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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 1
1964 1
1968 2
1970 1
1971 2
1972 1
1973 2
1974 3
1975 3
1976 5
1977 4
1978 8
1979 9
1980 11
1981 12
1982 14
1983 21
1984 10
1985 9
1986 10
1987 16
1988 13
1989 17
1990 14
1991 13
1992 17
1993 15
1994 24
1995 20
1996 15
1997 5
1998 19
1999 22
2000 16
2001 15
2002 12
2003 17
2004 19
2005 16
2006 19
2007 17
2008 11
2009 10
2010 6
2011 17
2012 13
2013 14
2014 16
2015 14
2016 12
2017 18
2018 17
2019 28
2020 19
2021 4
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648 results
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Page 1
Canine Copper-Associated Hepatitis.
Dirksen K, Fieten H. Dirksen K, et al. Vet Clin North Am Small Anim Pract. 2017 May;47(3):631-644. doi: 10.1016/j.cvsm.2016.11.011. Epub 2017 Jan 5. Vet Clin North Am Small Anim Pract. 2017. PMID: 28063745 Review.
The disease is characterized by centrolobular hepatic copper accumulation, leading to hepatitis and eventually cirrhosis. ...In addition, a low-copper/high-zinc diet can help prevent accumulation or reaccumulation of hepatic copper. ...
The disease is characterized by centrolobular hepatic copper accumulation, leading to hepatitis and eventually cirrhosis. ...I …
Canine Idiopathic Chronic Hepatitis.
Bexfield N. Bexfield N. Vet Clin North Am Small Anim Pract. 2017 May;47(3):645-663. doi: 10.1016/j.cvsm.2016.11.012. Epub 2017 Jan 4. Vet Clin North Am Small Anim Pract. 2017. PMID: 28063746 Review.
There are variations in histologic appearance between breeds. Hepatic copper accumulation is an important cause of canine CH. However, where copper accumulation has been ruled out, dogs are said to have idiopathic CH. This article reviews theories regarding t …
There are variations in histologic appearance between breeds. Hepatic copper accumulation is an important cause of canine CH. …
Wilson's Disease: A Review for the General Pediatrician.
Capone K, Azzam RK. Capone K, et al. Pediatr Ann. 2018 Nov 1;47(11):e440-e444. doi: 10.3928/19382359-20181026-01. Pediatr Ann. 2018. PMID: 30423186 Review.
Wilson's disease, also known as hepatolenticular degeneration, is an autosomal recessive genetic disorder due to a mutation of the ATP7B gene resulting in impaired hepatic copper excretion and copper accumulation in various tissues. ...
Wilson's disease, also known as hepatolenticular degeneration, is an autosomal recessive genetic disorder due to a mutation of the ATP7B gen …
Hepatic copper and other trace mineral concentrations in dogs with hepatocellular carcinoma.
Harro CC, Smedley RC, Buchweitz JP, Langlois DK. Harro CC, et al. J Vet Intern Med. 2019 Sep;33(5):2193-2199. doi: 10.1111/jvim.15619. Epub 2019 Sep 7. J Vet Intern Med. 2019. PMID: 31493348 Free PMC article.

RESULTS: Hepatic copper concentrations (non-neoplastic hepatic tissue) were greater in test population dogs (median, IQR; 294.9 mug/g, 233.5-475.9 mug/g) than in control dogs (202.8 mug/g, 135.0-295.3 mug/g; P < .001). ...Within test population dogs, all t

RESULTS: Hepatic copper concentrations (non-neoplastic hepatic tissue) were greater in test population dogs (median, IQ …
Classification and differential diagnosis of Wilson's disease.
Hermann W. Hermann W. Ann Transl Med. 2019 Apr;7(Suppl 2):S63. doi: 10.21037/atm.2019.02.07. Ann Transl Med. 2019. PMID: 31179300 Free PMC article. Review.
Until the unequivocal proof or an autosomal recessive disorder of the hepatic copper transporter ATP7B has been ruled out, differential diagnoses have to be examined. Laboratory-chemical parameters of copper metabolism can both be deviations from the norm not …
Until the unequivocal proof or an autosomal recessive disorder of the hepatic copper transporter ATP7B has been ruled out, dif …
Short communication: Survey of hepatic copper concentrations in Midwest dairy cows.
Strickland JM, Herdt TH, Sledge DG, Buchweitz JP. Strickland JM, et al. J Dairy Sci. 2019 May;102(5):4209-4214. doi: 10.3168/jds.2018-15566. Epub 2019 Mar 1. J Dairy Sci. 2019. PMID: 30827550
It has also been speculated that hepatic copper concentrations have been increasing in recent years. ...Hepatic copper concentrations in our retrospective study did not increase with time. ...
It has also been speculated that hepatic copper concentrations have been increasing in recent years. ...Hepatic copp
Predicting copper toxicosis: relationship between the ATP7A and ATP7B gene mutations and hepatic copper quantification in dogs.
Pindar S, Ramirez C. Pindar S, et al. Hum Genet. 2019 May;138(5):541-546. doi: 10.1007/s00439-019-02010-y. Epub 2019 May 6. Hum Genet. 2019. PMID: 31062085
We evaluated serum ALT levels, hepatic copper concentrations, and hepatic histopathology from ten offspring where both parents had a least one copy of the ATP7B mutation. ...Mean hepatic copper concentration in homozygous normal and heterozygous …
We evaluated serum ALT levels, hepatic copper concentrations, and hepatic histopathology from ten offspring where both …
Biomarkers for diagnosis of Wilson's disease.
Ryan A, Nevitt SJ, Tuohy O, Cook P. Ryan A, et al. Cochrane Database Syst Rev. 2019 Nov 19;2019(11):CD012267. doi: 10.1002/14651858.CD012267.pub2. Cochrane Database Syst Rev. 2019. PMID: 31743430 Free PMC article.
Using the cut-off of 0.1 g/L of the Leipzig criteria seemed to lower the sensitivity overall, 65% to 78.9%, while increasing the specificity to 96.6% to 100%. INDEX TEST: hepatic copper Four studies evaluated various thresholds of hepatic copper (1150 …
Using the cut-off of 0.1 g/L of the Leipzig criteria seemed to lower the sensitivity overall, 65% to 78.9%, while increasing the specificity …
Effects of Super Nutritional Hepatic Copper Accumulation on Hepatocyte Health and Oxidative Stress in Dairy Cows.
Strickland JM, Lyman D, Sordillo LM, Herdt TH, Buchweitz JP. Strickland JM, et al. Vet Med Int. 2019 May 5;2019:3642954. doi: 10.1155/2019/3642954. eCollection 2019. Vet Med Int. 2019. PMID: 31191898 Free PMC article.
Concerns regarding excessive hepatic copper concentrations in dairy cows have increased. The objective of this study was to determine the association of hepatic copper concentrations with evidence of liver disease. ...No association was found between …
Concerns regarding excessive hepatic copper concentrations in dairy cows have increased. The objective of this study was to de …
Hepatic copper concentrations in 546 dogs (1982-2015).
Strickland JM, Buchweitz JP, Smedley RC, Olstad KJ, Schultz RS, Oliver NB, Langlois DK. Strickland JM, et al. J Vet Intern Med. 2018 Nov;32(6):1943-1950. doi: 10.1111/jvim.15308. Epub 2018 Oct 7. J Vet Intern Med. 2018. PMID: 30294943 Free PMC article.
BACKGROUND: Copper associated hepatitis (CAH) has been increasingly recognized in dogs, and speculation exists that hereditary defects in copper metabolism have been exacerbated by increased environmental copper exposure. However, no broad epidemiological inv …
BACKGROUND: Copper associated hepatitis (CAH) has been increasingly recognized in dogs, and speculation exists that hereditary defect …
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