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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1942 2
1945 1
1952 1
1953 3
1954 1
1955 1
1956 1
1957 1
1958 2
1959 5
1960 3
1961 2
1962 1
1963 2
1964 4
1965 5
1966 8
1967 17
1968 22
1969 32
1970 33
1971 64
1972 75
1973 96
1974 116
1975 466
1976 546
1977 637
1978 562
1979 658
1980 640
1981 602
1982 672
1983 696
1984 682
1985 648
1986 609
1987 605
1988 585
1989 609
1990 579
1991 506
1992 538
1993 506
1994 430
1995 403
1996 436
1997 382
1998 410
1999 402
2000 396
2001 384
2002 340
2003 359
2004 371
2005 423
2006 473
2007 486
2008 477
2009 495
2010 536
2011 571
2012 641
2013 646
2014 624
2015 605
2016 640
2017 640
2018 696
2019 667
2020 560
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24,154 results
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Complement C3 and its polymorphism: biological and clinical consequences.
Delanghe JR, Speeckaert R, Speeckaert MM. Delanghe JR, et al. Pathology. 2014 Jan;46(1):1-10. doi: 10.1097/PAT.0000000000000042. Pathology. 2014. PMID: 24300728 Review.
Complement 3 (C3) is a crucial component of the innate immune system, which in association with other complement proteins, forms a major host mechanism for detection and clearance of potential pathogens. ...In this review the general characteristics and analy
Complement 3 (C3) is a crucial component of the innate immune system, which in association with other complement protei
Molecular characterization of complement component 3 (C3) in Mytilus coruscus improves our understanding of bivalve complement system.
Chen Y, Xu K, Li J, Wang X, Ye Y, Qi P. Chen Y, et al. Fish Shellfish Immunol. 2018 May;76:41-47. doi: 10.1016/j.fsi.2018.02.044. Epub 2018 Feb 24. Fish Shellfish Immunol. 2018. PMID: 29486351
Complement component 3 (C3) plays a central role in the complement system whose activation is essential for all the important functions performed by this system. ...Taken together, these results show that C3 may play an essential role in the immune def
Complement component 3 (C3) plays a central role in the complement system whose activation is essential for all the imp
A novel complement C3 like gene (Lv-C3L) from Litopenaeus vannamei with bacteriolytic and hemolytic activities and its role in antiviral immune response.
Liu Y, Song Q, Li D, Zou R, Zhang Y, Hao S, Geng X, Sun J. Liu Y, et al. Fish Shellfish Immunol. 2019 Aug;91:376-387. doi: 10.1016/j.fsi.2019.05.045. Epub 2019 May 21. Fish Shellfish Immunol. 2019. PMID: 31125666
As a core component of the complement system, complement component 3 (C3) plays a central role in the opsonization of pathogens, immune defense and immune regulation in the mammalian for its activation is required to trigger classical as well as alternative …
As a core component of the complement system, complement component 3 (C3) plays a central role in the opsonization of p …
Complement C3 isoforms in Austrelaps superbus.
Rehana S, Kini RM. Rehana S, et al. Toxicon. 2008 Apr;51(5):864-81. doi: 10.1016/j.toxicon.2007.12.020. Epub 2007 Dec 27. Toxicon. 2008. PMID: 18262580
Complement C3 plays a pivotal role in both classical and alternate pathways. Lower organisms (urochordates and fishes) have multiple isoforms whereas higher organisms have a single C3 gene. ...This is the first report of molecular isoforms of C3 in a r
Complement C3 plays a pivotal role in both classical and alternate pathways. Lower organisms (urochordates and fishes) have mu
Complement C3 and High Risk of Venous Thromboembolism: 80517 Individuals from the Copenhagen General Population Study.
Nørgaard I, Nielsen SF, Nordestgaard BG. Nørgaard I, et al. Clin Chem. 2016 Mar;62(3):525-34. doi: 10.1373/clinchem.2015.251314. Epub 2016 Jan 21. Clin Chem. 2016. PMID: 26797686
The multivariable-adjusted hazard ratio for venous thromboembolism for a 1-g/L increase in complement C3 was 2.43 (1.74-3.40). CONCLUSIONS: High concentrations of complement C3 were associated with high risk of venous thromboembolism in the general pop …
The multivariable-adjusted hazard ratio for venous thromboembolism for a 1-g/L increase in complement C3 was 2.43 (1.74-3.40). …
Complement C3: a molecular mosaic of binding sites.
Fishelson Z. Fishelson Z. Mol Immunol. 1991 Apr-May;28(4-5):545-52. doi: 10.1016/0161-5890(91)90169-k. Mol Immunol. 1991. PMID: 1829504 Review.
Many of the biological activities of the complement system are mediated by C3, the third complement component, and its proteolytic fragments. At the same time, several of the molecules which regulate complement activation target their action at the …
Many of the biological activities of the complement system are mediated by C3, the third complement component, and its …
Complement C3: an emerging risk factor in cardiometabolic disease.
Hertle E, van Greevenbroek MM, Stehouwer CD. Hertle E, et al. Diabetologia. 2012 Apr;55(4):881-4. doi: 10.1007/s00125-012-2462-z. Epub 2012 Jan 27. Diabetologia. 2012. PMID: 22282163 Free PMC article.
C3 is the central component of the complement system and activation of C3 via any of the three major activation pathways-the classical, the lectin and the alternative pathways-results in initiation of the terminal complement pathway and release of the
C3 is the central component of the complement system and activation of C3 via any of the three major activation pathway
Purification and characterization of human and mouse complement C3.
Ruseva MM, Heurich M. Ruseva MM, et al. Methods Mol Biol. 2014;1100:75-91. doi: 10.1007/978-1-62703-724-2_6. Methods Mol Biol. 2014. PMID: 24218251
Complement component C3 is the most abundant complement protein in plasma, central to all three complement activation pathways and essential to complement amplification. Thus, it is one of the most extensively studied complement proteins.
Complement component C3 is the most abundant complement protein in plasma, central to all three complement activ
Efficacy of Targeted Complement Inhibition in Experimental C3 Glomerulopathy.
Ruseva MM, Peng T, Lasaro MA, Bouchard K, Liu-Chen S, Sun F, Yu ZX, Marozsan A, Wang Y, Pickering MC. Ruseva MM, et al. J Am Soc Nephrol. 2016 Feb;27(2):405-16. doi: 10.1681/ASN.2014121195. Epub 2015 Jun 5. J Am Soc Nephrol. 2016. PMID: 26047789 Free PMC article.
C3 glomerulopathy is associated with complement alternative pathway dysregulation, which includes functional defects in complement regulator factor H (FH). ...In a second mouse model with combined deficiency of FH and complement factor I, CR2-FH preven
C3 glomerulopathy is associated with complement alternative pathway dysregulation, which includes functional defects in com
Complement C3 deficiency: human, animal, and experimental models.
Singer L, Colten HR, Wetsel RA. Singer L, et al. Pathobiology. 1994;62(1):14-28. doi: 10.1159/000163873. Pathobiology. 1994. PMID: 8031472 Review.
The third complement component (C3) is a multifunctional glycoprotein that interacts with numerous serum proteins, cell surface receptors, and membrane-associated regulatory proteins. ...Current knowledge of the molecular and cellular basis of complement C
The third complement component (C3) is a multifunctional glycoprotein that interacts with numerous serum proteins, cell surfac …
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