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2011 5
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2018 6
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Page 1
A Mouse Model of Autoimmune Cholangitis via Syngeneic Bile Duct Protein Immunization.
Ma WT, Liu QZ, Yang JB, Yang YQ, Zhao ZB, Ma HD, Gershwin ME, Lian ZX. Ma WT, et al. Sci Rep. 2017 Nov 10;7(1):15246. doi: 10.1038/s41598-017-15661-6. Sci Rep. 2017. PMID: 29127360 Free PMC article.
Several mouse models have been used to clarify the pathogenesis of PBC and are generally considered reflective of an autoimmune cholangitis. ...None have focused on the classic models of breaking tolerance, namely immunization with self-tissue. Here, w …
Several mouse models have been used to clarify the pathogenesis of PBC and are generally considered reflective of an autoimmune
New insights into autoimmune cholangitis through animal models.
Trauner M, Fickert P, Baghdasaryan A, Claudel T, Halilbasic E, Moustafa T, Wagner M, Zollner G. Trauner M, et al. Dig Dis. 2010;28(1):99-104. doi: 10.1159/000282072. Epub 2010 May 7. Dig Dis. 2010. PMID: 20460897 Review.
Improving our understanding of the pathogenesis of chronic immune-mediated cholangiopathies such as primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), as well as the development of novel diagnostic, prognostic and therapeutic tools for these disorder …
Improving our understanding of the pathogenesis of chronic immune-mediated cholangiopathies such as primary biliary cirrhosis (PBC) and prim …
Experimental autoimmune cholangitis: a mouse model of immune-mediated cholangiopathy.
Jones DE, Palmer JM, Kirby JA, De Cruz DJ, McCaughan GW, Sedgwick JD, Yeaman SJ, Burt AD, Bassendine MF. Jones DE, et al. Liver. 2000 Oct;20(5):351-6. doi: 10.1034/j.1600-0676.2000.020005351.x. Liver. 2000. PMID: 11092252
Although auto-reactive immune responses against pyruvate dehydrogenase complex (PDC) have been characterised in PBC, the lack of an animal model of the disease has limited study of the mechanisms of disease induction and the development of novel approaches to therap …
Although auto-reactive immune responses against pyruvate dehydrogenase complex (PDC) have been characterised in PBC, the lack of an anima
Endogenous IL-10 maintains immune tolerance but IL-10 gene transfer exacerbates autoimmune cholangitis.
Hsueh YH, Chen HW, Syu BJ, Lin CI, Leung PSC, Gershwin ME, Chuang YH. Hsueh YH, et al. J Autoimmun. 2018 Dec;95:159-170. doi: 10.1016/j.jaut.2018.09.009. Epub 2018 Sep 28. J Autoimmun. 2018. PMID: 30274824 Free PMC article.
Taking advantage of our established mouse model of autoimmune cholangitis using 2-octynoic acid conjugated ovalbumin (2-OA-OVA) induction, we compared liver pathology, immune cell populations and antimitochondrial antibodies between IL-10 knockout and wild ty …
Taking advantage of our established mouse model of autoimmune cholangitis using 2-octynoic acid conjugated ovalbumin (2 …
Dual Roles of IFN-γ and IL-4 in the Natural History of Murine Autoimmune Cholangitis: IL-30 and Implications for Precision Medicine.
Syu BJ, Loh CE, Hsueh YH, Gershwin ME, Chuang YH. Syu BJ, et al. Sci Rep. 2016 Oct 10;6:34884. doi: 10.1038/srep34884. Sci Rep. 2016. PMID: 27721424 Free PMC article.
We prepared adeno-associated virus (AAV)-IFN-γ and AAV-IL-4 and studied their individual influences on the natural history of autoimmune cholangitis in this model. ...In contrast, the administration of IL-4 does not alter the initiation of autoimmune
We prepared adeno-associated virus (AAV)-IFN-γ and AAV-IL-4 and studied their individual influences on the natural history of autoimmune
Murine autoimmune cholangitis requires two hits: cytotoxic KLRG1(+) CD8 effector cells and defective T regulatory cells.
Huang W, Kachapati K, Adams D, Wu Y, Leung PS, Yang GX, Zhang W, Ansari AA, Flavell RA, Gershwin ME, Ridgway WM. Huang W, et al. J Autoimmun. 2014 May;50:123-34. doi: 10.1016/j.jaut.2014.01.034. Epub 2014 Feb 18. J Autoimmun. 2014. PMID: 24556277 Free PMC article.
Primary biliary cirrhosis (PBC) is an enigmatic disease mediated by autoimmune destruction of cholangiocytes in hepatic bile ducts. ...These results emphasize that autoimmune cholangitis requires defects in both the T effector and regulatory compartments, and …
Primary biliary cirrhosis (PBC) is an enigmatic disease mediated by autoimmune destruction of cholangiocytes in hepatic bile ducts. . …
The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity.
Bae HR, Hodge DL, Yang GX, Leung PSC, Chodisetti SB, Valencia JC, Sanford M, Fenimore JM, Rahman ZSM, Tsuneyama K, Norman GL, Gershwin ME, Young HA. Bae HR, et al. Hepatology. 2018 Apr;67(4):1408-1419. doi: 10.1002/hep.29524. Epub 2018 Feb 18. Hepatology. 2018. PMID: 28921595 Free PMC article.
We have reported on a murine model of autoimmune cholangitis, generated by altering the AU-rich element (ARE) by deletion of the interferon gamma (IFN-γ) 3' untranslated region (coined ARE-Del(-/-) ), that has striking similarities to human primary biliary …
We have reported on a murine model of autoimmune cholangitis, generated by altering the AU-rich element (ARE) by deleti …
The multi-hit hypothesis of primary biliary cirrhosis: polyinosinic-polycytidylic acid (poly I:C) and murine autoimmune cholangitis.
Ambrosini YM, Yang GX, Zhang W, Tsuda M, Shu S, Tsuneyama K, Leung PS, Ansari AA, Coppel RL, Gershwin ME. Ambrosini YM, et al. Clin Exp Immunol. 2011 Oct;166(1):110-20. doi: 10.1111/j.1365-2249.2011.04453.x. Clin Exp Immunol. 2011. PMID: 21910728 Free PMC article.
A void in understanding primary biliary cirrhosis (PBC) is the absence of appropriate animal models. Our laboratory has studied a murine model of autoimmune cholangitis induced following immunization with 2-octynoic acid (2OA), an antigen identi …
A void in understanding primary biliary cirrhosis (PBC) is the absence of appropriate animal models. Our laboratory has studie …
B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis.
Moritoki Y, Tsuda M, Tsuneyama K, Zhang W, Yoshida K, Lian ZX, Yang GX, Ridgway WM, Wicker LS, Ansari AA, Gershwin ME. Moritoki Y, et al. Cell Immunol. 2011;268(1):16-23. doi: 10.1016/j.cellimm.2011.01.005. Epub 2011 Jan 28. Cell Immunol. 2011. PMID: 21349500 Free PMC article.
There are now several murine models of autoimmune cholangitis that have features both similar and distinct from human PBC. One such model, the NOD.c3c4 mouse, manifests portal cell infiltrates, anti-mitochondrial antibodies but also biliary cysts. The …
There are now several murine models of autoimmune cholangitis that have features both similar and distinct from human P …
The Critical Role of Chemokine (C-C Motif) Receptor 2-Positive Monocytes in Autoimmune Cholangitis.
Reuveni D, Gore Y, Leung PSC, Lichter Y, Moshkovits I, Kaminitz A, Brazowski E, Lefebvre E, Vig P, Varol C, Halpern Z, Shibolet O, Gershwin ME, Zigmond E. Reuveni D, et al. Front Immunol. 2018 Aug 15;9:1852. doi: 10.3389/fimmu.2018.01852. eCollection 2018. Front Immunol. 2018. PMID: 30158929 Free PMC article.
The therapy of primary biliary cholangitis (PBC) has lagged behind other autoimmune diseases despite significant improvements in our understanding of both immunological and molecular events that lead to loss of tolerance to the E2 component of pyruvate dehydrogenase …
The therapy of primary biliary cholangitis (PBC) has lagged behind other autoimmune diseases despite significant improvements …
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