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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1987 1
1989 2
1990 2
1991 4
1992 3
1994 2
1995 1
1996 3
1997 1
1998 1
1999 2
2001 2
2002 6
2003 4
2004 3
2005 3
2006 6
2007 4
2008 4
2009 3
2010 12
2011 11
2012 14
2013 13
2014 10
2015 9
2016 8
2017 23
2018 25
2019 17
2020 8
2021 1
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184 results
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Page 1
Pathogenesis, diagnosis, and management of cholangiocarcinoma.
Rizvi S, Gores GJ. Rizvi S, et al. Gastroenterology. 2013 Dec;145(6):1215-29. doi: 10.1053/j.gastro.2013.10.013. Epub 2013 Oct 15. Gastroenterology. 2013. PMID: 24140396 Free PMC article. Review.
Targeting FXR in Cholestasis.
Keitel V, Dröge C, Häussinger D. Keitel V, et al. Handb Exp Pharmacol. 2019;256:299-324. doi: 10.1007/164_2019_231. Handb Exp Pharmacol. 2019. PMID: 31201556 Review.
These findings underscore the central role of FXR as regulator of systemic and hepatic BA levels. Therefore, targeting FXR has been exploited in different animal models of both intrahepatic and obstructive cholestasis, and the first FXR agonist obeticholic acid (OCA …
These findings underscore the central role of FXR as regulator of systemic and hepatic BA levels. Therefore, targeting FXR has been exploite …
Innate Lymphoid Cells in Intestinal Inflammation.
Geremia A, Arancibia-Cárcamo CV. Geremia A, et al. Front Immunol. 2017 Oct 13;8:1296. doi: 10.3389/fimmu.2017.01296. eCollection 2017. Front Immunol. 2017. PMID: 29081776 Free PMC article. Review.
The cause of IBD is unknown, but the evidence suggests that an aberrant immune response toward the commensal bacterial flora is responsible for disease in genetically susceptible individuals. Results from animal models of colitis and human studies indicate a role fo …
The cause of IBD is unknown, but the evidence suggests that an aberrant immune response toward the commensal bacterial flora is responsible …
Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice.
Guicciardi ME, Trussoni CE, Krishnan A, Bronk SF, Lorenzo Pisarello MJ, O'Hara SP, Splinter PL, Gao Y, Vig P, Revzin A, LaRusso NF, Gores GJ. Guicciardi ME, et al. J Hepatol. 2018 Sep;69(3):676-686. doi: 10.1016/j.jhep.2018.05.018. Epub 2018 May 24. J Hepatol. 2018. PMID: 29802947 Free PMC article.
BACKGROUND & AIMS: Macrophages contribute to liver disease, but their role in cholestatic liver injury, including primary sclerosing cholangitis (PSC), is unclear. We tested the hypothesis that macrophages contribute to the pathogenesis of, and are therapeutic t …
BACKGROUND & AIMS: Macrophages contribute to liver disease, but their role in cholestatic liver injury, including primary sclerosing …
Etiopathogenesis of autoimmune hepatitis.
Floreani A, Restrepo-Jiménez P, Secchi MF, De Martin S, Leung PSC, Krawitt E, Bowlus CL, Gershwin ME, Anaya JM. Floreani A, et al. J Autoimmun. 2018 Dec;95:133-143. doi: 10.1016/j.jaut.2018.10.020. Epub 2018 Oct 29. J Autoimmun. 2018. PMID: 30385083 Review.
Herein we present a review of the etiology of autoimmune hepatitis including de novo autoimmune hepatitis post-liver transplantation as well as animal models for its study....
Herein we present a review of the etiology of autoimmune hepatitis including de novo autoimmune hepatitis post-liver transplantation as well …
Animal models in primary biliary cirrhosis and primary sclerosing cholangitis.
Pollheimer MJ, Fickert P. Pollheimer MJ, et al. Clin Rev Allergy Immunol. 2015 Jun;48(2-3):207-17. doi: 10.1007/s12016-014-8442-y. Clin Rev Allergy Immunol. 2015. PMID: 25172178 Review.
Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are immune-mediated cholangiopathies with enigmatic etiology and pathogenesis. ...The aim of the current paper is to outline the characteristics of ideal PBC and PSC animal models …
Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are immune-mediated cholangiopathies with enigmatic e …
Cholangiocyte-Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis.
Liu R, Li X, Zhu W, Wang Y, Zhao D, Wang X, Gurley EC, Liang G, Chen W, Lai G, Pandak WM, Robert Lippman H, Bajaj JS, Hylemon PB, Zhou H. Liu R, et al. Hepatology. 2019 Oct;70(4):1317-1335. doi: 10.1002/hep.30662. Epub 2019 May 24. Hepatology. 2019. PMID: 30985008 Free PMC article.
Both bile duct ligation (BDL) and Mdr2 knockout (Mdr2(-/-) ) mouse models were used. Wild-type and H19(maternaldeltaExon1/+) (H19KO) mice were subjected to BDL. ...Collagen gel contraction and bromodeoxyuridine assays were used to determine the effect of exosomal-H19 on HS …
Both bile duct ligation (BDL) and Mdr2 knockout (Mdr2(-/-) ) mouse models were used. Wild-type and H19(maternaldeltaExon1/+) (H19KO) …
Bile acid receptors in the biliary tree: TGR5 in physiology and disease.
Deutschmann K, Reich M, Klindt C, Dröge C, Spomer L, Häussinger D, Keitel V. Deutschmann K, et al. Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1319-1325. doi: 10.1016/j.bbadis.2017.08.021. Epub 2017 Aug 25. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 28844960 Free article. Review.
Decreased TGR5 expression may also contribute to the development or progression of cholangiopathies like primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) since reduced TGR5-dependent cell-protective mechanisms such as bicarbonate sec …
Decreased TGR5 expression may also contribute to the development or progression of cholangiopathies like primary biliary cholangitis …
Animal Models of Autoimmune Liver Diseases: a Comprehensive Review.
Liu SP, Bian ZH, Zhao ZB, Wang J, Zhang W, Leung PSC, Li L, Lian ZX. Liu SP, et al. Clin Rev Allergy Immunol. 2020 Apr;58(2):252-271. doi: 10.1007/s12016-020-08778-6. Clin Rev Allergy Immunol. 2020. PMID: 32076943 Review.
Autoimmune liver diseases (AILDs) are potentially life-threatening chronic liver diseases which include autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and recently characterized IgG4-related sclerosing cholangitis …
Autoimmune liver diseases (AILDs) are potentially life-threatening chronic liver diseases which include autoimmune hepatitis, primary biliar …
Interleukin 2 Promotes Hepatic Regulatory T Cell Responses and Protects From Biliary Fibrosis in Murine Sclerosing Cholangitis.
Taylor AE, Carey AN, Kudira R, Lages CS, Shi T, Lam S, Karns R, Simmons J, Shanmukhappa K, Almanan M, Chougnet CA, Miethke AG. Taylor AE, et al. Hepatology. 2018 Nov;68(5):1905-1921. doi: 10.1002/hep.30061. Epub 2018 Sep 30. Hepatology. 2018. PMID: 29698570 Free PMC article.
In the multidrug resistance protein 2 (Mdr2)(-/-) mouse model, low phospholipid bile instigates biliary epithelial injury, sterile inflammation, and fibrosis, thereby recapitulating disease mechanisms implicated in biliary atresia (BA) and primary sclerosing chol …
In the multidrug resistance protein 2 (Mdr2)(-/-) mouse model, low phospholipid bile instigates biliary epithelial injury, sterile in …
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