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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 2
1980 1
1989 1
1991 2
1994 3
1995 1
1996 2
1998 2
2000 2
2001 1
2002 5
2003 4
2004 1
2005 7
2006 9
2007 21
2008 11
2009 7
2010 14
2011 12
2012 20
2013 20
2014 27
2015 28
2016 30
2017 31
2018 23
2019 43
2020 28
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319 results
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Page 1
Herb-Drug Interactions and Hepatotoxicity.
Parvez MK, Rishi V. Parvez MK, et al. Curr Drug Metab. 2019;20(4):275-282. doi: 10.2174/1389200220666190325141422. Curr Drug Metab. 2019. PMID: 30914020 Review.
Notably, there exists a potential risk of herb-drug interactions leading to some adverse side effects, including hepatotoxicity. ...This review article discusses the herb-drug interactions related hepatotoxicity and underlying mechanisms, including dru …
Notably, there exists a potential risk of herb-drug interactions leading to some adverse side effects, including hepatotoxicity
Hepatoprotection and hepatotoxicity of Heshouwu, a Chinese medicinal herb: Context of the paradoxical effect.
Li H, Wang X, Liu Y, Pan D, Wang Y, Yang N, Xiang L, Cai X, Feng Y. Li H, et al. Food Chem Toxicol. 2017 Oct;108(Pt B):407-418. doi: 10.1016/j.fct.2016.07.035. Epub 2016 Jul 30. Food Chem Toxicol. 2017. PMID: 27484243 Review.
Hepatoprotection and hepatotoxicity of Shengshouwu and Zhiheshouwu in vitro and in vivo, and their clinical settings and adverse drug reactions (ADR) were summarized, analyzed and critically reviewed. ...In conclusion, Heshouwu exhibited both hepatoprotection and hepato
Hepatoprotection and hepatotoxicity of Shengshouwu and Zhiheshouwu in vitro and in vivo, and their clinical settings and adverse drug …
Drug, Herb, and Dietary Supplement Hepatotoxicity.
Teschke R, Andrade RJ. Teschke R, et al. Int J Mol Sci. 2016 Sep 6;17(9):1488. doi: 10.3390/ijms17091488. Int J Mol Sci. 2016. PMID: 27608014 Free PMC article.
Hepatotoxicity of monoterpenes and sesquiterpenes.
Zárybnický T, Boušová I, Ambrož M, Skálová L. Zárybnický T, et al. Arch Toxicol. 2018 Jan;92(1):1-13. doi: 10.1007/s00204-017-2062-2. Epub 2017 Sep 13. Arch Toxicol. 2018. PMID: 28905185 Review.
There is a high probability that many other terpenes, without sufficiently known metabolism and effects in human liver, could also exert hepatotoxicity. Especially terpenes, that are important components of essential oils with proved hepatotoxicity, should deserve m …
There is a high probability that many other terpenes, without sufficiently known metabolism and effects in human liver, could also exert …
From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy.
Efferth T. Efferth T. Semin Cancer Biol. 2017 Oct;46:65-83. doi: 10.1016/j.semcancer.2017.02.009. Epub 2017 Feb 28. Semin Cancer Biol. 2017. PMID: 28254675 Review.
Because of unexpected cases of hepatotoxicity, combinations of ARS-type drugs with complementary and alternative medicines are not recommended, until controlled clinical trials will prove the safety of non-approved combination treatments....
Because of unexpected cases of hepatotoxicity, combinations of ARS-type drugs with complementary and alternative medicines are not re …
Herbal Hepatotoxicity: Clinical Characteristics and Listing Compilation.
Frenzel C, Teschke R. Frenzel C, et al. Int J Mol Sci. 2016 Apr 27;17(5):588. doi: 10.3390/ijms17050588. Int J Mol Sci. 2016. PMID: 27128912 Free PMC article. Review.
Herb induced liver injury (HILI) and drug induced liver injury (DILI) share the common characteristic of chemical compounds as their causative agents, which were either produced by the plant or synthetic processes. ...During this process, hepatotoxic metabolites may
Herb induced liver injury (HILI) and drug induced liver injury (DILI) share the common characteristic of chemical compounds as their
Licorice root extract and magnesium isoglycyrrhizinate protect against triptolide-induced hepatotoxicity via up-regulation of the Nrf2 pathway.
Tan QY, Hu Q, Zhu SN, Jia LL, Xiao J, Su HZ, Huang SY, Zhang J, Jin J. Tan QY, et al. Drug Deliv. 2018 Nov;25(1):1213-1223. doi: 10.1080/10717544.2018.1472676. Drug Deliv. 2018. PMID: 29791258 Free PMC article.
Triptolide, the predominant biologically active component of the Chinese herb Tripterygium wilfordii Hook f., possesses numerous pharmacological activities, including anti-inflammatory, anti-fertility, anti-neoplastic, and immunosuppressive effects. ...Hepatotoxicity
Triptolide, the predominant biologically active component of the Chinese herb Tripterygium wilfordii Hook f., possesses numerous phar …
RUCAM in Drug and Herb Induced Liver Injury: The Update.
Danan G, Teschke R. Danan G, et al. Int J Mol Sci. 2015 Dec 24;17(1):14. doi: 10.3390/ijms17010014. Int J Mol Sci. 2015. PMID: 26712744 Free PMC article. Review.
RUCAM (Roussel Uclaf Causality Assessment Method) or its previous synonym CIOMS (Council for International Organizations of Medical Sciences) is a well established tool in common use to quantitatively assess causality in cases of suspected drug induced liver injury (DILI) and …
RUCAM (Roussel Uclaf Causality Assessment Method) or its previous synonym CIOMS (Council for International Organizations of Medical Sciences …
Paradoxical Effects of Emodin on ANIT-Induced Intrahepatic Cholestasis and Herb-Induced Hepatotoxicity in Mice.
Wang X, Han L, Bi Y, Li C, Gao X, Fan G, Zhang Y. Wang X, et al. Toxicol Sci. 2019 Mar 1;168(1):264-278. doi: 10.1093/toxsci/kfy295. Toxicol Sci. 2019. PMID: 30517764
Together, the present study identifies a potential pro-cholestatic role of emodin in the hepatotoxicity of herbs....
Together, the present study identifies a potential pro-cholestatic role of emodin in the hepatotoxicity of herbs....
St. John's Wort.
[No authors listed] [No authors listed] 2020 Mar 28. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. 2012–. PMID: 31644187 Free Books & Documents. Review.
John’s wort has not been implicated convincingly in cases of clinically apparent, acute liver injury, although it may increase the hepatotoxicity of other agents by herb-drug interactions that alter drug metabolism....
John’s wort has not been implicated convincingly in cases of clinically apparent, acute liver injury, although it may increase the hepato
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