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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 1
1996 1
1997 1
1998 5
1999 3
2000 16
2001 22
2002 47
2003 58
2004 52
2005 77
2006 88
2007 83
2008 93
2009 103
2010 92
2011 109
2012 97
2013 123
2014 94
2015 79
2016 93
2017 83
2018 95
2019 85
2020 58
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1,440 results
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Cytochrome P450 Induction and Xeno-Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator-Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics.
Hakkola J, Bernasconi C, Coecke S, Richert L, Andersson TB, Pelkonen O. Hakkola J, et al. Basic Clin Pharmacol Toxicol. 2018 Sep;123 Suppl 5:42-50. doi: 10.1111/bcpt.13004. Epub 2018 Apr 29. Basic Clin Pharmacol Toxicol. 2018. PMID: 29527807 Free article. Review.
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), aryl hydrocarbon receptor (AHR) and peroxisome proliferator-activated receptor α (PPARα) are ligand-activated transcription factors that regulate expression of many xenobi …
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), aryl hydrocarbon receptor (AHR) and pe …
Constitutive androstane receptor and pregnane X receptor cooperatively ameliorate DSS-induced colitis.
Uehara D, Tojima H, Kakizaki S, Yamazaki Y, Horiguchi N, Takizawa D, Sato K, Yamada M, Uraoka T. Uehara D, et al. Dig Liver Dis. 2019 Feb;51(2):226-235. doi: 10.1016/j.dld.2018.10.008. Epub 2018 Oct 22. Dig Liver Dis. 2019. PMID: 30442521
BACKGROUND: Nuclear receptor pregnane X receptor (PXR) was shown to be protective in case of dextran sulfate sodium (DSS)-induced colitis. Constitutive androstane receptor (CAR) belongs to the same nuclear receptor subfamily with PXR. The …
BACKGROUND: Nuclear receptor pregnane X receptor (PXR) was shown to be protective in case of dextran sulfate sodium (DSS)-indu …
Activation of constitutive androstane receptor inhibits intestinal CFTR-mediated chloride transport.
Kittayaruksakul S, Sawasvirojwong S, Noitem R, Pongkorpsakol P, Muanprasat C, Chatsudthipong V. Kittayaruksakul S, et al. Biomed Pharmacother. 2019 Mar;111:1249-1259. doi: 10.1016/j.biopha.2019.01.015. Epub 2019 Jan 15. Biomed Pharmacother. 2019. PMID: 30841439 Free article.
Constitutive androstane receptor (CAR) belonging to the nuclear receptor superfamily plays an important role in the xenobiotic metabolism and disposition. ...
Constitutive androstane receptor (CAR) belonging to the nuclear receptor superfamily plays an important role in
Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis.
Kettner NM, Voicu H, Finegold MJ, Coarfa C, Sreekumar A, Putluri N, Katchy CA, Lee C, Moore DD, Fu L. Kettner NM, et al. Cancer Cell. 2016 Dec 12;30(6):909-924. doi: 10.1016/j.ccell.2016.10.007. Epub 2016 Nov 23. Cancer Cell. 2016. PMID: 27889186 Free PMC article.
This pathophysiological pathway is driven by jet-lag-induced genome-wide gene deregulation and global liver metabolic dysfunction, with nuclear receptor-controlled cholesterol/bile acid and xenobiotic metabolism among the top deregulated pathways. Ablation of farnesoid X …
This pathophysiological pathway is driven by jet-lag-induced genome-wide gene deregulation and global liver metabolic dysfunction, with nucl …
Regulation of Hepatic Long Noncoding RNAs by Pregnane X Receptor and Constitutive Androstane Receptor Agonists in Mouse Liver.
Dempsey JL, Cui JY. Dempsey JL, et al. Drug Metab Dispos. 2019 Mar;47(3):329-339. doi: 10.1124/dmd.118.085142. Epub 2018 Dec 28. Drug Metab Dispos. 2019. PMID: 30593543 Free PMC article.
The pregnane X receptor (PXR/NR1I2) is a critical xenobiotic-sensing nuclear receptor that regulates the expression of many drug-processing genes, and it has similar target-gene profiles and DNA-binding motifs with another xenobiotic-sensing nuclear receptor, …
The pregnane X receptor (PXR/NR1I2) is a critical xenobiotic-sensing nuclear receptor that regulates the expression of many dr …
Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity.
Chang HY, Chen CJ, Ma WC, Cheng WK, Lin YN, Lee YR, Chen JJ, Lim YP. Chang HY, et al. Phytomedicine. 2017 Dec 1;36:37-49. doi: 10.1016/j.phymed.2017.09.016. Epub 2017 Sep 25. Phytomedicine. 2017. PMID: 29157826
BACKGROUND: Interactions between transcriptional inducers of cytochrome P450 (CYP450) enzymes and therapeutic drugs may be prevented by antagonizing the activation of a nuclear receptor (NR), pregnane X receptor (PXR, NR1I2), thus improving therapeutic efficacy. PUR …
BACKGROUND: Interactions between transcriptional inducers of cytochrome P450 (CYP450) enzymes and therapeutic drugs may be prevented by anta …
Constitutive androstane receptor (CAR) is a xenosensor and target for therapy.
Kachaylo EM, Pustylnyak VO, Lyakhovich VV, Gulyaeva LF. Kachaylo EM, et al. Biochemistry (Mosc). 2011 Oct;76(10):1087-97. doi: 10.1134/S0006297911100026. Biochemistry (Mosc). 2011. PMID: 22098234 Review.
Constitutive androstane receptor (CAR, NR1I3), which is under consideration in this review, is a member of the superfamily of nuclear receptors. ...First, this receptor has structural features that allow it to display constitutive activity in th
Constitutive androstane receptor (CAR, NR1I3), which is under consideration in this review, is a member of the superfam
Constitutive androstane receptor mediates PCB-induced disruption of retinoid homeostasis.
Shmarakov IO, Lee YJ, Jiang H, Blaner WS. Shmarakov IO, et al. Toxicol Appl Pharmacol. 2019 Oct 15;381:114731. doi: 10.1016/j.taap.2019.114731. Epub 2019 Aug 23. Toxicol Appl Pharmacol. 2019. PMID: 31449830 Free PMC article.
Our study provides new insights into molecular interactions between PCBs and retinoids (vitamin A and its metabolites) by defining a role for constitutive androstane receptor (CAR) in the disruption of retinoid homeostasis by non-coplanar 2,2',4,4',5,5'-hexac …
Our study provides new insights into molecular interactions between PCBs and retinoids (vitamin A and its metabolites) by defining a role fo …
Human constitutive androstane receptor agonist DL5016: A novel sensitizer for cyclophosphamide-based chemotherapies.
Liang D, Li L, Lynch C, Mackowiak B, Hedrich WD, Ai Y, Yin Y, Heyward S, Xia M, Wang H, Xue F. Liang D, et al. Eur J Med Chem. 2019 Oct 1;179:84-99. doi: 10.1016/j.ejmech.2019.06.031. Epub 2019 Jun 15. Eur J Med Chem. 2019. PMID: 31247375 Free PMC article.
As a prodrug, CPA is activated by cytochrome P450 2B6 (CYP2B6), which is transcriptionally regulated by the human constitutive androstane receptor (hCAR). ...
As a prodrug, CPA is activated by cytochrome P450 2B6 (CYP2B6), which is transcriptionally regulated by the human constitutive and
Constitutive androstane receptor 1 is constitutively bound to chromatin and 'primed' for transactivation in hepatocytes.
McMahon M, Ding S, Jimenez LA, Terranova R, Gerard MA, Vitobello A, Moggs J, Henderson CJ, Wolf CR. McMahon M, et al. Mol Pharmacol. 2019 Jan;95(1):97-105. doi: 10.1124/mol.118.113555. Epub 2018 Oct 25. Mol Pharmacol. 2019. PMID: 30361333 Free PMC article.
The constitutive androstane receptor (CAR) is a xenobiotic sensor expressed in hepatocytes that activates genes involved in drug metabolism, lipid homeostasis, and cell proliferation. ...Also, using the inhibitor erlotinib, we could not confirm a role for the …
The constitutive androstane receptor (CAR) is a xenobiotic sensor expressed in hepatocytes that activates genes involve …
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