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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1975 2
1976 1
1979 3
1980 1
1981 3
1982 4
1983 3
1984 4
1985 4
1986 2
1987 6
1988 11
1989 18
1990 36
1991 49
1992 55
1993 107
1994 117
1995 104
1996 144
1997 191
1998 209
1999 194
2000 241
2001 231
2002 281
2003 286
2004 298
2005 312
2006 372
2007 346
2008 367
2009 372
2010 418
2011 420
2012 456
2013 490
2014 519
2015 491
2016 484
2017 506
2018 521
2019 488
2020 295
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8,534 results
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Page 1
Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases.
Yeh MM, Bosch DE, Daoud SS. Yeh MM, et al. World J Gastroenterol. 2019 Aug 14;25(30):4074-4091. doi: 10.3748/wjg.v25.i30.4074. World J Gastroenterol. 2019. PMID: 31435165 Free PMC article. Review.
Hepatocyte nuclear factor 4-alpha (HNF4α) is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs (pancreas, stomach, and intestine). ...
Hepatocyte nuclear factor 4-alpha (HNF4α) is a highly conserved member of nuclear receptor superfamily of ligand
Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors.
Cheng Z, He Z, Cai Y, Zhang C, Fu G, Li H, Sun W, Liu C, Cui X, Ning B, Xiang D, Zhou T, Li X, Xie W, Wang H, Ding J. Cheng Z, et al. Cell Res. 2019 Feb;29(2):124-135. doi: 10.1038/s41422-018-0111-x. Epub 2018 Dec 18. Cell Res. 2019. PMID: 30560924 Free PMC article.
Here, we report that the combination of hepatocyte nuclear factor 1A (HNF1A), HNF4A and forkhead box protein A3 (FOXA3) synergistically reprograms hepatocellular carcinoma (HCC) cells to hepatocyte-like cells (reprogrammed hepatocytes, rHeps). ...Mecha …
Here, we report that the combination of hepatocyte nuclear factor 1A (HNF1A), HNF4A and forkhead box protein A3 (FOXA3) …
The molecular functions of hepatocyte nuclear factors - In and beyond the liver.
Lau HH, Ng NHJ, Loo LSW, Jasmen JB, Teo AKK. Lau HH, et al. J Hepatol. 2018 May;68(5):1033-1048. doi: 10.1016/j.jhep.2017.11.026. Epub 2017 Nov 24. J Hepatol. 2018. PMID: 29175243 Review.
The hepatocyte nuclear factors (HNFs) namely HNF1α/β, FOXA1/2/3, HNF4α/γ and ONECUT1/2 are expressed in a variety of tissues and organs, including the liver, pancreas and kidney. ...In this review, we compare and contrast the expression patterns of the HNFs, …
The hepatocyte nuclear factors (HNFs) namely HNF1α/β, FOXA1/2/3, HNF4α/γ and ONECUT1/2 are expressed in a variety of ti …
Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors.
Sekiya S, Suzuki A. Sekiya S, et al. Nature. 2011 Jun 29;475(7356):390-3. doi: 10.1038/nature10263. Nature. 2011. PMID: 21716291
These unexpected findings suggest that factors critical to hepatocyte differentiation exist and become activated to induce hepatocyte-specific properties in different cell types. ...The induced hepatocyte-like (iHep) cells have multiple hepatocyte
These unexpected findings suggest that factors critical to hepatocyte differentiation exist and become activated to induce …
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3).
Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M, Southam L, Cox RD, Lathrop GM, Boriraj VV, Chen X, Cox NJ, Oda Y, Yano H, Le Beau MM, Yamada S, Nishigori H, Takeda J, Fajans SS, Hattersley AT, Iwasaki N, Hansen T, Pedersen O, Polonsky KS, Bell GI, et al. Yamagata K, et al. Nature. 1996 Dec 5;384(6608):455-8. doi: 10.1038/384455a0. Nature. 1996. PMID: 8945470 Free article.
Genetic factors are important in the aetiology of NIDDM, and linkage studies are starting to localize some of the genes that influence the development of this disorder. ...Here we show that subjects with the MODY3-form of NIDDM have mutations in the gene encoding hepato
Genetic factors are important in the aetiology of NIDDM, and linkage studies are starting to localize some of the genes that influenc …
Elucidating the Mutational Landscape in Hepatocyte Nuclear Factor 1β (HNF1B) by Computational Approach.
Sneha P, Doss CG. Sneha P, et al. Adv Protein Chem Struct Biol. 2017;107:283-306. doi: 10.1016/bs.apcsb.2016.11.005. Epub 2017 Jan 3. Adv Protein Chem Struct Biol. 2017. PMID: 28215227 Review.
Transcription factors are the major gene-regulatory proteins that recognize specific nucleotide sequences and bind to them. Missense mutations in transcription factors play a significant role in misregulation of gene expression contributing to various diseases and d …
Transcription factors are the major gene-regulatory proteins that recognize specific nucleotide sequences and bind to them. Missense …
FOXA2 controls the cis-regulatory networks of pancreatic cancer cells in a differentiation grade-specific manner.
Milan M, Balestrieri C, Alfarano G, Polletti S, Prosperini E, Spaggiari P, Zerbi A, Diaferia GR, Natoli G. Milan M, et al. EMBO J. 2019 Oct 15;38(20):e102161. doi: 10.15252/embj.2019102161. Epub 2019 Sep 17. EMBO J. 2019. PMID: 31531882 Free PMC article.
Differentiation of normal and tumor cells is controlled by regulatory networks enforced by lineage-determining transcription factors (TFs). ...
Differentiation of normal and tumor cells is controlled by regulatory networks enforced by lineage-determining transcription factors
Pathophysiological Role of Hepatocyte Nuclear Factor 6 in Negative Regulation of Hepatic Apoptosis: A Novel Hypothesis.
Wang K. Wang K. Curr Mol Med. 2015;15(5):412-7. doi: 10.2174/1566524015666150630124142. Curr Mol Med. 2015. PMID: 26166417 Review.
Liver injury induces a downregulation of hepatocyte nuclear factor 6 (HNF6) that is negatively correlated with the degree of apoptosis. ...
Liver injury induces a downregulation of hepatocyte nuclear factor 6 (HNF6) that is negatively correlated with the degr …
[Hepatocyte nuclear factor 4 (HNF4) in epithelial development and carcinogenesis].
Lazarevich NL, Al'pern DV. Lazarevich NL, et al. Mol Biol (Mosk). 2008 Sep-Oct;42(5):786-97. Mol Biol (Mosk). 2008. PMID: 18988528 Review. Russian.
Hepatocyte nuclear factors play the key role in the establishing and maintenance of hepatocyte differentiation. They not only control the expression of functional hepatic genes but are also involved in the regulation of proliferation, morphogenesis and
Hepatocyte nuclear factors play the key role in the establishing and maintenance of hepatocyte differentiation.
Hepatocyte nuclear factor 1 coordinates multiple processes in a model of intestinal epithelial cell function.
Yang R, Kerschner JL, Harris A. Yang R, et al. Biochim Biophys Acta. 2016 Apr;1859(4):591-8. doi: 10.1016/j.bbagrm.2016.02.005. Epub 2016 Feb 6. Biochim Biophys Acta. 2016. PMID: 26855178 Free PMC article.
Mutations in hepatocyte nuclear factor 1 transcription factors (HNF1α/β) are associated with diabetes. These factors are well studied in the liver, pancreas and kidney, where they direct tissue-specific gene regulation. ...Approximately 50% of H …
Mutations in hepatocyte nuclear factor 1 transcription factors (HNF1α/β) are associated with diabetes. These …
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