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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1942 2
1953 2
1957 1
1958 1
1959 1
1960 5
1961 4
1962 2
1963 4
1964 4
1965 1
1966 7
1967 12
1968 5
1969 13
1970 17
1971 23
1972 32
1973 31
1974 47
1975 173
1976 179
1977 225
1978 211
1979 246
1980 278
1981 261
1982 256
1983 301
1984 291
1985 292
1986 278
1987 252
1988 280
1989 261
1990 268
1991 236
1992 249
1993 212
1994 185
1995 185
1996 187
1997 158
1998 168
1999 152
2000 148
2001 154
2002 142
2003 172
2004 179
2005 191
2006 200
2007 248
2008 228
2009 218
2010 217
2011 223
2012 246
2013 266
2014 241
2015 243
2016 234
2017 260
2018 256
2019 259
2020 281
2021 24
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10,140 results
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Complement component C4-like protein in Atlantic cod (Gadus morhua L.) - Detection in ontogeny and identification of post-translational deimination in serum and extracellular vesicles.
Lange S, Kraev I, Magnadóttir B, Dodds AW. Lange S, et al. Dev Comp Immunol. 2019 Dec;101:103437. doi: 10.1016/j.dci.2019.103437. Epub 2019 Jul 6. Dev Comp Immunol. 2019. PMID: 31288046
The complement system is a critical part of teleost immune defences, with complement component C4 forming part of the classical and lectin pathways. ...The presence of deiminated C4-like protein in serum and mucosa, as well as in EVs, may suggest C4
The complement system is a critical part of teleost immune defences, with complement component C4 forming part of the c …
The covalent binding story of the complement proteins C3 and C4 (I) 1972-1981.
Law SKA, Levine RP. Law SKA, et al. Immunobiology. 2019 Nov;224(6):827-833. doi: 10.1016/j.imbio.2019.08.003. Epub 2019 Aug 13. Immunobiology. 2019. PMID: 31445811 Review.
With the discovery of an internal thioester by Jim Prahl, Jamila Janatova, Brian Tack and their colleagues, it became clear that the reaction was by an acyl transfer from the thioester of C3 to the target hydroxyl group. Later on they showed that C4 also bound covalently t …
With the discovery of an internal thioester by Jim Prahl, Jamila Janatova, Brian Tack and their colleagues, it became clear that the reactio …
Complement and c4 null alleles in severe chronic adult periodontitis.
Seppänen M, Lokki ML, Notkola IL, Mattila K, Valtonen V, Nieminen A, Vesanen M, Asikainen S, Meri S. Seppänen M, et al. Scand J Immunol. 2007 Feb;65(2):176-81. doi: 10.1111/j.1365-3083.2006.01886.x. Scand J Immunol. 2007. PMID: 17257223 Free article.
We tested whether complement levels are systemically altered and C4 deficiencies associated with severe chronic periodontitis. ...Changes in complement levels may reflect chronic, recurring inflammation. C4 gene deficiencies are associated with predisp …
We tested whether complement levels are systemically altered and C4 deficiencies associated with severe chronic periodontitis. …
Dancing with complement C4 and the RP-C4-CYP21-TNX (RCCX) modules of the major histocompatibility complex.
Yu CY, Chung EK, Yang Y, Blanchong CA, Jacobsen N, Saxena K, Yang Z, Miller W, Varga L, Fust G. Yu CY, et al. Prog Nucleic Acid Res Mol Biol. 2003;75:217-92. doi: 10.1016/s0079-6603(03)75007-7. Prog Nucleic Acid Res Mol Biol. 2003. PMID: 14604014 Review.
The number of the complement component C4 genes varies from 2 to 8 in a diploid genome among different human individuals. ...This review attempts to dissect the sophisticated genetics of complement C4A and C4B. The emphases are on the qualitative and quantita …
The number of the complement component C4 genes varies from 2 to 8 in a diploid genome among different human individuals. ...T …
The intricate role of complement component C4 in human systemic lupus erythematosus.
Yang Y, Chung EK, Zhou B, Lhotta K, Hebert LA, Birmingham DJ, Rovin BH, Yu CY. Yang Y, et al. Curr Dir Autoimmun. 2004;7:98-132. doi: 10.1159/000075689. Curr Dir Autoimmun. 2004. PMID: 14719377 Review.
It was observed about 50 years ago that low serum complement activity or low protein concentrations of complement C4 concurred with disease activities of systemic lupus erythematosus (SLE). ...Likewise, elucidation of epistatic genetic factors interacting wit …
It was observed about 50 years ago that low serum complement activity or low protein concentrations of complement C4 co …
Determination of reference intervals for serum complement C3 and C4 levels in Chinese Han ethnic males.
Qin X, Lu Y, Yang X, Peng Q, Wang J, Mo C, Wu J, Sui J, Liu Y, Huang X, Zhai L, Yang S, Li R, Li S, Yang X, Gao Y, Mo Z. Qin X, et al. Clin Lab. 2014;60(5):775-81. doi: 10.7754/clin.lab.2013.130514. Clin Lab. 2014. PMID: 24839820
BACKGROUND: Clinical laboratory reference intervals (RIs) for serum complement C3 and C4 levels have been established in many countries but there is a lack of published data regarding normal RIs in Chinese population. ...Serum complement C3 and C4 leve …
BACKGROUND: Clinical laboratory reference intervals (RIs) for serum complement C3 and C4 levels have been established in many …
Immunoglobulins and complement factor C4 in adult rhinosinusitis.
Seppänen M, Suvilehto J, Lokki ML, Notkola IL, Järvinen A, Jarva H, Seppälä I, Tahkokallio O, Malmberg H, Meri S, Valtonen V. Seppänen M, et al. Clin Exp Immunol. 2006 Aug;145(2):219-27. doi: 10.1111/j.1365-2249.2006.03134.x. Clin Exp Immunol. 2006. PMID: 16879240 Free PMC article.
We assessed whether complement and its factor C4 or abnormal immunoglobulin levels are associated with chronic or recurrent rhinosinusitis. ...Associated clinical factors were reviewed. Levels of immunoglobulins, plasma C3, C4 and classical pathway haemolytic …
We assessed whether complement and its factor C4 or abnormal immunoglobulin levels are associated with chronic or recurrent rh …
Biosynthesis of complement C4 messenger RNA in normal human kidney.
Feucht HE, Zwirner J, Bevec D, Lang M, Felber E, Riethmüller G, Weiss EH. Feucht HE, et al. Nephron. 1989;53(4):338-42. doi: 10.1159/000185778. Nephron. 1989. PMID: 2601801
The presence of the corresponding messenger RNA (mRNA) was tested by Northern blot analysis. Complement C4 mRNA was found in liver, and with high intensity also in normal kidneys. ...The results, showing that the complement C4 genes are transcribed ver …
The presence of the corresponding messenger RNA (mRNA) was tested by Northern blot analysis. Complement C4 mRNA was found in l …
The complement component C4 of mammals.
Dodds AW, Law SK. Dodds AW, et al. Biochem J. 1990 Jan 15;265(2):495-502. doi: 10.1042/bj2650495. Biochem J. 1990. PMID: 2302180 Free PMC article.
Human complement component C4 is coded by tandem genes located in the HLA class III region. ...In order to gain some insight into the evolutionary history of the duplicated C4 locus, we have purified C4 from a number of other mammalian species, and tes …
Human complement component C4 is coded by tandem genes located in the HLA class III region. ...In order to gain some insight i …
A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4.
Perry AJ, Wijeyewickrema LC, Wilmann PG, Gunzburg MJ, D'Andrea L, Irving JA, Pang SS, Duncan RC, Wilce JA, Whisstock JC, Pike RN. Perry AJ, et al. J Biol Chem. 2013 May 31;288(22):15821-9. doi: 10.1074/jbc.M113.464545. Epub 2013 Apr 16. J Biol Chem. 2013. PMID: 23592783 Free PMC article.
Recognition of foreign targets by antibodies drives sequential activation of two serine proteases, C1r and C1s, which reside within the complement Component 1 (C1) complex. Active C1s propagates the immune response through its ability to bind and cleave the effector molecu …
Recognition of foreign targets by antibodies drives sequential activation of two serine proteases, C1r and C1s, which reside within the c
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