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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1909 1
1910 1
1912 3
1913 1
1914 4
1915 3
1916 1
1917 2
1919 1
1921 3
1922 1
1923 1
1924 10
1925 4
1926 3
1927 14
1928 9
1929 6
1930 4
1931 6
1932 10
1933 7
1934 14
1935 8
1936 8
1937 8
1938 7
1939 5
1940 5
1941 3
1942 4
1943 6
1944 6
1945 25
1946 62
1947 69
1948 120
1949 97
1950 149
1951 170
1952 235
1953 285
1954 267
1955 296
1956 296
1957 435
1958 444
1959 509
1960 558
1961 532
1962 686
1963 957
1964 1250
1965 979
1966 1116
1967 1345
1968 1630
1969 1633
1970 1658
1971 1882
1972 2142
1973 2186
1974 2224
1975 2249
1976 2311
1977 2370
1978 2328
1979 2401
1980 2668
1981 2609
1982 2768
1983 2765
1984 2855
1985 3021
1986 3053
1987 3115
1988 3443
1989 3938
1990 4369
1991 4450
1992 4568
1993 4487
1994 4446
1995 4810
1996 4619
1997 4850
1998 4877
1999 5154
2000 5591
2001 6222
2002 6306
2003 6779
2004 7438
2005 8154
2006 8492
2007 9109
2008 9459
2009 9821
2010 10225
2011 10472
2012 10923
2013 11609
2014 12272
2015 12023
2016 11778
2017 11778
2018 11871
2019 11961
2020 12609
2021 960
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Search Results

296,286 results
Results by year
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Page 1
Mechanisms and regulation of cholesterol homeostasis.
Luo J, Yang H, Song BL. Luo J, et al. Nat Rev Mol Cell Biol. 2020 Apr;21(4):225-245. doi: 10.1038/s41580-019-0190-7. Epub 2019 Dec 17. Nat Rev Mol Cell Biol. 2020. PMID: 31848472 Review.
Cholesterol homeostasis is vital for proper cellular and systemic functions. ...Finally, we discuss how these pathways function in a concerted manner to maintain cholesterol homeostasis....
Cholesterol homeostasis is vital for proper cellular and systemic functions. ...Finally, we discuss how these pathways function in a
Physiological and pathological implications of cholesterol.
Cortes VA, Busso D, Maiz A, Arteaga A, Nervi F, Rigotti A. Cortes VA, et al. Front Biosci (Landmark Ed). 2014 Jan 1;19:416-28. doi: 10.2741/4216. Front Biosci (Landmark Ed). 2014. PMID: 24389193 Review.
Cholesterol has evolved to fulfill sophisticated biophysical, cell signaling and endocrine requirements of animal systems. At a cellular level, cholesterol is found in membranes, where it increases both bilayer stiffness and impermeability to water and ions. ...
Cholesterol has evolved to fulfill sophisticated biophysical, cell signaling and endocrine requirements of animal systems. At a cellu
Cholesterol biosensors: A review.
Narwal V, Deswal R, Batra B, Kalra V, Hooda R, Sharma M, Rana JS. Narwal V, et al. Steroids. 2019 Mar;143:6-17. doi: 10.1016/j.steroids.2018.12.003. Epub 2018 Dec 10. Steroids. 2019. PMID: 30543816 Review.
Cholesterol is the most important sterol synthesized by most of the human cells majorly in the liver. ...Biosensing approach overcomes these disadvantages, as these are highly specific, fast, easy, cost-effective, and highly sensitive. The review describes the various c
Cholesterol is the most important sterol synthesized by most of the human cells majorly in the liver. ...Biosensing approach overcome
Cholesterol's location in lipid bilayers.
Marquardt D, Kučerka N, Wassall SR, Harroun TA, Katsaras J. Marquardt D, et al. Chem Phys Lipids. 2016 Sep;199:17-25. doi: 10.1016/j.chemphyslip.2016.04.001. Epub 2016 Apr 4. Chem Phys Lipids. 2016. PMID: 27056099 Review.
Cholesterol's location in lipid bilayers has been studied extensively, and it has been shown - at least in some bilayers - to align differently from its canonical upright orientation, where its hydroxyl group is in the vicinity of the lipid-water interface. In this
Cholesterol's location in lipid bilayers has been studied extensively, and it has been shown - at least in some bilayers - to
How cholesterol stiffens unsaturated lipid membranes.
Chakraborty S, Doktorova M, Molugu TR, Heberle FA, Scott HL, Dzikovski B, Nagao M, Stingaciu LR, Standaert RF, Barrera FN, Katsaras J, Khelashvili G, Brown MF, Ashkar R. Chakraborty S, et al. Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):21896-21905. doi: 10.1073/pnas.2004807117. Epub 2020 Aug 25. Proc Natl Acad Sci U S A. 2020. PMID: 32843347
This observation presents a clear challenge to structure-property relationships and to our understanding of cholesterol-mediated biological functions. Here, using a comprehensive approach-combining neutron spin-echo (NSE) spectroscopy, solid-state deuterium NMR ((2)H NMR) …
This observation presents a clear challenge to structure-property relationships and to our understanding of cholesterol-mediated biol …
Nanoscale dynamics of cholesterol in the cell membrane.
Pinkwart K, Schneider F, Lukoseviciute M, Sauka-Spengler T, Lyman E, Eggeling C, Sezgin E. Pinkwart K, et al. J Biol Chem. 2019 Aug 23;294(34):12599-12609. doi: 10.1074/jbc.RA119.009683. Epub 2019 Jul 3. J Biol Chem. 2019. PMID: 31270209 Free PMC article.
When a cholesterol analogue was localized to the outer leaflet only, the fast diffusion of cholesterol disappeared, and it diffused similarly to phospholipids. Overall, our results suggest that cholesterol diffusion in the cell membrane is heterogeneous and t …
When a cholesterol analogue was localized to the outer leaflet only, the fast diffusion of cholesterol disappeared, and it dif …
Cholesterol reporter molecules.
Gimpl G, Gehrig-Burger K. Gimpl G, et al. Biosci Rep. 2007 Dec;27(6):335-58. doi: 10.1007/s10540-007-9060-1. Biosci Rep. 2007. PMID: 17668316 Review.
In this review, we describe different approaches to detect cholesterol in vitro and in vivo. Cholesterol reporter molecules can be classified in two groups: cholesterol binding molecules and cholesterol analogues. The enzyme cholesterol oxidase …
In this review, we describe different approaches to detect cholesterol in vitro and in vivo. Cholesterol reporter molecules ca …
Interfacial Binding Sites for Cholesterol on TRP Ion Channels.
Lee AG. Lee AG. Biophys J. 2019 Nov 19;117(10):2020-2033. doi: 10.1016/j.bpj.2019.10.011. Epub 2019 Oct 18. Biophys J. 2019. PMID: 31672270 Free PMC article.
Transient receptor potential (TRP) channels are members of a large family of ion channels located in membranes rich in cholesterol, some of whose functions are affected by the cholesterol content of the membrane. ...Cholesterol docking poses determined in thi …
Transient receptor potential (TRP) channels are members of a large family of ion channels located in membranes rich in cholesterol, s …
Chiral Specificity of Cholesterol Orientation Within Cholesterol Binding Sites in Inwardly Rectifying K(+) Channels.
Barbera N, Levitan I. Barbera N, et al. Adv Exp Med Biol. 2019;1115:77-95. doi: 10.1007/978-3-030-04278-3_4. Adv Exp Med Biol. 2019. PMID: 30649756 Review.
Indeed, this strategy was used to demonstrate the direct effect of cholesterol on Kir channel function. However, while this approach can discriminate between direct and indirect effects, it does not account for the promiscuity of cholesterol binding sites, which can …
Indeed, this strategy was used to demonstrate the direct effect of cholesterol on Kir channel function. However, while this approach …
Modes of Cholesterol Binding in Membrane Proteins: A Joint Analysis of 73 Crystal Structures.
Wang C, Ralko A, Ren Z, Rosenhouse-Dantsker A, Yang X. Wang C, et al. Adv Exp Med Biol. 2019;1135:67-86. doi: 10.1007/978-3-030-14265-0_4. Adv Exp Med Biol. 2019. PMID: 31098811 Review.
Cholesterol is a highly asymmetric lipid molecule. As an essential constituent of the cell membrane, cholesterol plays important structural and signaling roles in various biological processes. ...To characterize the cholesterol-protein interactions, we apply
Cholesterol is a highly asymmetric lipid molecule. As an essential constituent of the cell membrane, cholesterol plays importa
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