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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1999 3
2000 9
2001 14
2002 30
2003 52
2004 55
2005 78
2006 72
2007 69
2008 82
2009 96
2010 100
2011 129
2012 141
2013 162
2014 172
2015 184
2016 204
2017 249
2018 269
2019 236
2020 206
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2,260 results
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Page 1
Farnesoid X nuclear receptor agonists for the treatment of nonalcoholic steatohepatitis.
Venetsanaki V, Karabouta Z, Polyzos SA. Venetsanaki V, et al. Eur J Pharmacol. 2019 Nov 15;863:172661. doi: 10.1016/j.ejphar.2019.172661. Epub 2019 Sep 16. Eur J Pharmacol. 2019. PMID: 31536725 Review.
Obeticholic acid, however, is not the only farnesoid X receptor agonist currently investigated for the treatment of NASH. Another farnesoid X receptor agonist, cilofexor, in combination with firsocostat, an acetyl-CoA carboxylase inhibito …
Obeticholic acid, however, is not the only farnesoid X receptor agonist currently investigated for the treatment of NAS …
An Intestinal Microbiota-Farnesoid X Receptor Axis Modulates Metabolic Disease.
Gonzalez FJ, Jiang C, Patterson AD. Gonzalez FJ, et al. Gastroenterology. 2016 Nov;151(5):845-859. doi: 10.1053/j.gastro.2016.08.057. Epub 2016 Sep 14. Gastroenterology. 2016. PMID: 27639801 Free PMC article. Review.
The decreased BSH resulted in increased levels of tauro-β-muricholic acid (MCA), a substrate of BSH and a potent farnesoid X receptor (FXR) antagonist. ...
The decreased BSH resulted in increased levels of tauro-β-muricholic acid (MCA), a substrate of BSH and a potent farnesoid X
Farnesoid-X Receptor (FXR) as a Promising Pharmaceutical Target in Atherosclerosis.
Moris D, Giaginis C, Tsourouflis G, Theocharis S. Moris D, et al. Curr Med Chem. 2017 May 31;24(11):1147-1157. doi: 10.2174/0929867324666170124151940. Curr Med Chem. 2017. PMID: 28120707 Review.
Bile acids (BA) act as activating signals of endogenous ligands such as Farnesoid-X receptor (FXR). Primary data indicate a potential role of FXR in AS. ...In this aspect, we performed an electronic search through Pub- Med/MEDLINE database by using the key te …
Bile acids (BA) act as activating signals of endogenous ligands such as Farnesoid-X receptor (FXR). Primary data indica …
Role of farnesoid X receptor and bile acids in alcoholic liver disease.
Manley S, Ding W. Manley S, et al. Acta Pharm Sin B. 2015 Mar;5(2):158-67. doi: 10.1016/j.apsb.2014.12.011. Epub 2015 Mar 9. Acta Pharm Sin B. 2015. PMID: 26579442 Free PMC article. Review.
Emerging evidence now suggests that farnesoid X receptor (FXR) and bile acids also play important roles in ALD. In this review, we discuss the effects of alcohol consumption on FXR, bile acids and gut microbiome as well as their impacts on ALD. Moreover, we s …
Emerging evidence now suggests that farnesoid X receptor (FXR) and bile acids also play important roles in ALD. In this …
Progress and challenges of selective Farnesoid X Receptor modulation.
Massafra V, Pellicciari R, Gioiello A, van Mil SWC. Massafra V, et al. Pharmacol Ther. 2018 Nov;191:162-177. doi: 10.1016/j.pharmthera.2018.06.009. Epub 2018 Jun 20. Pharmacol Ther. 2018. PMID: 29933033 Free article. Review.
In the last two decades, bile acids have been recognized as signaling molecules regulating energy metabolism pathways via, amongst others, the farnesoid X receptor (FXR). ...Therefore, research efforts are increasingly focused on the development of selective …
In the last two decades, bile acids have been recognized as signaling molecules regulating energy metabolism pathways via, amongst others, t …
Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease.
Gonzalez FJ, Jiang C, Xie C, Patterson AD. Gonzalez FJ, et al. Dig Dis. 2017;35(3):178-184. doi: 10.1159/000450908. Epub 2017 Mar 1. Dig Dis. 2017. PMID: 28249275 Free PMC article. Review.
Farnesoid X receptor (FXR) regulates the synthesis, transport and enterohepatic circulation of bile acids (BA) by modulating the expression of related genes in the liver and small intestine. ...
Farnesoid X receptor (FXR) regulates the synthesis, transport and enterohepatic circulation of bile acids (BA) by modul
Effects of farnesoid-X-receptor SUMOylation mutation on myocardial ischemia/reperfusion injury in mice.
Gao Y, Zhao Y, Yuan A, Xu L, Huang X, Su Y, Gao L, Ji Q, Pu J, He B. Gao Y, et al. Exp Cell Res. 2018 Oct 15;371(2):301-310. doi: 10.1016/j.yexcr.2018.07.004. Epub 2018 Aug 8. Exp Cell Res. 2018. PMID: 30098335
We previously demonstrated that a nuclear receptor, Farnesoid X receptor (FXR), plays a crucial role in mediating myocardial apoptosis. ...
We previously demonstrated that a nuclear receptor, Farnesoid X receptor (FXR), plays a crucial role in mediatin …
Role of farnesoid X receptor in hepatic steatosis in nonalcoholic fatty liver disease.
Xi Y, Li H. Xi Y, et al. Biomed Pharmacother. 2020 Jan;121:109609. doi: 10.1016/j.biopha.2019.109609. Epub 2019 Nov 12. Biomed Pharmacother. 2020. PMID: 31731192 Free article. Review.
Farnesoid X receptor (FXR) is a major member of the ligand-activated nuclear receptor superfamily. Previous reviews have shown that FXR is a multipurpose receptor that plays an important role in regulating bile acid homeostasis, glucose and lipi
Farnesoid X receptor (FXR) is a major member of the ligand-activated nuclear receptor superfamily. Previous revi
Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration.
Li G, L Guo G. Li G, et al. Acta Pharm Sin B. 2015 Mar;5(2):93-8. doi: 10.1016/j.apsb.2015.01.005. Epub 2015 Feb 20. Acta Pharm Sin B. 2015. PMID: 26579433 Free PMC article. Review.
Bile acids (BAs) are ligands of farnesoid X receptor (FXR), a nuclear receptor of ligand-activated transcription factor. FXR has been shown to be highly involved in liver regeneration. ...
Bile acids (BAs) are ligands of farnesoid X receptor (FXR), a nuclear receptor of ligand-activated transcription …
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