-Mercaptopurine (6-MP) is one of the main components for the treatment of childhood acute lymphoblastic leukemia (ALL). However, many patients require a dose reduction of 6-MP due to its severe toxicities. NUDT15 variants are one of the factors that c
6-Mercaptopurine (6-MP) is one of the main components for the treatment of childhood acute lymphoblastic leukemia (ALL)
Update 2014: advances to optimize 6-mercaptopurine and azathioprine to reduce toxicity and improve efficacy in the management of IBD.
Amin J, Huang B, Yoon J, Shih DQ. Amin J, et al. Inflamm Bowel Dis. 2015 Feb;21(2):445-52. doi: 10.1097/MIB.0000000000000197. Inflamm Bowel Dis. 2015. PMID: 25248004 Review.
BACKGROUND: The thiopurine drugs, 6-mercaptopurine (6-MP) and azathioprine (AZA), remain as a mainstay therapy in inflammatory bowel disease (IBD). ...RESULTS: Monitoring thiopurine metabolites can assist physicians in optimizing 6-MP and AZA therapy i …
BACKGROUND: The thiopurine drugs, 6-mercaptopurine (6-MP) and azathioprine (AZA), remain as a mainstay therapy in infla …
Oral administration of non-absorbable delayed release 6-mercaptopurine is locally active in the gut, exerts a systemic immune effect and alleviates Crohn's disease with low rate of side effects: results of double blind Phase II clinical trial.
Israeli E, Goldin E, Fishman S, Konikoff F, Lavy A, Chowers Y, Melzer E, Lahat A, Mahamid M, Shirin H, Nussinson E, Segol O, Ya'acov AB, Shabbat Y, Ilan Y. Israeli E, et al. Clin Exp Immunol. 2015 Aug;181(2):362-72. doi: 10.1111/cei.12640. Clin Exp Immunol. 2015. PMID: 25846055 Free PMC article. Clinical Trial.
Therapy for Crohn's disease (CD) with thiopurines is limited by systemic side effects. A novel formulation of fixed-dose, delayed-release 6-mercaptopurine (DR-6MP) was developed, with local effect on the gut immune system and minimal absorption. The aim of th …
Therapy for Crohn's disease (CD) with thiopurines is limited by systemic side effects. A novel formulation of fixed-dose, delayed-rel …
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