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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 2
1961 2
1962 2
1963 1
1989 2
1991 2
1992 5
1993 9
1994 34
1995 73
1996 202
1997 477
1998 954
1999 1533
2000 2179
2001 2700
2002 2972
2003 3738
2004 4072
2005 4359
2006 4846
2007 5268
2008 5352
2009 5561
2010 6010
2011 6432
2012 6943
2013 7480
2014 7703
2015 8124
2016 8150
2017 8405
2018 9052
2019 8844
2020 6812
2021 7
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113,749 results
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Page 1
Inflammatory caspases are innate immune receptors for intracellular LPS.
Shi J, Zhao Y, Wang Y, Gao W, Ding J, Li P, Hu L, Shao F. Shi J, et al. Nature. 2014 Oct 9;514(7521):187-92. doi: 10.1038/nature13683. Epub 2014 Aug 6. Nature. 2014. PMID: 25119034
LPS-induced cytotoxicity was mediated by human caspase-4 that could functionally complement murine caspase-11. Human caspase-4 and the mouse homologue caspase-11 (hereafter referred to as caspase-4/11) and also human caspase-5, directly b …
LPS-induced cytotoxicity was mediated by human caspase-4 that could functionally complement murine caspase-11. Human caspas
Old, new and emerging functions of caspases.
Shalini S, Dorstyn L, Dawar S, Kumar S. Shalini S, et al. Cell Death Differ. 2015 Apr;22(4):526-39. doi: 10.1038/cdd.2014.216. Epub 2014 Dec 19. Cell Death Differ. 2015. PMID: 25526085 Free PMC article. Review.
Caspases are proteases with a well-defined role in apoptosis. However, increasing evidence indicates multiple functions of caspases outside apoptosis. ...Several other caspases have demonstrated anti-tumor roles. Notable among them are caspase-2, -8 an
Caspases are proteases with a well-defined role in apoptosis. However, increasing evidence indicates multiple functions of caspase
Caspases in Cell Death, Inflammation, and Disease.
Van Opdenbosch N, Lamkanfi M. Van Opdenbosch N, et al. Immunity. 2019 Jun 18;50(6):1352-1364. doi: 10.1016/j.immuni.2019.05.020. Immunity. 2019. PMID: 31216460 Free PMC article. Review.
A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in recent years. Important advancements include the identification of additional inflammasome platforms and pathways that regulate activation of inflammatory caspa
A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in recent years. Important …
Caspase family proteases and apoptosis.
Fan TJ, Han LH, Cong RS, Liang J. Fan TJ, et al. Acta Biochim Biophys Sin (Shanghai). 2005 Nov;37(11):719-27. doi: 10.1111/j.1745-7270.2005.00108.x. Acta Biochim Biophys Sin (Shanghai). 2005. PMID: 16270150 Free article. Review.
The activation and function of caspases, involved in the delicate caspase-cascade system, are regulated by various kinds of molecules, such as the inhibitor of apoptosis protein, Bcl-2 family proteins, calpain, and Ca2+. Based on the latest research, the members of …
The activation and function of caspases, involved in the delicate caspase-cascade system, are regulated by various kinds of mo …
Mechanisms of caspase activation and inhibition during apoptosis.
Shi Y. Shi Y. Mol Cell. 2002 Mar;9(3):459-70. doi: 10.1016/s1097-2765(02)00482-3. Mol Cell. 2002. PMID: 11931755 Free article. Review.
Caspases are central components of the machinery responsible for apoptosis. Recent structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome have revealed a conserved mechanism of caspase activation and inhibition. This article reviews the
Caspases are central components of the machinery responsible for apoptosis. Recent structural and biochemical studies on procaspases,
Apoptosis regulation by subcellular relocation of caspases.
Prokhorova EA, Kopeina GS, Lavrik IN, Zhivotovsky B. Prokhorova EA, et al. Sci Rep. 2018 Aug 15;8(1):12199. doi: 10.1038/s41598-018-30652-x. Sci Rep. 2018. PMID: 30111833 Free PMC article.
Importantly, nuclear accumulation of effector caspase-3 as well as initiator caspase-2, -8 and -9 was observed using the developed protocol and immunofluorescence microscopy. ...The entry of initiator caspases to the nucleus was independent of caspase- …
Importantly, nuclear accumulation of effector caspase-3 as well as initiator caspase-2, -8 and -9 was observed using the devel …
Chopping GSDMD: caspase-8 has joined the team of pyroptosis-mediating caspases.
Gram AM, Booty LM, Bryant CE. Gram AM, et al. EMBO J. 2019 May 15;38(10):e102065. doi: 10.15252/embj.2019102065. Epub 2019 Apr 15. EMBO J. 2019. PMID: 30988015 Free PMC article.
nflammatory and apoptotic caspases mediate two distinct forms of cell death: pyroptosis and apoptosis, respectively. Three independent studies have now demonstrated that the “apoptotic” caspase‐8 can cleave gasdermin D (GSDMD) leading to pyroptosis‐like cell death and IL‐1 …
nflammatory and apoptotic caspases mediate two distinct forms of cell death: pyroptosis and apoptosis, respectively. Three independen …
Caspase-9.
Kuida K. Kuida K. Int J Biochem Cell Biol. 2000 Feb;32(2):121-4. doi: 10.1016/s1357-2725(99)00024-2. Int J Biochem Cell Biol. 2000. PMID: 10687948 Review.
Caspase-9 is a member of caspase family of cysteine proteases that have been implicated in apoptosis and cytokine processing. ...The resultant complex recruits Caspase-9 leading to its activation. Activated Caspase-9 cleaves downstream caspases
Caspase-9 is a member of caspase family of cysteine proteases that have been implicated in apoptosis and cytokine processing.
Targeting apoptotic caspases in cancer.
Boice A, Bouchier-Hayes L. Boice A, et al. Biochim Biophys Acta Mol Cell Res. 2020 Jun;1867(6):118688. doi: 10.1016/j.bbamcr.2020.118688. Epub 2020 Feb 19. Biochim Biophys Acta Mol Cell Res. 2020. PMID: 32087180 Review.
Members of the caspase family of proteases play essential roles in the initiation and execution of apoptosis. These caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in respons …
Members of the caspase family of proteases play essential roles in the initiation and execution of apoptosis. These caspases a …
Metacaspase-3 of Plasmodium falciparum: An atypical trypsin-like serine protease.
Kumar B, Verma S, Kashif M, Sharma R, Atul, Dixit R, Singh AP, Pande V, Saxena AK, Abid M, Pandey KC. Kumar B, et al. Int J Biol Macromol. 2019 Oct 1;138:309-320. doi: 10.1016/j.ijbiomac.2019.07.067. Epub 2019 Jul 10. Int J Biol Macromol. 2019. PMID: 31301397
Metacaspases are clan CD cysteine peptidases found in plants, fungi and protozoa that possess a conserved Peptidase_C14 domain, homologous to the human caspases and a catalytic His/Cys dyad. ...Moreover, PfMCA3 was found to be inactive against caspase substrate. Ove …
Metacaspases are clan CD cysteine peptidases found in plants, fungi and protozoa that possess a conserved Peptidase_C14 domain, homologous t …
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