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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1943 3
1944 6
1945 13
1946 151
1947 188
1948 199
1949 160
1950 249
1951 275
1952 230
1953 188
1954 138
1955 143
1956 127
1957 146
1958 144
1959 105
1960 133
1961 153
1962 200
1963 295
1964 416
1965 305
1966 303
1967 328
1968 385
1969 481
1970 565
1971 659
1972 631
1973 590
1974 513
1975 501
1976 453
1977 495
1978 446
1979 431
1980 451
1981 445
1982 472
1983 461
1984 447
1985 478
1986 472
1987 459
1988 480
1989 561
1990 537
1991 575
1992 652
1993 783
1994 703
1995 815
1996 825
1997 950
1998 981
1999 1108
2000 1167
2001 1260
2002 1392
2003 1538
2004 1646
2005 1777
2006 1733
2007 1938
2008 1955
2009 1976
2010 2129
2011 2289
2012 2439
2013 2448
2014 2447
2015 2508
2016 2571
2017 2513
2018 2552
2019 2705
2020 1924
2021 3
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61,836 results
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Folate, folic acid and 5-methyltetrahydrofolate are not the same thing.
Scaglione F, Panzavolta G. Scaglione F, et al. Xenobiotica. 2014 May;44(5):480-8. doi: 10.3109/00498254.2013.845705. Epub 2014 Feb 4. Xenobiotica. 2014. PMID: 24494987 Review.
Most countries have established recommended intakes of folate through folic acid supplements or fortified foods. External supplementation of folate may occur as folic acid, folinic acid or 5-methyltetrahydrofolate (5-MTHF). 3. ...U …
Most countries have established recommended intakes of folate through folic acid supplements or fortified foods. Extern …
Folic acid and primary prevention of neural tube defects: A review.
van Gool JD, Hirche H, Lax H, De Schaepdrijver L. van Gool JD, et al. Reprod Toxicol. 2018 Sep;80:73-84. doi: 10.1016/j.reprotox.2018.05.004. Epub 2018 May 16. Reprod Toxicol. 2018. PMID: 29777755 Review.
With 4 mg folic acid daily, it may take 20 weeks to reach red-blood-cell folate levels between 1050 and 1340 nmol/L, optimal for reduction of the neural tube defect risk. ...The risk of folate intake >1 mg/day does not outweigh the benefits of fo
With 4 mg folic acid daily, it may take 20 weeks to reach red-blood-cell folate levels between 1050 and 1340 nmol/L, op …
Recent Developments in Folate Nutrition.
Naderi N, House JD. Naderi N, et al. Adv Food Nutr Res. 2018;83:195-213. doi: 10.1016/bs.afnr.2017.12.006. Epub 2018 Feb 2. Adv Food Nutr Res. 2018. PMID: 29477222 Review.
Due to the linkage of impaired folate status with an increased prevalence of neural tube defects (NTDs) in babies, several jurisdictions required the fortification of the food supply with folic acid, a synthetic and stable form of folate. ...However, c …
Due to the linkage of impaired folate status with an increased prevalence of neural tube defects (NTDs) in babies, several jurisdicti …
Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics.
Pietrzik K, Bailey L, Shane B. Pietrzik K, et al. Clin Pharmacokinet. 2010 Aug;49(8):535-48. doi: 10.2165/11532990-000000000-00000. Clin Pharmacokinet. 2010. PMID: 20608755 Review.
Thus increased folate intake is now recommended before and during the early stages of pregnancy, through folic acid supplements or fortified foods. ...Bioavailability studies have provided strong evidence that L-5-methyl-THF is at least as effective as fol
Thus increased folate intake is now recommended before and during the early stages of pregnancy, through folic acid sup …
Folate in depression: efficacy, safety, differences in formulations, and clinical issues.
Fava M, Mischoulon D. Fava M, et al. J Clin Psychiatry. 2009;70 Suppl 5:12-7. doi: 10.4088/JCP.8157su1c.03. J Clin Psychiatry. 2009. PMID: 19909688 Free article. Review.
Three forms of folate are commonly used: folic acid, 5-methyltetrahydrofolate (5-MTHF) (also known as methylfolate and L-methylfolate), and folinic acid. ...Evidence for the efficacy of folate in improving cognitive symptoms is equivocal, but mo …
Three forms of folate are commonly used: folic acid, 5-methyltetrahydrofolate (5-MTHF) (also known as methylfolate and …
Folate.
Chan YM, Bailey R, O'Connor DL. Chan YM, et al. Adv Nutr. 2013 Jan 1;4(1):123-5. doi: 10.3945/an.112.003392. Adv Nutr. 2013. PMID: 23319130 Free PMC article. No abstract available.
Role of folate in nonalcoholic fatty liver disease.
Sid V, Siow YL, O K. Sid V, et al. Can J Physiol Pharmacol. 2017 Oct;95(10):1141-1148. doi: 10.1139/cjpp-2016-0681. Epub 2017 May 1. Can J Physiol Pharmacol. 2017. PMID: 28460180 Review.
Folate is a water-soluble B vitamin that plays an essential role in one-carbon transfer reactions involved in nucleic acid biosynthesis, methylation reactions, and sulfur-containing amino acid metabolism. The liver is the primary organ responsible for storage
Folate is a water-soluble B vitamin that plays an essential role in one-carbon transfer reactions involved in nucleic acid bio
l-5-Methyltetrahydrofolate Supplementation Increases Blood Folate Concentrations to a Greater Extent than Folic Acid Supplementation in Malaysian Women.
Henderson AM, Aleliunas RE, Loh SP, Khor GL, Harvey-Leeson S, Glier MB, Kitts DD, Green TJ, Devlin AM. Henderson AM, et al. J Nutr. 2018 Jun 1;148(6):885-890. doi: 10.1093/jn/nxy057. J Nutr. 2018. PMID: 29878267 Clinical Trial.
BACKGROUND: Folic acid fortification of grains is mandated in many countries to prevent neural tube defects. Concerns regarding excessive intakes of folic acid have been raised. ...The l-5-MTHF group had higher RBC folate (1951 ± 496 nmol/L; P = …
BACKGROUND: Folic acid fortification of grains is mandated in many countries to prevent neural tube defects. Concerns regardin …
The Bioavailability of Various Oral Forms of Folate Supplementation in Healthy Populations and Animal Models: A Systematic Review.
Bayes J, Agrawal N, Schloss J. Bayes J, et al. J Altern Complement Med. 2019 Feb;25(2):169-180. doi: 10.1089/acm.2018.0086. Epub 2018 Jul 16. J Altern Complement Med. 2019. PMID: 30010385
The aim of this review was to assess the bioavailability of various forms of folate supplements in healthy populations and animal models. ...There was variation in supplement forms used with the most commonly tested being folic acid followed by 5-methylenetet …
The aim of this review was to assess the bioavailability of various forms of folate supplements in healthy populations and animal mod …
Medicines associated with folate-homocysteine-methionine pathway disruption.
Vidmar M, Grželj J, Mlinarič-Raščan I, Geršak K, Dolenc MS. Vidmar M, et al. Arch Toxicol. 2019 Feb;93(2):227-251. doi: 10.1007/s00204-018-2364-z. Epub 2018 Nov 29. Arch Toxicol. 2019. PMID: 30499019 Review.
Adequate folate levels are essential in women of childbearing age and in pregnant women, and folate deficiency is associated with several congenital malformations. Low folate levels can be caused by dietary deficiencies, a genetic predisposition or treatment …
Adequate folate levels are essential in women of childbearing age and in pregnant women, and folate deficiency is associated w …
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