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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1909 2
1910 1
1913 1
1914 1
1916 2
1918 2
1920 1
1923 1
1926 1
1927 2
1928 1
1930 1
1937 1
1940 3
1944 1
1945 4
1946 5
1947 9
1948 18
1949 6
1950 19
1951 18
1952 21
1953 36
1954 37
1955 47
1956 51
1957 65
1958 96
1959 94
1960 116
1961 152
1962 179
1963 250
1964 330
1965 286
1966 338
1967 378
1968 407
1969 386
1970 404
1971 480
1972 529
1973 583
1974 649
1975 713
1976 701
1977 791
1978 800
1979 904
1980 827
1981 855
1982 945
1983 959
1984 1051
1985 1222
1986 1322
1987 1470
1988 1498
1989 1748
1990 1926
1991 1986
1992 2113
1993 2212
1994 2545
1995 2655
1996 2579
1997 2639
1998 2613
1999 2656
2000 3027
2001 2945
2002 3018
2003 3262
2004 3360
2005 3579
2006 3588
2007 3760
2008 3769
2009 3935
2010 4031
2011 4082
2012 4437
2013 4538
2014 4643
2015 4762
2016 4520
2017 4594
2018 4599
2019 4316
2020 1172
2021 2
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116,901 results
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Methods of Endotoxin Detection.
Su W, Ding X. Su W, et al. J Lab Autom. 2015 Aug;20(4):354-64. doi: 10.1177/2211068215572136. Epub 2015 Feb 26. J Lab Autom. 2015. PMID: 25720597 Review.
The rabbit pyrogen test is the first standard technique for endotoxin detection and, nowadays, has been replaced by the Limulus Amoebocyte Lysate test, which is the most popular detection technique for endotoxin. With in-depth understanding of endotoxin, bios …
The rabbit pyrogen test is the first standard technique for endotoxin detection and, nowadays, has been replaced by the Limulus Amoeb …
The endotoxin hypothesis of neurodegeneration.
Brown GC. Brown GC. J Neuroinflammation. 2019 Sep 13;16(1):180. doi: 10.1186/s12974-019-1564-7. J Neuroinflammation. 2019. PMID: 31519175 Free PMC article. Review.
Endotoxin binds directly to APOE, and the APOE4 variant both sensitises to endotoxin and predisposes to Alzheimer's disease. ...The endotoxin hypothesis is unproven, but if correct, then neurodegeneration may be reduced by decreasing endotoxin levels o
Endotoxin binds directly to APOE, and the APOE4 variant both sensitises to endotoxin and predisposes to Alzheimer's disease. .
Current trends in endotoxin detection and analysis of endotoxin-protein interactions.
Dullah EC, Ongkudon CM. Dullah EC, et al. Crit Rev Biotechnol. 2017 Mar;37(2):251-261. doi: 10.3109/07388551.2016.1141393. Epub 2016 Feb 10. Crit Rev Biotechnol. 2017. PMID: 26863480 Review.
The prevention of endotoxins from contaminating biopharmaceutical products is paramount as endotoxin contamination, even in small quantities, can result in fever, inflammation, sepsis, tissue damage and even lead to death. Highly sensitive and accurate detection of …
The prevention of endotoxins from contaminating biopharmaceutical products is paramount as endotoxin contamination, even in sm …
Low Endotoxin Recovery-Masking of Naturally Occurring Endotoxin.
Reich J, Weyer FA, Tamura H, Nagaoka I, Motschmann H. Reich J, et al. Int J Mol Sci. 2019 Feb 15;20(4):838. doi: 10.3390/ijms20040838. Int J Mol Sci. 2019. PMID: 30781342 Free PMC article.
Endotoxins are cell wall components of Gram-negative bacteria. A release of endotoxins into the human blood stream results in an inflammation reaction that can lead to life-threatening conditions like sepsis. ...In the present study, endotoxin hold-time studi
Endotoxins are cell wall components of Gram-negative bacteria. A release of endotoxins into the human blood stream results in
Endotoxin reduction in protein solutions using octyl β-D-1-thioglucopyranoside wash on chromatography media.
Gadre D, Carlson M, Mullan A, Kabundi I, Pedowitz N, Rieder SA, White N, Yu K, O'Connor E. Gadre D, et al. J Chromatogr A. 2018 Nov 9;1575:49-58. doi: 10.1016/j.chroma.2018.09.021. Epub 2018 Sep 18. J Chromatogr A. 2018. PMID: 30262393
Endotoxins are complex molecules and one of the most challenging impurities requiring separation in biopharmaceutical protein purification processes. ...Finally, we show the impact of the OTG endotoxin removal tool on the biopharmaceutical industry. While maintainin
Endotoxins are complex molecules and one of the most challenging impurities requiring separation in biopharmaceutical protein purific
Endotoxin contamination: a key element in the interpretation of nanosafety studies.
Li Y, Boraschi D. Li Y, et al. Nanomedicine (Lond). 2016 Feb;11(3):269-87. doi: 10.2217/nnm.15.196. Epub 2016 Jan 20. Nanomedicine (Lond). 2016. PMID: 26787429 Free article. Review.
In this review, we report the features of nanoparticle contamination by endotoxin, and the different biological effects of endotoxin-contaminated nanoparticles. We will describe different methods for endotoxin detection applied to nanoparticles, and discuss t …
In this review, we report the features of nanoparticle contamination by endotoxin, and the different biological effects of endotox
Endotoxin neutralizing peptides.
Jerala R, Porro M. Jerala R, et al. Curr Top Med Chem. 2004;4(11):1173-84. doi: 10.2174/1568026043388079. Curr Top Med Chem. 2004. PMID: 15279607 Review.
Endogenous host defense peptides, fragments of endotoxin-binding proteins and synthetic anti-endotoxin peptides fold into alpha-helical, beta-hairpin, extended and compact conformations without regular secondary structure. In animal models many of the peptides have …
Endogenous host defense peptides, fragments of endotoxin-binding proteins and synthetic anti-endotoxin peptides fold into alph …
Endotoxin contamination of apolipoprotein A-I: effect on macrophage proliferation--a cautionary tale.
Jin X, Xu Q, Champion K, Kruth HS. Jin X, et al. Atherosclerosis. 2015 May;240(1):121-4. doi: 10.1016/j.atherosclerosis.2015.03.007. Epub 2015 Mar 9. Atherosclerosis. 2015. PMID: 25778625 Free PMC article.
Endotoxin alone very potently inhibited macrophage proliferation (0.1 ng/ml inhibited macrophage proliferation>90%). Measurement of endotoxin levels in the apolipoprotein products, including an analysis of free versus total endotoxin, the latter which incl
Endotoxin alone very potently inhibited macrophage proliferation (0.1 ng/ml inhibited macrophage proliferation>90%). Measurement o
Broad application and optimization of a single wash-step for integrated endotoxin depletion during protein purification.
Koziel D, Michaelis U, Kruse T. Koziel D, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 1;1091:101-107. doi: 10.1016/j.jchromb.2018.05.029. Epub 2018 May 21. J Chromatogr B Analyt Technol Biomed Life Sci. 2018. PMID: 29860213
Endotoxins contaminate proteins that are produced in E. coli. High levels of endotoxins can influence cellular assays and cause severe adverse effects when administered to humans. ...A single iED wash-step with 0.75% (v/v) TX114 added to the feed and wash buffer can
Endotoxins contaminate proteins that are produced in E. coli. High levels of endotoxins can influence cellular assays and caus
Methods of endotoxin removal from biological preparations: a review.
Magalhães PO, Lopes AM, Mazzola PG, Rangel-Yagui C, Penna TC, Pessoa A Jr. Magalhães PO, et al. J Pharm Pharm Sci. 2007;10(3):388-404. J Pharm Pharm Sci. 2007. PMID: 17727802 Free article. Review.
Due to these reactions, it is essential to remove endotoxins from drugs, injectables, and other biological and pharmaceutical products. ...CONCLUSIONS: Efficient and cost-effective removal of endotoxins from pharmaceutical and biotechnology preparations is challengi …
Due to these reactions, it is essential to remove endotoxins from drugs, injectables, and other biological and pharmaceutical product …
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