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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1984 2
1985 1
1986 2
1988 1
1990 1
1991 1
1992 1
1993 1
1994 3
1995 4
1996 11
1997 27
1998 20
1999 21
2000 28
2001 39
2002 49
2003 44
2004 56
2005 68
2006 79
2007 80
2008 81
2009 99
2010 104
2011 112
2012 113
2013 108
2014 122
2015 137
2016 131
2017 185
2018 198
2019 176
2020 140
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1,985 results
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Page 1
Cholangiocyte pathobiology.
Banales JM, Huebert RC, Karlsen T, Strazzabosco M, LaRusso NF, Gores GJ. Banales JM, et al. Nat Rev Gastroenterol Hepatol. 2019 May;16(5):269-281. doi: 10.1038/s41575-019-0125-y. Nat Rev Gastroenterol Hepatol. 2019. PMID: 30850822 Free PMC article. Review.
Cholangiocytes are damaged in a variety of human diseases termed cholangiopathies, often causing advanced liver failure. The regulation of cholangiocyte transport properties is increasingly understood, as is their anatomical and functional heterogeneity along the bi
Cholangiocytes are damaged in a variety of human diseases termed cholangiopathies, often causing advanced liver failure. The regulati
A Bile Duct-on-a-Chip With Organ-Level Functions.
Du Y, Khandekar G, Llewellyn J, Polacheck W, Chen CS, Wells RG. Du Y, et al. Hepatology. 2020 Apr;71(4):1350-1363. doi: 10.1002/hep.30918. Epub 2019 Oct 28. Hepatology. 2020. PMID: 31465556 Free PMC article.
APPROACH AND RESULTS: We showed that mouse cholangiocytes in the channel of the device became polarized and formed mature tight junctions, that the permeability of the cholangiocyte monolayer was comparable to ex vivo measurements, and that cholangiocytes in …
APPROACH AND RESULTS: We showed that mouse cholangiocytes in the channel of the device became polarized and formed mature tight junct …
Drug-induced bile duct injury.
Visentin M, Lenggenhager D, Gai Z, Kullak-Ublick GA. Visentin M, et al. Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1498-1506. doi: 10.1016/j.bbadis.2017.08.033. Epub 2017 Sep 4. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 28882625 Free article. Review.
These share common histopathological features with primary biliary cholangitis, such as inflammation and necrosis at the expense of cholangiocytes and, if the insult persists, bile duct loss and biliary cirrhosis. ...This article is part of a Special Issue entitled: Cho
These share common histopathological features with primary biliary cholangitis, such as inflammation and necrosis at the expense of chola
Hepatic senescence, the good and the bad.
Huda N, Liu G, Hong H, Yan S, Khambu B, Yin XM. Huda N, et al. World J Gastroenterol. 2019 Sep 14;25(34):5069-5081. doi: 10.3748/wjg.v25.i34.5069. World J Gastroenterol. 2019. PMID: 31558857 Free PMC article. Review.
The major contributors of senescence properties in the liver are hepatocytes and cholangiocytes. Senescent cells in the liver have been implicated in the etiology of chronic liver diseases including cirrhosis and hepatocellular carcinoma and in the interference of liver re …
The major contributors of senescence properties in the liver are hepatocytes and cholangiocytes. Senescent cells in the liver have be …
Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration.
Raven A, Lu WY, Man TY, Ferreira-Gonzalez S, O'Duibhir E, Dwyer BJ, Thomson JP, Meehan RR, Bogorad R, Koteliansky V, Kotelevtsev Y, Ffrench-Constant C, Boulter L, Forbes SJ. Raven A, et al. Nature. 2017 Jul 20;547(7663):350-354. doi: 10.1038/nature23015. Epub 2017 Jul 12. Nature. 2017. PMID: 28700576 Free PMC article.
First, loss of β1-integrin in hepatocytes with liver injury triggered a ductular reaction of cholangiocyte origin, with approximately 25% of hepatocytes being derived from a non-hepatocyte origin. Second, cholangiocytes were lineage traced with concurrent inhibition …
First, loss of β1-integrin in hepatocytes with liver injury triggered a ductular reaction of cholangiocyte origin, with approximately …
Kras and Tp53 Mutations Cause Cholangiocyte- and Hepatocyte-Derived Cholangiocarcinoma.
Hill MA, Alexander WB, Guo B, Kato Y, Patra K, O'Dell MR, McCall MN, Whitney-Miller CL, Bardeesy N, Hezel AF. Hill MA, et al. Cancer Res. 2018 Aug 15;78(16):4445-4451. doi: 10.1158/0008-5472.CAN-17-1123. Epub 2018 Jun 5. Cancer Res. 2018. PMID: 29871934 Free PMC article.
BilIN precursor lesions were absent in the hepatocyte-derived iCCA models, pointing toward distinct and direct emergence of a malignant cholangiocytic phenotype from injured, oncogenically primed hepatocytes. Tp53 loss enhanced the reprogramming of hepatocytes to cholan
BilIN precursor lesions were absent in the hepatocyte-derived iCCA models, pointing toward distinct and direct emergence of a malignant c
Bile acid receptors in the biliary tree: TGR5 in physiology and disease.
Deutschmann K, Reich M, Klindt C, Dröge C, Spomer L, Häussinger D, Keitel V. Deutschmann K, et al. Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1319-1325. doi: 10.1016/j.bbadis.2017.08.021. Epub 2017 Aug 25. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 28844960 Free article. Review.
Furthermore, in absence of TGR5 cholangiocyte proliferation in response to cholestasis is attenuated and intrahepatic and extrahepatic bile ducts show increased cell damage, underscoring the role of the receptor for biliary physiology. ...Nevertheless, TGR5 overexpression …
Furthermore, in absence of TGR5 cholangiocyte proliferation in response to cholestasis is attenuated and intrahepatic and extrahepati …
Animal models of biliary injury and altered bile acid metabolism.
Mariotti V, Strazzabosco M, Fabris L, Calvisi DF. Mariotti V, et al. Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1254-1261. doi: 10.1016/j.bbadis.2017.06.027. Epub 2017 Jul 11. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 28709963 Free PMC article. Review.
Moreover, recent studies from genetically engineered mice have unveiled 'core' pathways that make the cholangiocyte a pivotal player in liver repair. ...This article is part of a Special Issue entitled: Cholangiocytes in Health and Disease edited by Jesus Banales, M …
Moreover, recent studies from genetically engineered mice have unveiled 'core' pathways that make the cholangiocyte a pivotal player …
Cholangiocyte-Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis.
Liu R, Li X, Zhu W, Wang Y, Zhao D, Wang X, Gurley EC, Liang G, Chen W, Lai G, Pandak WM, Robert Lippman H, Bajaj JS, Hylemon PB, Zhou H. Liu R, et al. Hepatology. 2019 Oct;70(4):1317-1335. doi: 10.1002/hep.30662. Epub 2019 May 24. Hepatology. 2019. PMID: 30985008
However, it remains unclear whether cholangiocyte-derived lncRNA-H19 regulates HSC activation, which is the major focus of this study. ...Exosomes isolated from cultured mouse and human cholangiocytes or mouse serum were used for in vivo transplantation and in vitro …
However, it remains unclear whether cholangiocyte-derived lncRNA-H19 regulates HSC activation, which is the major focus of this study …
Cholangiocyte-derived exosomal long noncoding RNA H19 promotes cholestatic liver injury in mouse and humans.
Li X, Liu R, Huang Z, Gurley EC, Wang X, Wang J, He H, Yang H, Lai G, Zhang L, Bajaj JS, White M, Pandak WM, Hylemon PB, Zhou H. Li X, et al. Hepatology. 2018 Aug;68(2):599-615. doi: 10.1002/hep.29838. Epub 2018 May 2. Hepatology. 2018. PMID: 29425397 Free PMC article.
However, how cholangiocyte-derived H19 suppresses SHP in hepatocytes remains unknown. Here, we report that cholangiocyte-derived exosomes mediate transfer of H19 into hepatocytes and promote cholestatic injury. ...H19-carrying exosomes from the primary cholangioc
However, how cholangiocyte-derived H19 suppresses SHP in hepatocytes remains unknown. Here, we report that cholangiocyte-deriv …
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