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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 17
1947 4
1948 9
1949 7
1950 12
1951 27
1952 26
1953 23
1954 16
1955 31
1956 32
1957 36
1958 40
1959 49
1960 69
1961 56
1962 54
1963 38
1964 44
1965 49
1966 8
1967 11
1968 29
1969 26
1970 27
1971 48
1972 62
1973 105
1974 85
1975 152
1976 191
1977 137
1978 132
1979 206
1980 204
1981 231
1982 260
1983 293
1984 366
1985 428
1986 435
1987 468
1988 513
1989 776
1990 1051
1991 1233
1992 1609
1993 2413
1994 2638
1995 3443
1996 3880
1997 4524
1998 5216
1999 6122
2000 7422
2001 7953
2002 8925
2003 9907
2004 10659
2005 12146
2006 13024
2007 13801
2008 15254
2009 16050
2010 18188
2011 20049
2012 21813
2013 23745
2014 26047
2015 28327
2016 28783
2017 29659
2018 30344
2019 30453
2020 19023
2021 78
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387,977 results
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Page 1
[Gene therapy - from idea to reality].
Smith CIE, Blomberg P. Smith CIE, et al. Lakartidningen. 2017 Dec 19;114:EWYL. Lakartidningen. 2017. PMID: 29297925 Free article. Review. Swedish.
Gene therapy - from idea to reality Gene therapy was originally proposed 45 years ago, but it is only during the last 5-10 years that significant clinical benefit has been demonstrated. Gene therapy is in most cases in the form of enginee
Gene therapy - from idea to reality Gene therapy was originally proposed 45 years ago, but it is only during the
Gene therapy on the move.
Kaufmann KB, Büning H, Galy A, Schambach A, Grez M. Kaufmann KB, et al. EMBO Mol Med. 2013 Nov;5(11):1642-61. doi: 10.1002/emmm.201202287. Epub 2013 Sep 17. EMBO Mol Med. 2013. PMID: 24106209 Free PMC article. Review.
The first gene therapy clinical trials were initiated more than two decades ago. ...With more than 1900 clinical trials to date, gene therapy has moved from a vision to clinical reality. This review focuses on the application of gene therapy
The first gene therapy clinical trials were initiated more than two decades ago. ...With more than 1900 clinical trials to dat …
History of gene therapy.
Wirth T, Parker N, Ylä-Herttuala S. Wirth T, et al. Gene. 2013 Aug 10;525(2):162-9. doi: 10.1016/j.gene.2013.03.137. Epub 2013 Apr 23. Gene. 2013. PMID: 23618815 Review.
Despite the setbacks gene therapy has faced, success stories have increasingly emerged. ...In this review, we will take a historical view and highlight some of the milestones that had an important impact on the development of gene therapy. We will also …
Despite the setbacks gene therapy has faced, success stories have increasingly emerged. ...In this review, we will take a hist …
Nonintegrating Gene Therapy Vectors.
Athanasopoulos T, Munye MM, Yáñez-Muñoz RJ. Athanasopoulos T, et al. Hematol Oncol Clin North Am. 2017 Oct;31(5):753-770. doi: 10.1016/j.hoc.2017.06.007. Hematol Oncol Clin North Am. 2017. PMID: 28895845 Review.
Gene delivery vectors that do not rely on host cell genome integration offer several advantages for gene transfer, chiefly the avoidance of insertional mutagenesis and position effect variegation. ...This article provides an overview of the main nonintegrating viral
Gene delivery vectors that do not rely on host cell genome integration offer several advantages for gene transfer, chiefly the
Gene therapy.
Brody H. Brody H. Nature. 2018 Dec;564(7735):S5. doi: 10.1038/d41586-018-07639-9. Nature. 2018. PMID: 30542191 No abstract available.
Gene therapy for neurodegenerative diseases.
O'Connor DM, Boulis NM. O'Connor DM, et al. Trends Mol Med. 2015 Aug;21(8):504-12. doi: 10.1016/j.molmed.2015.06.001. Epub 2015 Jun 26. Trends Mol Med. 2015. PMID: 26122838 Review.
Gene therapy is, potentially, a powerful tool for treating neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy, Parkinson's disease (PD) and Alzheimer's disease (AD). ...These improvements may finally make gene t
Gene therapy is, potentially, a powerful tool for treating neurodegenerative diseases such as amyotrophic lateral sclerosis (A
Gene Therapy for Neurodegenerative Diseases.
Sudhakar V, Richardson RM. Sudhakar V, et al. Neurotherapeutics. 2019 Jan;16(1):166-175. doi: 10.1007/s13311-018-00694-0. Neurotherapeutics. 2019. PMID: 30542906 Free PMC article. Review.
Gene therapy has the potential to provide therapeutic benefit to millions of people with neurodegenerative diseases through several means, including direct correction of pathogenic mechanisms, neuroprotection, neurorestoration, and symptom control. ...The gene
Gene therapy has the potential to provide therapeutic benefit to millions of people with neurodegenerative diseases through se
A brief history of gene therapy.
Friedmann T. Friedmann T. Nat Genet. 1992 Oct;2(2):93-8. doi: 10.1038/ng1092-93. Nat Genet. 1992. PMID: 1303270 Review.
The concepts of gene therapy arose initially during the 1960s and early 1970s whilst the development of genetically marked cells lines and the clarification of mechanisms of cell transformation by the papaovaviruses polyoma and SV40 was in progress. ...Efficient ret …
The concepts of gene therapy arose initially during the 1960s and early 1970s whilst the development of genetically marked cel …
Gene Therapy Now?
Pederson T. Pederson T. FASEB J. 2018 Apr;32(4):1731-1732. doi: 10.1096/fj.180401ufm. FASEB J. 2018. PMID: 29592791 No abstract available.
The Pharmacology of Gene Therapy.
Ylä-Herttuala S. Ylä-Herttuala S. Mol Ther. 2017 Aug 2;25(8):1731-1732. doi: 10.1016/j.ymthe.2017.07.007. Epub 2017 Jul 22. Mol Ther. 2017. PMID: 28739283 Free PMC article. No abstract available.
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