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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1959 1
1967 1
1970 2
1971 4
1972 3
1973 7
1974 6
1975 14
1976 11
1977 13
1978 18
1979 13
1980 18
1981 25
1982 13
1983 22
1984 14
1985 12
1986 26
1987 34
1988 29
1989 28
1990 31
1991 30
1992 24
1993 36
1994 32
1995 37
1996 29
1997 32
1998 29
1999 34
2000 38
2001 36
2002 40
2003 43
2004 42
2005 41
2006 34
2007 45
2008 51
2009 47
2010 51
2011 45
2012 48
2013 56
2014 71
2015 71
2016 84
2017 100
2018 99
2019 91
2020 66
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1,688 results
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Page 1
The enzymes, regulation, and genetics of bile acid synthesis.
Russell DW. Russell DW. Annu Rev Biochem. 2003;72:137-74. doi: 10.1146/annurev.biochem.72.121801.161712. Epub 2003 Jan 16. Annu Rev Biochem. 2003. PMID: 12543708 Review.
The synthesis and excretion of bile acids comprise the major pathway of cholesterol catabolism in mammals. Synthesis provides a direct means of converting cholesterol, which is both hydrophobic and insoluble, into a water-soluble and readily excreted molecule …
The synthesis and excretion of bile acids comprise the major pathway of cholesterol catabolism in mammals. Synthesis pr …
Glucose-6-Phosphate Regulates Hepatic Bile Acid Synthesis in Mice.
Hoogerland JA, Lei Y, Wolters JC, de Boer JF, Bos T, Bleeker A, Mulder NL, van Dijk TH, Kuivenhoven JA, Rajas F, Mithieux G, Haeusler RA, Verkade HJ, Bloks VW, Kuipers F, Oosterveer MH. Hoogerland JA, et al. Hepatology. 2019 Dec;70(6):2171-2184. doi: 10.1002/hep.30778. Epub 2019 Jun 24. Hepatology. 2019. PMID: 31102537 Free PMC article.
Bile acid metabolism, in turn, is controlled by several nutrient-sensitive transcription factors. Altered intrahepatic glucose signaling in type 2 diabetes associates with perturbed bile acid synthesis. ...Conclusion: We report that G6P, the pri
Bile acid metabolism, in turn, is controlled by several nutrient-sensitive transcription factors. Altered intrahepatic glucose
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist.
Sayin SI, Wahlström A, Felin J, Jäntti S, Marschall HU, Bamberg K, Angelin B, Hyötyläinen T, Orešič M, Bäckhed F. Sayin SI, et al. Cell Metab. 2013 Feb 5;17(2):225-35. doi: 10.1016/j.cmet.2013.01.003. Cell Metab. 2013. PMID: 23395169 Free article.
Bile acid synthesis is under negative feedback control through activation of the nuclear receptor farnesoid X receptor (FXR) in the ileum and liver. ...These studies suggest that the gut microbiota not only regulates secondary bile acid metaboli
Bile acid synthesis is under negative feedback control through activation of the nuclear receptor farnesoid X receptor
FGF21 acts as a negative regulator of bile acid synthesis.
Chen MM, Hale C, Stanislaus S, Xu J, Véniant MM. Chen MM, et al. J Endocrinol. 2018 May;237(2):139-152. doi: 10.1530/JOE-17-0727. J Endocrinol. 2018. PMID: 29615519
Long-term administration of the long-acting FGF21 analogs in obese cynomolgus monkeys suppressed plasma total bile acid and 7α-hydroxy-4-cholesten-3-one levels, a biomarker for bile acid synthesis. Collectively, these data reveal a previously un …
Long-term administration of the long-acting FGF21 analogs in obese cynomolgus monkeys suppressed plasma total bile acid and 7α …
[An overview of bile acid synthesis and its physiological and pathological functions].
Liu X, Wang Y. Liu X, et al. Yi Chuan. 2019 May 20;41(5):365-374. doi: 10.16288/j.yczz.19-011. Yi Chuan. 2019. PMID: 31106772 Review. Chinese.
After a meal, the stored bile acids are released into small intestines. In the intestine, about 95% of bile acids will be re-absorbed and travel back into the liver through port veins, which is called bile acid enterohepatic circulation. ...In the curr …
After a meal, the stored bile acids are released into small intestines. In the intestine, about 95% of bile acids will be re-a …
Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer.
Li T, Apte U. Li T, et al. Adv Pharmacol. 2015;74:263-302. doi: 10.1016/bs.apha.2015.04.003. Epub 2015 May 27. Adv Pharmacol. 2015. PMID: 26233910 Free PMC article. Review.
Bile acids are synthesized from cholesterol in the liver. Some cytochrome P450 (CYP) enzymes play key roles in bile acid synthesis. ...In cholestasis, these bile acid-activated receptors regulate a network of genes involved in bile
Bile acids are synthesized from cholesterol in the liver. Some cytochrome P450 (CYP) enzymes play key roles in bile acid
MAFG is a transcriptional repressor of bile acid synthesis and metabolism.
de Aguiar Vallim TQ, Tarling EJ, Ahn H, Hagey LR, Romanoski CE, Lee RG, Graham MJ, Motohashi H, Yamamoto M, Edwards PA. de Aguiar Vallim TQ, et al. Cell Metab. 2015 Feb 3;21(2):298-311. doi: 10.1016/j.cmet.2015.01.007. Cell Metab. 2015. PMID: 25651182 Free PMC article.
Bile acids are synthesized from cholesterol in the liver, and the key enzymes involved in bile acid synthesis (Cyp7a1, Cyp8b1) are regulated transcriptionally by the nuclear receptor FXR. ...Finally, we identify functional MafG response elements in
Bile acids are synthesized from cholesterol in the liver, and the key enzymes involved in bile acid synthesis (C
Bile acids: regulation of synthesis.
Chiang JY. Chiang JY. J Lipid Res. 2009 Oct;50(10):1955-66. doi: 10.1194/jlr.R900010-JLR200. Epub 2009 Apr 3. J Lipid Res. 2009. PMID: 19346330 Free PMC article. Review.
The enterohepatic circulation of bile acids exerts important physiological functions not only in feedback inhibition of bile acid synthesis but also in control of whole-body lipid homeostasis. ...In the intestine, FXR induces an intestinal hormone, fib …
The enterohepatic circulation of bile acids exerts important physiological functions not only in feedback inhibition of bile
Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism.
Ding L, Chang M, Guo Y, Zhang L, Xue C, Yanagita T, Zhang T, Wang Y. Ding L, et al. Lipids Health Dis. 2018 Dec 19;17(1):286. doi: 10.1186/s12944-018-0939-6. Lipids Health Dis. 2018. PMID: 30567573 Free PMC article.
Among the targets aimed to ameliorating atherosclerotic lesions, inducing bile acid synthesis to eliminate excess cholesterol in body is an effective way. ...Mechanically, TMAO inhibited hepatic bile acid synthesis by specifically repress …
Among the targets aimed to ameliorating atherosclerotic lesions, inducing bile acid synthesis to eliminate excess chole …
Identification of a novel function of hepatic long-chain acyl-CoA synthetase-1 (ACSL1) in bile acid synthesis and its regulation by bile acid-activated farnesoid X receptor.
Singh AB, Dong B, Xu Y, Zhang Y, Liu J. Singh AB, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar;1864(3):358-371. doi: 10.1016/j.bbalip.2018.12.012. Epub 2018 Dec 20. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 30580099 Free PMC article.
Mechanistic investigations of genome-wide gene expression profiling and pathway analysis revealed that ACSL1 depletion repressed expressions of several key enzymes for bile acid biosynthesis, consequently leading to reduced liver bile acid levels and a …
Mechanistic investigations of genome-wide gene expression profiling and pathway analysis revealed that ACSL1 depletion repressed expressions …
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