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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1969 1
1970 3
1971 5
1972 16
1973 25
1974 32
1975 57
1976 83
1977 97
1978 124
1979 190
1980 183
1981 215
1982 249
1983 270
1984 345
1985 304
1986 338
1987 353
1988 362
1989 418
1990 430
1991 447
1992 407
1993 504
1994 548
1995 556
1996 561
1997 529
1998 563
1999 586
2000 623
2001 590
2002 633
2003 684
2004 788
2005 808
2006 908
2007 921
2008 909
2009 955
2010 950
2011 1019
2012 1104
2013 1156
2014 1055
2015 1036
2016 1005
2017 1027
2018 985
2019 1063
2020 779
2021 4
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25,438 results
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Page 1
Glucocorticoid receptor modulators.
Meijer OC, Koorneef LL, Kroon J. Meijer OC, et al. Ann Endocrinol (Paris). 2018 Jun;79(3):107-111. doi: 10.1016/j.ando.2018.03.004. Epub 2018 May 3. Ann Endocrinol (Paris). 2018. PMID: 29731108 Review.
The glucocorticoid hormone cortisol acts throughout the body to support circadian processes and adaptation to stress. The glucocorticoid receptor is the target of cortisol and of synthetic glucocorticoids, which are used widely in the clinic. ...Selective …
The glucocorticoid hormone cortisol acts throughout the body to support circadian processes and adaptation to stress. The glucocor
The Glucocorticoid Receptor in Cardiovascular Health and Disease.
Liu B, Zhang TN, Knight JK, Goodwin JE. Liu B, et al. Cells. 2019 Oct 9;8(10):1227. doi: 10.3390/cells8101227. Cells. 2019. PMID: 31601045 Free PMC article. Review.
The glucocorticoid receptor is a member of the nuclear receptor family that controls many distinct gene networks, governing various aspects of development, metabolism, inflammation, and the stress response, as well as other key biological processes in the car …
The glucocorticoid receptor is a member of the nuclear receptor family that controls many distinct gene networks, gover …
Glucocorticoid receptor control of transcription: precision and plasticity via allostery.
Weikum ER, Knuesel MT, Ortlund EA, Yamamoto KR. Weikum ER, et al. Nat Rev Mol Cell Biol. 2017 Mar;18(3):159-174. doi: 10.1038/nrm.2016.152. Epub 2017 Jan 5. Nat Rev Mol Cell Biol. 2017. PMID: 28053348 Free PMC article. Review.
The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory factor (TRF) that controls many distinct gene networks, each uniquely determined by particular cellular and physiological contexts. ...
The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory factor (TRF) that controls many dist …
Selective glucocorticoid receptor modulation: New directions with non-steroidal scaffolds.
Sundahl N, Bridelance J, Libert C, De Bosscher K, Beck IM. Sundahl N, et al. Pharmacol Ther. 2015 Aug;152:28-41. doi: 10.1016/j.pharmthera.2015.05.001. Epub 2015 May 6. Pharmacol Ther. 2015. PMID: 25958032 Free article. Review.
These compounds are classified as selective glucocorticoid receptor agonists (SEGRAs) or selective glucocorticoid receptor modulators (SEGRMs). The latter class is able to modulate the activity of a GR agonist and/or may not classically bind the glu
These compounds are classified as selective glucocorticoid receptor agonists (SEGRAs) or selective glucocorticoid re
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse.
McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonté B, Szyf M, Turecki G, Meaney MJ. McGowan PO, et al. Nat Neurosci. 2009 Mar;12(3):342-8. doi: 10.1038/nn.2270. Nat Neurosci. 2009. PMID: 19234457 Free PMC article.
Maternal care influences hypothalamic-pituitary-adrenal (HPA) function in the rat through epigenetic programming of glucocorticoid receptor expression. ...We found decreased levels of glucocorticoid receptor mRNA, as well as mRNA transcripts bearing th …
Maternal care influences hypothalamic-pituitary-adrenal (HPA) function in the rat through epigenetic programming of glucocorticoid
Corticosteroids: Mechanisms of Action in Health and Disease.
Ramamoorthy S, Cidlowski JA. Ramamoorthy S, et al. Rheum Dis Clin North Am. 2016 Feb;42(1):15-31, vii. doi: 10.1016/j.rdc.2015.08.002. Rheum Dis Clin North Am. 2016. PMID: 26611548 Free PMC article. Review.
The actions of glucocorticoids are predominantly mediated through the classic glucocorticoid receptor (GR). GRs are expressed throughout the body, but there is considerable heterogeneity in glucocorticoid sensitivity and biologic responses across tissues. The …
The actions of glucocorticoids are predominantly mediated through the classic glucocorticoid receptor (GR). GRs are expressed …
Glucocorticoid Resistance.
Nicolaides NC, Charmandari E. Nicolaides NC, et al. Exp Suppl. 2019;111:85-102. doi: 10.1007/978-3-030-25905-1_6. Exp Suppl. 2019. PMID: 31588529 Review.
Primary generalized glucocorticoid resistance or Chrousos syndrome is a rare disorder, which affects all tissues expressing the human glucocorticoid receptor. ...We and others have applied standard methods of molecular and structural biology to investigate th …
Primary generalized glucocorticoid resistance or Chrousos syndrome is a rare disorder, which affects all tissues expressing the human …
Xenobiotics and the Glucocorticoid Receptor.
Gulliver LS. Gulliver LS. Toxicol Appl Pharmacol. 2017 Mar 15;319:69-79. doi: 10.1016/j.taap.2017.02.003. Epub 2017 Feb 4. Toxicol Appl Pharmacol. 2017. PMID: 28174120 Review.
Glucocorticoid Receptor (GR) is present in virtually every human cell type. Representing a nuclear receptor superfamily, GR has several different isoforms essentially acting as ligand-dependent transcription factors, regulating glucocorticoid-responsiv
Glucocorticoid Receptor (GR) is present in virtually every human cell type. Representing a nuclear receptor superfamily
Selective Glucocorticoid Receptor modulators.
De Bosscher K. De Bosscher K. J Steroid Biochem Mol Biol. 2010 May 31;120(2-3):96-104. doi: 10.1016/j.jsbmb.2010.02.027. Epub 2010 Mar 4. J Steroid Biochem Mol Biol. 2010. PMID: 20206690 Review.
Thus more knowledge-based fundamental research is needed to ensure the design and development of selective Glucocorticoid Receptor modulators capable of reaching the clinic. Recent advances in the characterization of novel selective Glucocorticoid Receptor
Thus more knowledge-based fundamental research is needed to ensure the design and development of selective Glucocorticoid Receptor
Glucocorticoid receptor physiology.
Heitzer MD, Wolf IM, Sanchez ER, Witchel SF, DeFranco DB. Heitzer MD, et al. Rev Endocr Metab Disord. 2007 Dec;8(4):321-30. doi: 10.1007/s11154-007-9059-8. Rev Endocr Metab Disord. 2007. PMID: 18049904 Review.
Glucocorticoid action in cells is mediated by a specific receptor protein, the glucocorticoid receptor (GR). GR is a member of a superfamily of ligand-inducible transcription factors that control a variety of physiological functions; such as, metabolis
Glucocorticoid action in cells is mediated by a specific receptor protein, the glucocorticoid receptor (GR). GR
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